RESUMO
BACKGROUND: Surgical videos coupled with structured assessments enable surgical training programs to provide independent competency evaluations and align with the American Board of Surgery's entrustable professional activities initiative. Existing assessment instruments for minimally invasive inguinal hernia repair (IHR) have limitations with regards to reliability, validity, and usability. A cross-sectional study of six surgeons using a novel objective, procedure-specific, 8-item competency assessment for minimally invasive inguinal hernia repair (IHR-OPSA) was performed to assess inter-rater reliability using a "safe" vs. "unsafe" scoring rubric. METHODS: The IHR-OPSA was developed by three expert IHR surgeons, field tested with five IHR surgeons, and revised based upon feedback. The final instrument included: (1) incision/port placement; (2) dissection of peritoneal flap (TAPP) or dissection of peritoneal flap (TEP); (3) exposure; (4) reducing the sac; (5) full dissection of the myopectineal orifice; (6) mesh insertion; (7) mesh fixation; and (8) operation flow. The IHR-OPSA was applied by six expert IHR surgeons to 20 IHR surgical videos selected to include a spectrum of hernia procedures (15 laparoscopic, 5 robotic), anatomy (14 indirect, 5 direct, 1 femoral), and Global Case Difficulty (easy, average, hard). Inter-rater reliability was assessed against Gwet's AC2. RESULTS: The IHR-OPSA inter-rater reliability was good to excellent, ranging from 0.65 to 0.97 across the eight items. Assessments of robotic procedures had higher reliability with near perfect agreement for 7 of 8 items. In general, assessments of easier cases had higher levels of agreement than harder cases. CONCLUSIONS: A novel 8-item minimally invasive IHR assessment tool was developed and tested for inter-rater reliability using a "safe" vs. "unsafe" rating system with promising results. To promote instrument validity the IHR-OPSA was designed and evaluated within the context of intended use with iterative engagement with experts and testing of constructs against real-world operative videos.
Assuntos
Hérnia Inguinal , Laparoscopia , Procedimentos Cirúrgicos Robóticos , Humanos , Hérnia Inguinal/cirurgia , Estudos Transversais , Reprodutibilidade dos Testes , Procedimentos Cirúrgicos Robóticos/métodos , Herniorrafia/métodos , Telas CirúrgicasRESUMO
During the months of December, 1970 and January, 1971, a large number of patients admitted to the San Fernando General Hospital with acute glomerulonephritis presented with skin lesions characteristic of scabies. During this period there was also an increase in the number of admissions for acute glomerulonephritis as compared with the same months in the inter-epidemic years. This has been associated with an outbreak of scabies maninly in South Trinidad. Beta hemolytic streptococci were isolated from scabies lesions in patients with acute glomerulonephritis, in nephritic families, in school children and in the residents of an affected village. The main types of beta hemolytic streptococci are described with special reference to their significance. Concomitantly it was observed that an increasing number of dogs in nephritic households had skin lesions ("mange") suggestive of scabies. The beta hemolytic streptococci isolated from the dogs are also described. The authors call attention to the fact that patients with rheumatic fever admitted to hospital during the same period were remarkably free from both scabies and skin sores and that there has been no previous published report of an outbreak of acute glomerulonephritis associated with scabies (AU)
Assuntos
Humanos , 21003 , Cães , Escabiose , Infecções Estreptocócicas , Glomerulonefrite , Trinidad e TobagoRESUMO
An Intensive Streptococcal Surveillance of two South Trinidad Schools differing in topographical surroundings and ethnic composition has been done for five months. Throat and skin sore cultures were obtained from samples of children of volunteer families. Additional cultures were obtained from non-sample schoolmates who developed skin sores. The data and findings are as follows: 1. Skin sores were found mainly on the extremities. 2. Males have more skin sores than females in a ratio of over 2:1 for males versus females. 3. The highest incidence of skin sores, was found in the five to six (5-6) year old population. 4. In the school sample 22.7 percent developed skin sore, 68.8 percent were positive for Beta-hemolytic Streptococci and 79.4 percent were Group-A. 5. 78.9 percent of all skin sores contained Beta-hemolytic Streptococci. 6. 77.3 percent of Beta-hemolytic Streptococci were Group-A. 7. The prevalence and incidence of skin sores, Beta-hemolytic Streptococci and Group-A Streptococci was highest at the end of December. (The end of the wet season). 8. 18.7 percent of the subject studied had Beta-hemolytic Streptococci in their throats; of these 25.4 percent were Group-A. 9. Of other streptococcal groups - throat cultures were high in Group-G while skin sores were high in Group-C. 10. The mean length of time that Beta-hemolytic Streptococci remained in skin sore was four (4) weeks. Sores themselves may be the reservoir for Group-A Streptococci. 11. The mean length of time that Beta-hemolytic Streptococci remained in the throat was two (2) weeks(Summary)
