A Systematic Review of Genetics- and Molecular-Pathway-Based Machine Learning Models for Neurological Disorder Diagnosis.

The process of identification and management of neurological disorder conditions faces challenges, prompting the investigation of novel methods in order to improve diagnostic accuracy. In this study, we conducted a systematic literature review to identify the significance of genetics- and molecular-pathway-based machine learning (ML) models in treating neurological disorder conditions. According to the study's objectives, search strategies were developed to extract the research studies using digital libraries. We followed rigorous study selection criteria. A total of 24 studies met the inclusion criteria and were included in the review. We classified the studies based on neurological disorders. The included studies highlighted multiple methodologies and exceptional results in treating neurological disorders. The study findings underscore the potential of the existing models, presenting personalized interventions based on the individual's conditions. The findings offer better-performing approaches that handle genetics and molecular data to generate effective outcomes. Moreover, we discuss the future research directions and challenges, emphasizing the demand for generalizing existing models in real-world clinical settings. This study contributes to advancing knowledge in the field of diagnosis and management of neurological disorders.

A Generalized Laser Simulator Algorithm for Mobile Robot Path Planning with Obstacle Avoidance.

This paper aims to develop a new mobile robot path planning algorithm, called generalized laser simulator (GLS), for navigating autonomously mobile robots in the presence of static and dynamic obstacles. This algorithm enables a mobile robot to identify a feasible path while finding the target and avoiding obstacles while moving in complex regions. An optimal path between the start and target point is found by forming a wave of points in all directions towards the target position considering target minimum and border maximum distance principles. The algorithm will select the minimum path from the candidate points to target while avoiding obstacles. The obstacle borders are regarded as the environment's borders for static obstacle avoidance. However, once dynamic obstacles appear in front of the GLS waves, the system detects them as new dynamic obstacle borders. Several experiments were carried out to validate the effectiveness and practicality of the GLS algorithm, including path-planning experiments in the presence of obstacles in a complex dynamic environment. The findings indicate that the robot could successfully find the correct path while avoiding obstacles. The proposed method is compared to other popular methods in terms of speed and path length in both real and simulated environments. According to the results, the GLS algorithm outperformed the original laser simulator (LS) method in path and success rate. With application of the all-direction border scan, it outperforms the A-star (A*) and PRM algorithms and provides safer and shorter paths. Furthermore, the path planning approach was validated for local planning in simulation and real-world tests, in which the proposed method produced the best path compared to the original LS algorithm.

Intellectual assessment of amyotrophic lateral sclerosis using deep resemble forward neural network.

ALS (Amyotrophic Lateral Sclerosis) is a neurodegenerative disorder causing profound physical disability that severely impairs a patient's life expectancy and quality of life. It also leads to muscular atrophy and progressive weakness of muscles due to insufficient nutrition in the body. At present, there are no disease-modifying therapies to cure ALS, and there is a lack of preventive tools. The general clinical assessments are based on symptom reports, neurophysiological tests, neurological examinations, and neuroimaging. But, these techniques possess various limitations of low reliability, lack of standardized protocols, and lack of sensitivity, especially in the early stages of disease. So, effective methods are required to detect the progression of the disease and minimize the suffering of patients. Extensive studies concentrated on investigating the causes of neurological disease, which creates a barrier to precise identification and classification of genes accompanied with ALS disease. Hence, the proposed system implements a deep RSFFNNCNN (Resemble Single Feed Forward Neural Network-Convolutional Neural Network) algorithm to effectively classify the clinical associations of ALS. It involves the addition of custom weights to the kernel initializer and neutralizer 'k' parameter to each hidden layer in the network. This is done to increase the stability and learning ability of the classifier. Additionally, the comparison of the proposed approach is performed with SFNN (Single Feed NN) and ML (Machine Learning) based algorithms, namely, NB (Naïve Bayes), XGBoost (Extreme Gradient Boosting) and RF (Random Forest), to estimate the efficacy of the proposed model. The reliability of the proposed algorithm is measured by deploying performance metrics such as precision, recall, F1 score, and accuracy.

Discriminant Input Processing Scheme for Self-Assisted Intelligent Healthcare Systems.

