Detalhe da pesquisa
1.
CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors.
Proc Natl Acad Sci U S A
; 120(6): e2212072120, 2023 02 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-36724254
2.
ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer.
BMC Cancer
; 22(1): 1107, 2022 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36309653
3.
Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models.
Br J Cancer
; 123(9): 1424-1436, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32741974
4.
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Nat Chem Biol
; 12(10): 815-21, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27526030
5.
Identification of Novel, Selective Ataxia-Telangiectasia Mutated Kinase Inhibitors with the Ability to Penetrate the Blood-Brain Barrier: The Discovery of AZD1390.
J Med Chem
; 67(4): 3090-3111, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38306388
6.
ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis.
Clin Cancer Res
; 29(21): 4492-4503, 2023 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37585496
7.
Metnase promotes restart and repair of stalled and collapsed replication forks.
Nucleic Acids Res
; 38(17): 5681-91, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457750
8.
ALT neuroblastoma chemoresistance due to telomere dysfunction-induced ATM activation is reversible with ATM inhibitor AZD0156.
Sci Transl Med
; 13(607)2021 08 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34408079
9.
UV radiation induces delayed hyperrecombination associated with hypermutation in human cells.
Mol Cell Biol
; 26(16): 6047-55, 2006 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16880516
10.
ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks.
Nat Commun
; 10(1): 87, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30622252
11.
The Identification of Potent, Selective, and Orally Available Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase: The Discovery of AZD0156 (8-{6-[3-(Dimethylamino)propoxy]pyridin-3-yl}-3-methyl-1-(tetrahydro-2 H-pyran-4-yl)-1,3-dihydro-2 H-imidazo[4,5- c]quinolin-2-one).
J Med Chem
; 61(9): 3823-3841, 2018 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29683659
12.
The brain-penetrant clinical ATM inhibitor AZD1390 radiosensitizes and improves survival of preclinical brain tumor models.
Sci Adv
; 4(6): eaat1719, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29938225
13.
Orally Bioavailable and Blood-Brain Barrier-Penetrating ATM Inhibitor (AZ32) Radiosensitizes Intracranial Gliomas in Mice.
Mol Cancer Ther
; 17(8): 1637-1647, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29769307
14.
Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.
PLoS One
; 12(6): e0179278, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-28628639
15.
Interactions of the DNA mismatch repair proteins MLH1 and MSH2 with c-MYC and MAX.
Oncogene
; 22(6): 819-25, 2003 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-12584560
16.
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease.
Free Radic Biol Med
; 88(Pt B): 108-146, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26122708
17.
Development of a high-throughput fluorescence polarization DNA cleavage assay for the identification of FEN1 inhibitors.
J Biomol Screen
; 18(5): 567-75, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23427045
18.
Telomerase-independent paths to immortality in predictable cancer subtypes.
J Cancer
; 3: 67-82, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22315652
19.
Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives.
PLoS One
; 7(12): e50889, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-23251397
20.
p53 methylation--the Arg-ument is clear.
Cell Cycle
; 8(6): 801-2, 2009 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19221494