Assuntos
Humanos , Feminino , Masculino , Infecções Estreptocócicas/epidemiologia , Dermatopatias Infecciosas/epidemiologia , Trinidad e Tobago/epidemiologiaRESUMO
Streptococcal infections have been studied in South Trinidad during and for five years following a major epidemic of acute glomerulonephritiis (AGN). Many of these infections have been in the skin, especially in children in the rural areas. The relation of these infections to acute rheumatic fever (ARF) also has been examined with the following conclusions: During the mafor epidemic of AGN in 1964 and 1965, the incidence, of ARF decreased. This is in accordance with the current hypothesis that rheumatogenic streptococcal strains rarely are nephritgenic and vice versa. Since 1966, however, three increases in incidence of AGN have been accompanied by modest increases in the incidence of ARF. The streptococcal strains isolated from patients with ARF usually were not of the types concurrently isolated from patients with AGN. Moreover the lack of skin infections in the patients with ARF is striking in comparison with "normal" school children as well as with patients with AGN. Antristreptolysin O (ASO) titres in patients with ARF, as with AGN, increased only slightly or not at all while antithyaluroindase titres increased to similar high values in patients with both AGN and ARF. The lack of increased ASO titres in patients with ARF is in control to observations in other geographic areas where they consistently have been high. The lack of increased ASO titres in patients with AGN in Trinidad, as in other areas where AGN is associated with skin infections, has been attributed to the site of infections. However, no cases of ARF have been definitely related to skin infections in Trinidad or elsewhere (AU)
Assuntos
Humanos , Febre Reumática/epidemiologia , Trinidad e Tobago , Infecções EstreptocócicasRESUMO
A study was undertaken to estimate the frequency of subclinical glomerulonephritis in the families of patients admitted with acute glomerulonephritis to San Fernando General Hospital. The findings are expected to bear on the question of the etiology of cases of prolifertive diffuse chronic glomerulonephritis where no history is found of an acute episode. One thousand five hundred members of immediate families of patients admitted during the past year were visited within 31 days of the admission. Incidental urines in 10 percent had hematuria or proteinuria by Hemacomistix. These were examined weekly and had urinalyses, urine, throat, and skin cultures and Beta-1-C globulin and ASO determinations. For comparison 1,300 children aged 5-14 from four South Trinidad schools were tested. All with urinary abnormalities and an equal number of controls had urines repeated and Beta-1-C determinations. No school children had clinically manifest nephritis. Among nephritis family school aged children with urinary abnormalities, none were hypertensive, and edema or low complement was uncommon. The proportion of the remainder whose urinary abnormalities can be attributed to nephritis is estimated by comparing with age-specific and type of abnormality specific rates in the control school children. Hematuria was enough more common in nephritis family children that it can usually be attributed to nephritis. The subclinical: clinical case ratio ascertained this way in immediate families in South Trinidad would seem to be less than 1:1(AU)
Assuntos
Humanos , Criança , Glomerulonefrite/etiologia , Trinidad e TobagoRESUMO
These findings represented a study covering a period of ca. 5 months beginning September 1966. In this time, 75 cases of acute glomerulonephritis were investigated. Skin lesions of these patients were examined for B-hemolytic streptococci and coagulase-positive staphylococci. The families of the patients, totalling 486 individuals (exclusive of the patients) were similarly studied. Patients were cultured immediately on admission to hospital while their families were cultured usually within 4-5 days of admission of the patient. The majority of the lesions were traumatic in origin being the result of arthropod bites, cuts and bruises. Lesions were far more prevalent on the legs than elsewhere. Together, the legs and arms accounted for 90 percent and more of the lesions, 41.3 percent of the patients had lesions, this being twice the rate amongst the families .The occurrence of streptococci alone or staphylococci alone were rare events. However, the occurrence of staphylococci or streptococci