Modern technology and analysis of emotions play a crucial role in enabling intelligent healthcare systems to provide diagnostics and self-assistance services based on observation. However, precise data predictions and computational models are critical for these systems to perform their jobs effectively. Traditionally, healthcare monitoring has been the primary emphasis. However, there were a couple of negatives, including the pattern feature generating the method's scalability and reliability, which was tested with different data sources. This paper delves into the Discriminant Input Processing Scheme (DIPS), a crucial instrument for resolving challenges. Data-segmentation-based complex processing techniques allow DIPS to merge many emotion analysis streams. The DIPS recommendation engine uses segmented data characteristics to sift through inputs from the emotion stream for patterns. The recommendation is more accurate and flexible since DIPS uses transfer learning to identify similar data across different streams. With transfer learning, this study can be sure that the previous recommendations and data properties will be available in future data streams, making the most of them. Data utilization ratio, approximation, accuracy, and false rate are some of the metrics used to assess the effectiveness of the advised approach. Self-assisted intelligent healthcare systems that use emotion-based analysis and state-of-the-art technology are crucial when managing healthcare. This study improves healthcare management's accuracy and efficiency using computational models like DIPS to guarantee accurate data forecasts and recommendations.

Antidiabetic potential of fenugreek (Trigonella foenum-graecum): A magic herb for diabetes mellitus.

Fenugreek (Trigonella foenum-graecum) is a widely grown dietary herb in Asia, and its seeds are traditionally used for several diseases, including diabetes. The seeds and leaves possess a variety of compounds that play an important role in regulating their hypoglycemic effect. However, so far, no extensive systematic review exists on its antidiabetic effect, highlighting the molecular mechanisms and isolated compounds. The purpose of this review is to summarize the preclinical and clinical antidiabetic properties of fenugreek and its isolated compounds by focusing on underlying mechanisms. PubMed, Google Scholar, Science Direct, and Scopus databases were searched to retrieve articles until June, 2024. Preclinical studies demonstrated that the antidiabetic effect of fenugreek was mostly associated with enhanced glucose transporter type-4 (GLUT4) translocation and hexokinase activity, decreased glucose-6-phosphatase and fructose-1,6-bisphosphatase activities, inhibited α-amylase and maltase activities, protected ß cells, and increased insulin release. Furthermore, few studies have reported its role as a glucagon-like peptide-1 (GLP-1) modulator, 5'-AMP-activated kinase (AMPK) activator, and dipeptidyl peptidase-IV (DPP-IV) inhibitor. Further clinical trials showed that fenugreek seeds improved blood glucose levels, insulin resistance, insulin sensitivity, and lipid profiles. This study highlights significant evidence of the antidiabetic effect of fenugreek and its isolated compounds; therefore, it could be a potential therapy for diabetes.

Brain tumor segmentation using neuro-technology enabled intelligence-cascaded U-Net model.

According to experts in neurology, brain tumours pose a serious risk to human health. The clinical identification and treatment of brain tumours rely heavily on accurate segmentation. The varied sizes, forms, and locations of brain tumours make accurate automated segmentation a formidable obstacle in the field of neuroscience. U-Net, with its computational intelligence and concise design, has lately been the go-to model for fixing medical picture segmentation issues. Problems with restricted local receptive fields, lost spatial information, and inadequate contextual information are still plaguing artificial intelligence. A convolutional neural network (CNN) and a Mel-spectrogram are the basis of this cough recognition technique. First, we combine the voice in a variety of intricate settings and improve the audio data. After that, we preprocess the data to make sure its length is consistent and create a Mel-spectrogram out of it. A novel model for brain tumor segmentation (BTS), Intelligence Cascade U-Net (ICU-Net), is proposed to address these issues. It is built on dynamic convolution and uses a non-local attention mechanism. In order to reconstruct more detailed spatial information on brain tumours, the principal design is a two-stage cascade of 3DU-Net. The paper's objective is to identify the best learnable parameters that will maximize the likelihood of the data. After the network's ability to gather long-distance dependencies for AI, Expectation-Maximization is applied to the cascade network's lateral connections, enabling it to leverage contextual data more effectively. Lastly, to enhance the network's ability to capture local characteristics, dynamic convolutions with local adaptive capabilities are used in place of the cascade network's standard convolutions. We compared our results to those of other typical methods and ran extensive testing utilising the publicly available BraTS 2019/2020 datasets. The suggested method performs well on tasks involving BTS, according to the experimental data. The Dice scores for tumor core (TC), complete tumor, and enhanced tumor segmentation BraTS 2019/2020 validation sets are 0.897/0.903, 0.826/0.828, and 0.781/0.786, respectively, indicating high performance in BTS.

