A new method for screening diagnosis of insulin resistance.

A simple method for the diagnosis of insulin resistance, easily realized in clinical practice, is developed in order to detect patients at a high risk of diseases associated with this condition. The metabolic index is estimated as the proportion of triglycerides and glucose values to quadratic HDL cholesterol value (in mmol/liter). The specific feature of this method for detection of insulin resistance in comparison with the known indirect methods is the use of routine biochemical values, evaluated in venous serum, for estimations. Estimation of this metabolic index is an economic and effective indirect method for evaluating the homeostasis system without additional evaluation of blood hormones.

[New metabolic index in the diagnosis of insulin resistance in patients with nonalcoholic fatty liver disease].

UNLABELLED: Early diagnosis of insulin resistance (IR) in patients with non-alcoholic fatty liver disease (NAFLD) is relevant in connection with the possibility of timely correction and the primary prevention of cardiovascular disease. OBJECTIVE: To evaluate the diagnostic significance of the new metabolic index (MI) in the early diagnosis of IR in patients with NAFLD. MATERIALS AND METHODS: In 494 patients with ultrasonographic evidence of NAFLD have been studied lipid and carbohydrate metabolism. Indirect methods of assessment of IR were analyzed and we proposed a new MI. RESULTS AND DISCUSSION: NAFLD is accompanied by a progression of metabolic disorders and atherogenic dyslipidemia, disorders of carbohydrate metabolism, changes in the functional state of the liver. In the early stages of IR for the initial isolate changes of carbohydrates and lipid metabolism MI index is more sensitive to the existing violations, and with the progression of changes in laboratory parameters observed its gradual increase. CONCLUSIONS: MI can be recommended in clinical practice for screening IR in NAFLD patients for further in-depth examination.

[The integrated approach to diagnostics of metabolic syndrome in clinical practice].

Basic criteria of diagnostics and definitions of metabolic syndrome recommended by various international associations and expert groups are discussed. Permanent changes of criteria and usage of various approaches to diagnostics influence prevalence of metabolic syndrome among populations and estimation of its association with unfavorable outcomes. Some definitions of metabolic syndrome are more sensitive in detection of risk groups for cardiovascular diseases, and others in - detection of persons with high risk of type 2 diabetes mellitus. New integrated definition of metabolic syndrome which unites pathophysiological and clinical epidemiological approaches for assessment of metabolic disorders and detection of high risk groups of patients applicable for use in everyday clinical practice is presented.

[The role of insulin resistance in diagnosis of metabolic syndrome]. / Rol' insulinorezistentnosti v diagnostike metabolicheskogo sindroma.

Early diagnosis of metabolic syndrome is based on detection of insulin resistance, hyperinsulinemia, and clinical presentations of this syndrome. Differences in approaches to diagnosis of metabolic syndrome and its multi component nature hamper comparison of results of different studies and elaboration of generalized guidelines for selection of high risk groups and prevention of cardiovascular diseases and type 2 diabetes. Until present there are no common criteria of the syndrome and this makes difficult standardization of methodology of its investigation. Several organizations (WHO, National Cholesterol Education Program, European Group for the Study of Insulin Resistance) issued documents in which diagnostic approaches to detection of metabolic syndrome and its separate components have been formulated. These approaches as well as comparative analysis of direct and calculated methods of assessment of insulin resistance are presented in this review.

[Effect of different diets on quality of life in patients with metabolic syndrome]. / Vliianie razlichnykh diet na kachestvo zhizni patsientov s metabolicheskim sindromom.

The purpose of the research was to study influence of diets with a various ratio of carbohydrates and fatty components on modification of metabolic risk factors due to decrease of weight and abdominal adiposity, and also on quality of life of the patient. 49 males were included in the study the age 30-65 years with metabolic syndrome X. All patients had increased body mass or obesity. Hypertension of I and II stages was observed in 49.0% of cases. The estimation of results was carried out in three months after assignment of one of investigated diets. Effective reduction of body mass parameters was achieved at use of all diets within three months. Nutritional counseling was based on dietary preferences and habits of the patient to improve quality of life at observance of a diet. Common negative feature of investigated diets was occurrence of feeling of hunger that caused infringement of accuracy of observance of recommendations.

[Influence of various diets on lipid exchange in patients with obesity and metabolic syndrome]. / Vliianie razlichnykh lechebnykh diet na obmen lipidov u patsientov s ozhireniem i metabolicheskim sindromom.

The investigation of influence the diets with different rations carbohydrate and lipid components on the status of lipid spectrum of patients, suffering of metabolic syndrome, these were be used during 4 mounts, was the aim of present researches. The 84 male in the age of 30-65 years were examination Effective decrease body mass, atherogenic parameters of lipid metabolism (hypertrigleciridemia, LDL) and also the levels of arterial hypertension were founded in patients? Using low carbohydrate and low fatty diets.