in a skin lesion were independent events. Amongst cases, streptococci were found in 67.7 percent of the skin lesion, staphylococci in 93.5 percent, both organisms being found together in 61.3 percent. Comparable figures for the family group 66.0 percent, 74.2 percent, and 52.6 percent respectively. In both patients and families, skin sore if they contained streptococci, then the chances were high that the organisms would be Group A. Coagulase-positive staphylococci were found to occupy all categories with respect to pigmentation and heamolysis of sheep RBC, namely, white non-haemolytic, white haemolytic, golden heamolytic and the most common golden haemolytic. Haemolysis of sheep RBC and pigmentation of staphylococci did not influence the independence of staphylococci and streptococci. We were unable to commit ourselves as to whether staphylococci played any specific role in the aetiology or the course of the illness. Several hypotheses were suggested, for example, a synergestic action between staphylococcal products and streptococcal antigens, genome exchange between staphylococci and streptococci inducing nephritogenicity in the streptococci and immobilization of host defences by staphylococci leaving the host open to streptococcal attack. It was suggested that since skin sores acted as reservoirs for streptococci, antibiotic therapy of individuals with skin sores could control the disease. We point out that the widespread presence of staphylococci constituted a factor of immense importance to be considered in any prophylaxis and control programme. Any large-scale control programme using antibiotics could be expected to lead to the emergence of resistant staphylococci which would not only nullify the programme but would lead to other public health problems (AU)
Assuntos
Dermatopatias Infecciosas , Glomerulonefrite , Trinidad e TobagoRESUMO
The Streptococcal Disease Unit of San Fernando, Trinidad, is a part of the National Nephritis Control Programme of the Ministry of Health of Government of Trinidad and Tobago. During the last fiscal year the Unit has reconstructed the descriptive epidemiology of recent acute glomerulonephritis and acute rheumatic fever. It has also investigated and followed up hospital cases of acute nephritis, visited families of nephritics, and kept under surveillance a probability sample of South Trinidad families and two schools. The 1965 acute nephritis epidemic wave in South Trinidad was bimodal and contained over 1,000 cases. The wave began in August (1964) crested in February, throughed in June, and recrested in September before descending to the former endemic level. Acute rheumatic fever followed a paradoxical course with 1964 admissions significantly exceeding 1965 admissions. Acute nephritis was most common in preschool children, males, East Indians. No primary geographic focus for the epidemic could be discovered. Analysis of socioeconomic facets of 1966 cases revealed that nephritis families were larger, had more preschool children, earned less, were more crowded, and more rural. On the other hand, nephritis and surveillance families did not differ in housing quality, nearby agriculture, or water supply. When antistreptolysin O titers among nephritis families and cases are compared to the surveillance population, titers among cases and their families are distinctly higher. Bouts of skin sores frequently preceded acute nephritis but not acute rheumatic fever. Age adjusted skin sore prevalence is significant greater among nephritis families than among surveillance families. Skin sores are most prevalent in preschool children and are unusual after age 15. Five per cent of all studied individuals have group A beta hemolytic streptococci in the pharynx. However, group a streptococci from skin sores, as well as skin sores, are significantly more prevalent in nephritis patients and members of their families. Skin sores harbour over one-half the group A streptococci present in the general population, over three-quarters among nephritis families, and over four-fifths among nephritis patients. Skin sore group A streptococci are largely if not completely independent of group A streptococci in the pharynx or external nares. This independence is not a feature of colonization by group C or group G streptococci. The external nares are infrequently colonized with group A streptococci. Pharyngeal colonization is short-lived but skin sores of a single individual may contain group A streptococci for several months. Thus, skin sores are the most important reservoir of group A streptococci in the studied population (see later paper). Genesis of skin sore pivots about arthropod bites, (i.e. mosquitoes, sandflies,) and host hypersensitivity. Bacterial invasion of skin sores results from direct contact with another infected person or from feeding flies of the genus Hippelates. Skin sores cannot be prevented but invasion by group A streptococci may be preventable. Thus most acute nephritis also may be preventable. Subsequent investigations of the unit wil be devoted towards the goal of preventing group A streptococcal colonization of skin sores (AU)