Brain-computer interfaces inspired spiking neural network model for depression stage identification.

BACKGROUND: Depression is a global mental disorder, and traditional diagnostic methods mainly rely on scales and subjective evaluations by doctors, which cannot effectively identify symptoms and even carry the risk of misdiagnosis. Brain-Computer Interfaces inspired deep learning-assisted diagnosis based on physiological signals holds promise for improving traditional methods lacking physiological basis and leads next generation neuro-technologies. However, traditional deep learning methods rely on immense computational power and mostly involve end-to-end network learning. These learning methods also lack physiological interpretability, limiting their clinical application in assisted diagnosis. METHODOLOGY: A brain-like learning model for diagnosing depression using electroencephalogram (EEG) is proposed. The study collects EEG data using 128-channel electrodes, producing a 128×128 brain adjacency matrix. Given the assumption of undirected connectivity, the upper half of the 128×128 matrix is chosen in order to minimise the input parameter size, producing 8,128-dimensional data. After eliminating 28 components derived from irrelevant or reference electrodes, a 90×90 matrix is produced, which can be used as an input for a single-channel brain-computer interface image. RESULT: At the functional level, a spiking neural network is constructed to classify individuals with depression and healthy individuals, achieving an accuracy exceeding 97.5 %. COMPARISON WITH EXISTING METHODS: Compared to deep convolutional methods, the spiking method reduces energy consumption. CONCLUSION: At the structural level, complex networks are utilized to establish spatial topology of brain connections and analyse their graph features, identifying potential abnormal brain functional connections in individuals with depression.

Bio-inspired deep learning-personalized ensemble Alzheimer's diagnosis model for mental well-being.

Most classification models for Alzheimer's Diagnosis (AD) do not have specific strategies for individual input samples, leading to the problem of easily overlooking personalized differences between samples. This research introduces a customized dynamically ensemble convolution neural network (PDECNN), which is able to build a specific integration strategy based on the distinctiveness of the sample. In this paper, we propose a personalized dynamic ensemble alzheimer's Diagnosis classification model. This model will dynamically modify the deteriorated brain areas of interest depending on various samples since it can adjust to variations in the degeneration of sample brain areas. In clinical problems, the PDECNN model has additional diagnostic importance since it can identify sample-specific degraded brain areas based on input samples. This model considers the variability of brain region degeneration levels between input samples, evaluates the degree of degeneration of specific brain regions using an attention mechanism, and selects and integrates brain region features based on the degree of degeneration. Furthermore, by redesigning the classification accuracy performance, we respectively improve it by 4 %, 11 %, and 8 %. Moreover, the degraded brain regions identified by the model show high consistency with the clinical manifestations of AD.

Artificial intelligence probabilities scheme for disease prevention data set construction in intelligent smart healthcare scenario.

In the face of an aging population, smart healthcare services are now within reach, thanks to the proliferation of high-speed internet and other forms of digital technology. Data problems in smart healthcare, unfortunately, put artificial intelligence in this area to serious limitations. There are several issues, including a lack of standard samples, noisy data interference, and actual data that is missing. A three-stage AI-based data generating strategy is suggested to handle missing datasets, using a small sample dataset obtained from a smart healthcare program community in a specific city: Step one involves generating the dataset's basic attributes using a tree-based generation strategy that takes the original data distribution into account. Step two involves using the Naive Bayes algorithm to create basic indicators of behavioural capability assessment for the samples. Step three builds on stage two and uses a multivariate linear regression method to create evaluation criteria and indicators of high-level behavioural capability. Six problems involving multiple classifications and two tasks using multiple labels are implemented using various neural network-based training strategies on the obtained data to assess the usefulness of the dataset for downstream tasks. To ensure that the data collected is genuine and useful, the experimental data must be analysed and expert knowledge must be included.

