Detalhe da pesquisa
1.
GGPS1 Mutations Cause Muscular Dystrophy/Hearing Loss/Ovarian Insufficiency Syndrome.
Ann Neurol
; 88(2): 332-347, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32403198
2.
Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming.
Nat Chem Biol
; 15(5): 519-528, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30962627
3.
Design, Synthesis and Characterization of Covalent KDM5 Inhibitors.
Angew Chem Int Ed Engl
; 58(2): 515-519, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30431220
4.
Fluorescent Bisphosphonate and Carboxyphosphonate Probes: A Versatile Imaging Toolkit for Applications in Bone Biology and Biomedicine.
Bioconjug Chem
; 27(2): 329-40, 2016 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26646666
5.
GGPS1 Mutation and Atypical Femoral Fractures with Bisphosphonates.
N Engl J Med
; 376(18): 1794-1795, 2017 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28467865
6.
HSD3B1 is an oxysterol 3ß-hydroxysteroid dehydrogenase in human placenta.
Open Biol
; 13(5): 220313, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37132223
7.
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2.
ACS Med Chem Lett
; 14(4): 432-441, 2023 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-37077385
8.
Structural and non-coding variants increase the diagnostic yield of clinical whole genome sequencing for rare diseases.
Genome Med
; 15(1): 94, 2023 11 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37946251
9.
Molecular characterization of a novel geranylgeranyl pyrophosphate synthase from Plasmodium parasites.
J Biol Chem
; 286(5): 3315-22, 2011 Feb 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21084289
10.
Bisphosphonates: The role of chemistry in understanding their biological actions and structure-activity relationships, and new directions for their therapeutic use.
Bone
; 156: 116289, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34896359
11.
BRD9-containing non-canonical BAF complex maintains somatic cell transcriptome and acts as a barrier to human reprogramming.
Stem Cell Reports
; 17(12): 2629-2642, 2022 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36332631
12.
Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells.
Biochem Biophys Res Commun
; 407(4): 663-7, 2011 Apr 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21420384
13.
The Prolyl-tRNA Synthetase Inhibitor Halofuginone Inhibits SARS-CoV-2 Infection.
bioRxiv
; 2021 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-33791697
14.
AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.
J Steroid Biochem Mol Biol
; 189: 218-227, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-30769091
15.
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
J Med Chem
; 62(20): 9008-9025, 2019 10 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31550156
16.
Modulation of osteoclastogenesis by fatty acids.
Endocrinology
; 149(11): 5688-95, 2008 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-18617622
17.
Structure-activity relationships among the nitrogen containing bisphosphonates in clinical use and other analogues: time-dependent inhibition of human farnesyl pyrophosphate synthase.
J Med Chem
; 51(7): 2187-95, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18327899
18.
Functional Characterization of a GGPPS Variant Identified in Atypical Femoral Fracture Patients and Delineation of the Role of GGPPS in Bone-Relevant Cell Types.
J Bone Miner Res
; 33(12): 2091-2098, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30184270
19.
Discovery of Orally Bioavailable, Quinoline-Based Aldehyde Dehydrogenase 1A1 (ALDH1A1) Inhibitors with Potent Cellular Activity.
J Med Chem
; 61(11): 4883-4903, 2018 06 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29767973
20.
Synthesis and biological evaluation of alpha-halogenated bisphosphonate and phosphonocarboxylate analogues of risedronate.
J Med Chem
; 50(24): 5967-75, 2007 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-17975902