Assuntos
Lactente , Pré-Escolar , Criança , Humanos , Glomerulonefrite/epidemiologia , Dermatopatias Infecciosas/epidemiologia , Infecções Estreptocócicas , Trinidad e TobagoRESUMO
The families of 21 patients with acute rheumatic fever (ARF) and 44 patients with acute glomerulonephritis (AGN) in Trinidad were examined in their homes. The ARF and AGN families were equally large and crowded and they lived in the same largely rural areas. However, only 22 percent of the ARF family members had skin infections in contrast to 61 percent of the AGN family members. Sixty-eight per cent of skin infections in ARF families and 69 percent of skin infection in AGN families yielded group A streptococci. Throat cultures were positive in 19 percent of ARF family members and 25 percent of AGN family members. Thirty-two per cent of 51 group A strains isolated from ARF family members (29 from throat, 22 from skin) were M11 of "M41" strains which were associated with ARF during the study, while only 8 percent were M1, T4 (MNT or 60) or M55 strains which were associated with AGN. In contrast, 49 percent of 171 group A strains isolated from AGN family members (64 from throat, 107 from skin) were M1, T4 (MNT or 60) of M55 while only 10 percent were M11 of "M41." Serum antibody titres were similar in both groups: antistreptolysin-0 titres were not markedly increased in either while anti-hyaluronidase and/or antideoxyribonuclease-B titres were increased in both. Evidence of subclinical AGN was found equally often in both groups: 6 percent of each had abnormal urine and 4 percent of each had decreased serum complement while 2 percent of the ARF and 3 percent of the AGN family members had both abnormal urine and decreased serum complement.(AU)
Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Febre Reumática/epidemiologia , Febre Reumática/genética , Glomerulonefrite/epidemiologia , Glomerulonefrite/genética , Resumo em Inglês , Habitação , Faringite/epidemiologia , População Rural , Dermatopatias/epidemiologia , Infecções Estreptocócicas/epidemiologia , Trinidad e TobagoRESUMO
In September, 1970, an increasing number of the patients admitted with acute glomerulonephritis to San Fernado General Hospital in Trinidad were noted to have skin lesions characteristic of scabies. á-haemolytic streptococci were isolated from these lesions and also from similar scabetic lesions in members of the patients' families, in " normal" schoolchildren, and in the general population of a small village. Concomitantly, many dogs in nephritic households, as well as others running wild, were observed to have lesions compatible with scabies from which á-haemolytic streptococci also were isolated. Sarcoptes scabiei were indentified in lesions of both patients and dogs and were morphologically indentical. After the onset of this infestation with scabies, the admission-rate of patients with acute proportions which have proved, since this study, to be the beginning of the largest epidemic of acute glomerulonephritis yet recorded in Trinidad.(AU)
Assuntos
Humanos , Criança , Adulto , Cães , 21003 , Glomerulonefrite/etiologia , Escabiose/complicações , Escabiose/epidemiologia , Surtos de Doenças , Doenças do Cão/microbiologia , Glomerulonefrite/epidemiologia , Escabiose/sangue , Escabiose/microbiologia , Escabiose/urina , Soroglobulinas/análise , Dermatopatias Infecciosas/complicações , Infecções Estreptocócicas/complicações , Streptococcus/isolamento & purificação , Trinidad e TobagoRESUMO
Twenty-seven strains of beta hemolytic streptococci from patients with acute glomerulonephritis and 212 strains from school children were isolated in Trinidad during an epidemic of nephritis involving over 1,000 patients. Sixty-two per cent of the 27 strains from nephritic patients and 3 strains from school children belonged to an apparently new serotype referred to here as Trinidad type A. Type-specific antibodies against this type were found in 50 per cent of 56 patients 1 to 3 months after acute glomerulonephritis. Six of the 10 remaining strains from patients with nephritis and 34 strains from school children were characterized as a second new type B. This strain contained M protein of provisional type Schoenborn isolated from pyoderma in Red Lake, Minnesota. It also contained a second antigen found in some type 41 strains of streptococci. Studies of temperate bacteriophage related to these strains suggested a possible association with nephritis in a negative way. With one exception, streptococci strains from nephritic patients were not lysogenic, while antiphage activity was observed in sera from 72 per cent of 50 patients. Moreover, 33 per cent of 86 strains from school children in areas where nephritis was occurring were lysogenic, while only 3 of 46 strains from areas without nephritis contained bacteriophage.(AU)