Feature fusion-based food protein subcellular prediction for drug composition.

The structure and function of dietary proteins, as well as their subcellular prediction, are critical for designing and developing new drug compositions and understanding the pathophysiology of certain diseases. As a remedy, we provide a subcellular localization method based on feature fusion and clustering for dietary proteins. Additionally, an enhanced PseAAC (Pseudo-amino acid composition) method is suggested, which builds upon the conventional PseAAC. The study initially builds a novel model of representing the food protein sequence by integrating autocorrelation, chi density, and improved PseAAC to better convey information about the food protein sequence. After that, the dimensionality of the fused feature vectors is reduced by using principal component analysis. With prediction accuracies of 99.24% in the Gram-positive dataset and 95.33% in the Gram-negative dataset, respectively, the experimental findings demonstrate the practicability and efficacy of the proposed approach. This paper is basically exploring pseudo-amino acid composition of not any clinical aspect but exploring a pharmaceutical aspect for drug repositioning.

Investigating the role of internet-based educational application in the dental sciences.

The study intended to identify the significance of the online information retrieval system (IRS) in evidence-based dentistry (EBD). Thus, the researchers apply a set of pre-and post-tests to evaluate the current knowledge of clinicians and students on online IRS. Materials and Methods: The researchers followed repeated measure design in this study. They applied random sampling technique for conducting pre-and post-test assessment. Five scenarios based EBD were developed to evaluate the performance of the participants. The researchers employed two phases in order to achieve the study's objective. In the first phase, 98 clinicians and 70 students were invited to attend three out of five clinical scenarios using IRS. In the second phase, the participants were invited to participate in a 15-min lecture presented by the researchers on the searching strategies and guidelines to apply keywords for searching the evidence using IRS. A significant level of p < 0.05 was obtained from the statistical analysis using the SPSS program version 16. Results: Of the 98 clinicians, only 37 responded to the questionnaire, with a response rate of 37.8 %. On the other hand, out of 70 students, 23 responded to the questionnaire, with a response rate of 32.8 %. In the pre-test, clinicians and students correctly answered 58.3 % of scenario questions. However, the data analysis outcome revealed that only 40.5 % of participants provided a relevant evidence source after an internet search. The students spent an average of 9 min to complete the task, whereas clinicians spent 16 min. After the completion of the lecture, 23 students and clinicians responded to the pre-test, whereas 10 responded to the post-test. Most students believed that the lecture was helpful and recommended similar types of lectures to be presented in the curriculum. The study findings highlight that the percentage of evidence provided in the "pre-test" was 60 %, which was improved in the post-test to 73.3 %. Conclusion: The experimental outcome suggests that internet-based educational applications enhance students' learning strategies. Additionally, the IRS supports clinicians in retrieving effective materials for treating their patients. Furthemore, there is a demand for extracurricular activity to improve the search strategies of clinicians and students to strengthen EBD.

Bio-inspired EEG signal computing using machine learning and fuzzy theory for decision making in future-oriented brain-controlled vehicles.

One kind of autonomous vehicle that can take instructions from the driver by reading their electroencephalogram (EEG) signals using a Brain-Computer Interface (BCI) is called a Brain-Controlled Vehicle (BCV). The operation of such a vehicle is greatly affected by how well the BCI works. At present, there are limitations on the accuracy of BCI recognition, the number of distinguishable command categories, and the execution duration of command recognition. Consequently, vehicles that are exclusively controlled by EEG signals demonstrate suboptimal control performance. To address the difficulty of improving the control capabilities of brain-controlled cars while maintaining BCI performance, a fuzzy logic-based technique called as Fuzzy Brain-Control Fusion Control is introduced. This approach uses Fuzzy Discrete Event System (FDES) supervisory theory to verify the accuracy of the driver's brain-controlled directives. Concurrently, a fuzzy logic-based automatic controller is developed to generate decisions automatically in accordance with the present state of the vehicle via fuzzy reasoning. The final decision is then reached through the application of secondary fuzzy reasoning to the accuracy of the driver's instructions and the automated decisions to make adjustments that are more consistent with human intent. A clever BCI gadget known as the Consistent State Visual Evoked Potential (SSVEP) is utilized to show the viability of the proposed technique. We recommend that additional research should be conducted at this time to confirm that our recommended system may further improve the control execution of BCI-fueled cars, regardless of whether BCIs have special limitations.