Assuntos
Humanos , Criança , Adulto , Masculino , Feminino , Glomerulonefrite/microbiologia , Streptococcus/classificação , Doença Aguda , Anticorpos/análise , Antígenos/análise , Bacteriófagos/análise , Surtos de Doenças , Nefrite/microbiologia , Serviços de Saúde Escolar , Streptococcus/análise , Streptococcus/isolamento & purificação , Trinidad e TobagoRESUMO
A large epidemic of acute glomerulonephritis occurred in South Trinidad in 1971, the fourth since 1952. Seven hundred and forty-three (743) cases were admitted to the San Fernando hospital during the year. After a high endemic period during the first 5 months, an epidemic broke out in June, 1971 and 598 patients were admitted with acute glomerulonephritis from June to the first week of December. This coincided with an epidemic of scabies in the island. Fifty-five per cent of the patients had scabies with secondary infection. Pyoderma was found in 441 patients (43.7 percent). Sixty-one families had more than one case of acute nephritis. Laboratory investigation included cultures of the skin and throat, grouping and typing of the streptococci, serial estimations of compliment (BIC), Antistreptolysin O titre, BUN and weekly urinalysis. Group A Beta haemolytic streptococci were isolated from 434 patients (73 percent). There were 335 positive cultures from skin sores and 278 from the throat. One hundred and seventy-nine (179) patients had Beta haemolytic streptococci in both skin sores and throat. Of the strains that were M-typed, 245 (60.6 percent) were M-typed 55. T-typing of the streptococci showed that 78.3 percent agglutinated with all the pools (T, U, W, X, Y, and Z). Type 55 streptococcus was first discovered in Trinidad in 1965 and its re-appearance with the 1971 epidemic confirms its nephritogenicity. In marked contrast, there was no increase in the number of cases of acute rheumatic fever, although these patients came from the same socio-economic group and the same areas affected by the epidemic of post-streptococcal acute glomerulonephritis (AU)
Assuntos
Humanos , Glomerulonefrite/epidemiologia , Streptococcus , Escabiose/epidemiologia , Glomerulonefrite/epidemiologia , Trinidad e Tobago/epidemiologiaRESUMO
We will present bacteriological evidence for an association of acute glomerulonephritis with several streptococcal strains isolated from skin lesions in Trinidad; Types 52 and 55 during the first wave and type 49 during the second wave of the 1964-65 epidemic; atypical "type 2" in a sub-epidemic rise in cases during an endemic year; type 57 during a subsequent epidemic period; and type 60 most recently. Immunological confirmation of association of these strains with acute glomerulonephritis was obtained only for type 55. Low incidence of serum type specific antibodies to types 49 and "type 2" may be attribued to their poor antigenicity. However, this is not the case with type 57. Emergence of at least five and perhaps six apparently new types of nephritogenic streptococci during a relatively short period suggests that each recurrent epidemic wave of acute nephritis is the result of a newly introduced or newly developed strain of nephritogenic streptococci. Several questions might be asked: From where do these different types come?. Are they brought into Trinidad from outside or do they represent local mutants? Does a skin infection represent a particularly suitable environment for development of new streptococcal antigens? (AU)
Assuntos
Humanos , Glomerulonefrite/etiologia , Infecções Estreptocócicas/complicações , Dermatopatias Infecciosas/complicações , Trinidad e TobagoRESUMO
We have presented bacteriological evidence for an association of acute glomerulonephritis with several streptococcal strains isolated from skin lesions in Trinidad: Types 52 and 55 during the first wave and type 49 during the second wave of the 1964-65 epidemic; atypical "type 2" in a sub-epidemic rise in cases during an endemic year; type 57 during a subsequent epidemic period; and type 60 most recently. Immunological confirmation of association of these strains with acute glomerulonephritis was obtained only for type 55. Low incidence of serum type specific antibodies to types 49 and "type 2" may be attributed to their poor antigenicity. However, this is not the case with type 57. Emergence of at least five and perhaps six apparently new types of nephritogenic streptococci during a relatively short period suggests that each recurrent epidemic wave of acute nephritis is the result of a newly introduced or newly developed strain of nephritogenic streptococci. Several questions might be asked: From where do these different types come? Does a skin infection represent a particularly suitable environment for development of new streptococcal antigens? (Summary)