A systemic review on medicinal plants and their bioactive constituents against avian influenza and further confirmation through in-silico analysis.

Background: Avian influenza or more commonly known as bird flu is a widespread infectious disease in poultry. This review aims to accumulate information of different natural plant sources that can aid in combating this disease. Influenza virus (IV) is known for its ability to mutate and infect different species (including humans) and cause fatal consequences. Methods: Total 33 plants and 4 natural compounds were identified and documented. Molecular docking was performed against the target viral protein neuraminidase (NA), with some plant based natural compounds and compared their results with standard drugs Oseltamivir and Zanamivir to obtain novel drug targets for influenza in chickens. Results: It was seen that most extracts exhibit their action by interacting with viral hemagglutinin or neuraminidase and inhibit viral entry or release from the host cell. Some plants also interacted with the viral RNA replication or by reducing proinflammatory cytokines. Ethanol was mostly used for extraction. Among all the plants Theobroma cacao, Capparis Sinaica Veil, Androgarphis paniculate, Thallasodendron cillatum, Sinularia candidula, Larcifomes officinalis, Lenzites betulina, Datronia molis, Trametes gibbose exhibited their activity with least concentration (below 10 µg/ml). The dockings results showed that some natural compounds (5,7- dimethoxyflavone, Aloe emodin, Anthocyanins, Quercetin, Hemanthamine, Lyocrine, Terpenoid EA showed satisfactory binding affinity and binding specificity with viral neuraminidase compared to the synthetic drugs. Conclusion: This review clusters up to date information of effective herbal plants to bolster future influenza treatment research in chickens. The in-silico analysis also suggests some potential targets for future drug development but these require more clinical analysis.

Developing a Deep-Learning-Based Coronary Artery Disease Detection Technique Using Computer Tomography Images.

Coronary artery disease (CAD) is one of the major causes of fatalities across the globe. The recent developments in convolutional neural networks (CNN) allow researchers to detect CAD from computed tomography (CT) images. The CAD detection model assists physicians in identifying cardiac disease at earlier stages. The recent CAD detection models demand a high computational cost and a more significant number of images. Therefore, this study intends to develop a CNN-based CAD detection model. The researchers apply an image enhancement technique to improve the CT image quality. The authors employed You look only once (YOLO) V7 for extracting the features. Aquila optimization is used for optimizing the hyperparameters of the UNet++ model to predict CAD. The proposed feature extraction technique and hyperparameter tuning approach reduces the computational costs and improves the performance of the UNet++ model. Two datasets are utilized for evaluating the performance of the proposed CAD detection model. The experimental outcomes suggest that the proposed method achieves an accuracy, recall, precision, F1-score, Matthews correlation coefficient, and Kappa of 99.4, 98.5, 98.65, 98.6, 95.35, and 95 and 99.5, 98.95, 98.95, 98.95, 96.35, and 96.25 for datasets 1 and 2, respectively. In addition, the proposed model outperforms the recent techniques by obtaining the area under the receiver operating characteristic and precision-recall curve of 0.97 and 0.95, and 0.96 and 0.94 for datasets 1 and 2, respectively. Moreover, the proposed model obtained a better confidence interval and standard deviation of [98.64-98.72] and 0.0014, and [97.41-97.49] and 0.0019 for datasets 1 and 2, respectively. The study's findings suggest that the proposed model can support physicians in identifying CAD with limited resources.

Modified Meta Heuristic BAT with ML Classifiers for Detection of Autism Spectrum Disorder.

ASD (autism spectrum disorder) is a complex developmental and neurological disorder that impacts the social life of the affected person by disturbing their capability for interaction and communication. As it is a behavioural disorder, early treatment will improve the quality of life of ASD patients. Traditional screening is carried out with behavioural assessment through trained physicians, which is expensive and time-consuming. To resolve the issue, several conventional methods strive to achieve an effective ASD identification system, but are limited by handling large data sets, accuracy, and speed. Therefore, the proposed identification system employed the MBA (modified bat) algorithm based on ANN (artificial neural networks), modified ANN (modified artificial neural networks), DT (decision tree), and KNN (k-nearest neighbours) for the classification of ASD in children and adolescents. A BA (bat algorithm) is utilised for the automatic zooming capability, which improves the system's efficacy by excellently finding the solutions in the identification system. Conversely, BA is effective in the identification, it still has certain drawbacks like speed, accuracy, and falls into local extremum. Therefore, the proposed identification system modifies the BA optimisation with random perturbation of trends and optimal orientation. The dataset utilised in the respective model is the Q-chat-10 dataset. This dataset contains data of four stages of age groups such as toddlers, children, adolescents, and adults. To analyse the quality of the dataset, dataset evaluation mechanism, such as the Chi-Squared Statistic and p-value, are used in the respective research. The evaluation signifies the relation of the dataset with respect to the proposed model. Further, the performance of the proposed detection system is examined with certain performance metrics to calculate its efficiency. The outcome revealed that the modified ANN classifier model attained an accuracy of 1.00, ensuring improved performance when compared with other state-of-the-art methods. Thus, the proposed model was intended to assist physicians and researchers in enhancing the diagnosis of ASD to improve the standard of life of ASD patients.

Artificial intelligence-driven malware detection framework for internet of things environment.

The Internet of Things (IoT) environment demands a malware detection (MD) framework for protecting sensitive data from unauthorized access. The study intends to develop an image-based MD framework. The authors apply image conversion and enhancement techniques to convert malware binaries into RGB images. You only look once (Yolo V7) is employed for extracting the key features from the malware images. Harris Hawks optimization is used to optimize the DenseNet161 model to classify images into malware and benign. IoT malware and Virusshare datasets are utilized to evaluate the proposed framework's performance. The outcome reveals that the proposed framework outperforms the current MD framework. The framework generates the outcome at an accuracy and F1-score of 98.65 and 98.5 and 97.3 and 96.63 for IoT malware and Virusshare datasets, respectively. In addition, it achieves an area under the receiver operating characteristics and the precision-recall curve of 0.98 and 0.85 and 0.97 and 0.84 for IoT malware and Virusshare datasets, accordingly. The study's outcome reveals that the proposed framework can be deployed in the IoT environment to protect the resources.

Chaotic Sparrow Search Algorithm with Deep Transfer Learning Enabled Breast Cancer Classification on Histopathological Images.

Breast cancer is the major cause behind the death of women worldwide and is responsible for several deaths each year. Even though there are several means to identify breast cancer, histopathological diagnosis is now considered the gold standard in the diagnosis of cancer. However, the difficulty of histopathological image and the rapid rise in workload render this process time-consuming, and the outcomes might be subjected to pathologists' subjectivity. Hence, the development of a precise and automatic histopathological image analysis method is essential for the field. Recently, the deep learning method for breast cancer pathological image classification has made significant progress, which has become mainstream in this field. This study introduces a novel chaotic sparrow search algorithm with a deep transfer learning-enabled breast cancer classification (CSSADTL-BCC) model on histopathological images. The presented CSSADTL-BCC model mainly focused on the recognition and classification of breast cancer. To accomplish this, the CSSADTL-BCC model primarily applies the Gaussian filtering (GF) approach to eradicate the occurrence of noise. In addition, a MixNet-based feature extraction model is employed to generate a useful set of feature vectors. Moreover, a stacked gated recurrent unit (SGRU) classification approach is exploited to allot class labels. Furthermore, CSSA is applied to optimally modify the hyperparameters involved in the SGRU model. None of the earlier works have utilized the hyperparameter-tuned SGRU model for breast cancer classification on HIs. The design of the CSSA for optimal hyperparameter tuning of the SGRU model demonstrates the novelty of the work. The performance validation of the CSSADTL-BCC model is tested by a benchmark dataset, and the results reported the superior execution of the CSSADTL-BCC model over recent state-of-the-art approaches.

Intelligent Deep-Learning-Enabled Decision-Making Medical System for Pancreatic Tumor Classification on CT Images.