Assuntos
Humanos , Criança , Adulto , Masculino , Feminino , Glomerulonefrite/etiologia , Dermatopatias/complicações , Infecções Estreptocócicas/complicações , Doença Aguda , Anticorpos/análise , Biópsia , Surtos de Doenças , Glomerulonefrite/epidemiologia , Glomerulonefrite/microbiologia , Testes de Hemaglutinação , Microscopia Eletrônica , Microscopia de Fluorescência , Dermatopatias/epidemiologia , Dermatopatias/microbiologia , Infecções Estreptocócicas/epidemiologia , Infecções Estreptocócicas/microbiologia , Streptococcus/isolamento & purificação , Técnicas de Cultura , Trinidad e TobagoRESUMO
Incidental urines from 2019 members of the family households of 369 patients hospitalized wih acute glomerulonephritis, 1605 residents of a village, and 1299 school-children were tested with Hema-Combistix. (In this report, the family of a patient is termed a nephritis family.) Hematuria was more frequent in nephritis family members under 10 years old than in similiar control subjects. Proteinuria was more frequent in nephritis family members aged 10 to 30 and 40 to 60 years than in similiar village residents. The control school-children (tested at school) had proteinuria more frequently than did nephritis family children (tested at home). Urine abnormalities were found in 219 of the nephritis family members. Subtracting similiar urine abnormalities found in the control groups from those of the nephritis family members leaves 98 of these abnormalities presumably attributed to family asociation with currently hospitalized cases of acute nephritis. Serum á-1-C gloulin was decreased in 16 of the nephritis family members with urine abnormalities and in only one of 207 subjects from the control groups. Decreased serum á-1-C globulin was associated with mild stigmata of acute glomerulonephritis in the nephritis family members (AU)
Assuntos
Humanos , Recém-Nascido , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Glomerulonefrite/epidemiologia , Doença Aguda , Fatores Etários , beta-Globulinas/análise , Glomerulonefrite/diagnóstico , Glomerulonefrite/genética , Hematúria/diagnóstico , Hematúria/epidemiologia , Hematúria/imunologia , Hospitalização , Imunodifusão , Índia , Proteinúria/diagnóstico , Proteinúria/epidemiologia , Proteinúria/imunologia , Trinidad e TobagoRESUMO
The incidence of acute rheumatic fever decreased during a major epidemic of acute glomerulonephritis in Trinidad in 1965. Subsequently, several minor increases in the incidence of acute rheumatic fever have been coincident with more marked increases in the incidence of acute glomerulonephritis. The relation of streptococcal infections to acute glomerulonephritis has been studied in Trinidad for the past six years. Their relation to acute rheumatic fever also has been examined during the last year of these studies. The streptococcal strains isolated from patients with acute rheumatic fever generally have differed from those found in patients with acute glomerulonephritis. Moreover, while streptococcal skin infections have been associated with acute glomerulonephritis, no such association has been apparent with rheumatic fever. However, titers of antistreptolysin O were relatively low, while titers of antihyaluronidase were makedly increased in the patients with acute rheumatic fever, much as they have been in most patients with acute glomerulonephritis in Trinidad (AU)
Assuntos
Humanos , Glomerulonefrite/complicações , Febre Reumática/complicações , Anticorpos , Antiestreptolisina/análise , Glomerulonefrite/imunologia , Hialuronoglucosaminidase/antagonistas & inibidores , Imunoglobulinas/análise , Febre Reumática/imunologia , Dermatopatias/complicações , Dermatopatias/imunologia , Streptococcus/isolamento & purificação , Trinidad e TobagoRESUMO
Patients with nephritis and schoolchildren in South Trinidad were surveyed for the presence of Corynebacterium diphtheriae in throats and skin lesions. The incidence of positive cultures was higher in skin leisons than in throat cultures. None of the children experienced symptoms of systemic intoxication. Subsequent to the increase in cutaneous infections, however, the indidence of symptomatic nasopharyngeal diphtheria also increased in Trinidad, suggesting that the skin lesions constituted an important reservior of infection. One group of schoolchildren was reexamined after six months, and the levels of antitoxin in serum were correlated with the presence of C. diphtheriae in skin leisons and throat cultures. The high levels of antitoxins observed apparently resulted from natural immunization in the absence of clinical signs of diphtheria. No effect of C. diphtheriae was noted on the colonization of skin lesions by streptocci or on the incidence of acute glomerulonephritis in the population. (AU)
Assuntos
Criança , Humanos , Difteria/epidemiologia , Serviços de Saúde Escolar , Dermatopatias Infecciosas/epidemiologia , Corynebacterium diphtheriae/isolamento & purificação , Difteria/complicações , Difteria/imunologia , Imunidade Ativa , /imunologia , Dermatopatias , Trinidad e Tobago , Infecções EstreptocócicasRESUMO
An unusually large epidemic of acute glomerulonephritis occurred in Trinidad, the third outbreak on that island in fifteen years. Clinical and laboratory observations on 681 cases in South Trinidad are presented in this report. These data indicated that the majority of cases were poststreptococcal acute glomerulonephritis, associated with impetiginous sores, which are common among children in Trinidad. (AU)
Assuntos
Humanos , Lactente , Pré-Escolar , Criança , Adolescente , Adulto , Masculino , Feminino , Glomerulonefrite/epidemiologia , Glomerulonefrite/urina , Antiestreptolisina/sangue , Testes de Fixação de Complemento , Etnologia , Hospitalização , Negro ou Afro-Americano , Infecções Estreptocócicas/epidemiologia , Trinidad e TobagoRESUMO
Continued improvement was noted among 722 patients in Trinidad seven to 12 years after the onset of poststreptococcal glomerulonephritis. In the five years since earlier follow-up, two of 709 patients with previous symptomatic disease apparently had died from renal failure, and 10 patients had died from unrelated causes. Nineteen patients presently had proteinuria, three had hematurias, and three had proteinuria plus hematuria. Of these abnormalities, proteinurias in only three patients and proteinuria plus hematuria in three more patients were persistent. Thus, 0.8 per cent of the study group had persistent abnormalities. When one adds those dead with renal disease, the percentage with renal damage becomes 1.1 per cent. In addition, six patients had protein in the two urine samples obtained after assuming the lordotic position for 10 minutes and in only one of the two urine samples obtained upon rising in the morning, making 1.4 per cent with probable evidence of chronic renal disease including the dead patients. Hypertension was present in 16 (2.3 per cent) of the patients and was much more common in those more than 20 years old (18.4 per cent). However, this prevalence of hypertension did not exceed that found in normal Trinidadians. Only three patients had serum creatitine values greater than 1.2 mg/dl. None of 13 patients with previous asymptomatic glomerulonephritis presently showed any abnormality. Thus, very few cases of chronic poststreptococcal glomerulonephritis appear to have developed in the 722 patients studied (AU)
Assuntos
Humanos , Pré-Escolar , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Insuficiência Renal Crônica/etiologia , Glomerulonefrite/epidemiologia , Glomerulonefrite/etiologia , Infecções Estreptocócicas/epidemiologia , Hematúria/etiologia , Hipertensão/etiologia , Proteinúria/etiologia , Seguimentos , Trinidad e TobagoRESUMO
Three patients of the 760 with symptomatic poststreptococcal acute glomerulonephritis in Trinidad who were chosen for follow-up in 1968 or 1970 apparently had not healed initially and consistently had hematuria, usually with proteinuria, in our studies. One of these patients died in renal failure between 1972 and 1976 (six to 10 years after her initial illness). The other two are now 19 and 25 years old, 12 and 15 years after their initial illnesses, with normal blood pressures and serum creatinine values. Another 14 of the 534 patients currently examined had persistent abnormalities: three of these 14 appeared to have had lipoid nephrosis in the beginning, with recurrent proteinria since then; two had urinary-tract infections when examined; one had probably had a third attack of poststreptococcal acute glomerulonephritis; and eight had acquired proteinuria, which may or may not have been related to poststreptococcal acute glomerulonephritis. Thus, our data continue to indicate a good long-term prognosis for most of the patients with this disease in Trinindad.(AU)
Assuntos
Humanos , Criança , Adolescente , Adulto , Pessoa de Meia-Idade , Masculino , Feminino , Glomerulonefrite/epidemiologia , Seguimentos , Proteinúria , Hematúria , Hipertensão , Creatinina/sangue , Grupos Controle , Insuficiência Renal Crônica/mortalidade , Nefrose LipoideRESUMO
Ninety-three patients with acute rheumatic fever and 195 patients with acute glomerulonephritis were observed in Trinidad during an outbreak of scabies with a high incidence of secondary streptococcal infections. Clinical and laboratory manifestations of ARF were the same as those seen in temperate zones, except that antistreptolysin O titers were less markedly increased. The patients with ARF were similar to those with AGN in respect to sex, race, location of residence, and living conditions, but were older and had markedly fewer skin infections. Currently prevalent nephritogenic streptococcal strains never were isolated from patients with ARF even when M55 streptococci appeared and led to an epidemic of AGN.(AU)