Decision-making medical systems (DMS) refer to the design of decision techniques in the healthcare sector. They involve a procedure of employing ideas and decisions related to certain processes such as data acquisition, processing, judgment, and conclusion. Pancreatic cancer is a lethal type of cancer, and its prediction is ineffective with current techniques. Automated detection and classification of pancreatic tumors can be provided by the computer-aided diagnosis (CAD) model using radiological images such as computed tomography (CT) and magnetic resonance imaging (MRI). The recently developed machine learning (ML) and deep learning (DL) models can be utilized for the automated and timely detection of pancreatic cancer. In light of this, this article introduces an intelligent deep-learning-enabled decision-making medical system for pancreatic tumor classification (IDLDMS-PTC) using CT images. The major intention of the IDLDMS-PTC technique is to examine the CT images for the existence of pancreatic tumors. The IDLDMS-PTC model derives an emperor penguin optimizer (EPO) with multilevel thresholding (EPO-MLT) technique for pancreatic tumor segmentation. Additionally, the MobileNet model is applied as a feature extractor with optimal auto encoder (AE) for pancreatic tumor classification. In order to optimally adjust the weight and bias values of the AE technique, the multileader optimization (MLO) technique is utilized. The design of the EPO algorithm for optimal threshold selection and the MLO algorithm for parameter tuning shows the novelty. A wide range of simulations was executed on benchmark datasets, and the outcomes reported the promising performance of the IDLDMS-PTC model on the existing methods.

Barnacles Mating Optimizer with Deep Transfer Learning Enabled Biomedical Malaria Parasite Detection and Classification.

Biomedical engineering involves ideologies and problem-solving methods of engineering to biology and medicine. Malaria is a life-threatening illness, which has gained significant attention among researchers. Since the manual diagnosis of malaria in a clinical setting is tedious, automated tools based on computational intelligence (CI) tools have gained considerable interest. Though earlier studies were focused on the handcrafted features, the diagnostic accuracy can be boosted through deep learning (DL) methods. This study introduces a new Barnacles Mating Optimizer with Deep Transfer Learning Enabled Biomedical Malaria Parasite Detection and Classification (BMODTL-BMPC) model. The presented BMODTL-BMPC model involves the design of intelligent models for the recognition and classification of malaria parasites. Initially, the Gaussian filtering (GF) approach is employed to eradicate noise in blood smear images. Then, Graph cuts (GC) segmentation technique is applied to determine the affected regions in the blood smear images. Moreover, the barnacles mating optimizer (BMO) algorithm with the NasNetLarge model is employed for the feature extraction process. Furthermore, the extreme learning machine (ELM) classification model is employed for the identification and classification of malaria parasites. To assure the enhanced outcomes of the BMODTL-BMPC technique, a wide-ranging experimentation analysis is performed using a benchmark dataset. The experimental results show that the BMODTL-BMPC technique outperforms other recent approaches.

An ML-Enabled Internet of Things Framework for Early Detection of Heart Disease.

Healthcare occupies a central role in sustainable societies and has an undeniable impact on the well-being of individuals. However, over the years, various diseases have adversely affected the growth and sustainability of these societies. Among them, heart disease is escalating rapidly in both economically settled and undeveloped nations and leads to fatalities around the globe. To reduce the death ratio caused by this disease, there is a need for a framework to continuously monitor a patient's heart status, essentially doing early detection and prediction of heart disease. This paper proposes a scalable Machine Learning (ML) and Internet of Things-(IoT-) based three-layer architecture to store and process a large amount of clinical data continuously, which is needed for the early detection and monitoring of heart disease. Layer 1 of the proposed framework is used to collect data from IoT wearable/implanted smart sensor nodes, which includes various physiological measures that have significant impact on the deterioration of heart status. Layer 2 stores and processes the patient data on a local web server using various ML classification algorithms. Finally, Layer 3 is used to store the critical data of patients on the cloud. The doctor and other caregivers can access the patient health conditions via an android application, provide services to the patient, and inhibit him/her from further damage. Various performance evaluation measures such as accuracy, sensitivity, specificity, F1-measure, MCC-score, and ROC curve are used to check the efficiency of our proposed IoT-based heart disease prediction framework. It is anticipated that this system will assist the healthcare sector and the doctors in diagnosing heart patients in the initial phases.