Detalhe da pesquisa
1.
HMGB1 mediates invasion and PD-L1 expression through RAGE-PI3K/AKT signaling pathway in MDA-MB-231 breast cancer cells.
BMC Cancer
; 22(1): 578, 2022 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35610613
2.
Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.
Metabolomics
; 16(4): 50, 2020 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32285223
3.
Functional imaging and circulating biomarkers of response to regorafenib in treatment-refractory metastatic colorectal cancer patients in a prospective phase II study.
Gut
; 67(8): 1484-1492, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28790159
4.
Metabolic biomarkers of response to the AKT inhibitor MK-2206 in pre-clinical models of human colorectal and prostate carcinoma.
Br J Cancer
; 119(9): 1118-1128, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30377337
5.
Characterisation of CCT271850, a selective, oral and potent MPS1 inhibitor, used to directly measure in vivo MPS1 inhibition vs therapeutic efficacy.
Br J Cancer
; 116(9): 1166-1176, 2017 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28334731
6.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol
; 11(12): 973-980, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502155
7.
Endothelial Angiogenesis and Barrier Function in Response to Thrombin Require Ca2+ Influx through the Na+/Ca2+ Exchanger.
J Biol Chem
; 290(30): 18412-28, 2015 Jul 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-25979335
8.
Investigating intracranial tumour growth patterns with multiparametric MRI incorporating Gd-DTPA and USPIO-enhanced imaging.
NMR Biomed
; 29(11): 1608-1617, 2016 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-27671990
9.
Synthesis and Evaluation of a 2,11-Cembranoid-Inspired Library.
Chemistry
; 22(16): 5657-64, 2016 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26929153
10.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett
; 26(5): 1443-51, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852363
11.
Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.
Proc Natl Acad Sci U S A
; 109(20): E1267-76, 2012 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22529373
12.
Cancer-associated fibroblasts induce high mobility group box 1 and contribute to resistance to doxorubicin in breast cancer cells.
BMC Cancer
; 14: 955, 2014 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25512109
13.
A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.
J Am Chem Soc
; 135(28): 10418-25, 2013 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23796364
14.
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer.
Breast Cancer Res
; 15(5): R92, 2013 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24286369
15.
Epigenetic disruption of cadherin-11 in human cancer metastasis.
J Pathol
; 228(2): 230-40, 2012 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-22374749
16.
Quantitative chemical proteomics reveals new potential drug targets in head and neck cancer.
Mol Cell Proteomics
; 10(12): M111.011635, 2011 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-21955398
17.
Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation.
BMC Biol
; 10: 29, 2012 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22439642
18.
HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
J Med Chem
; 66(8): 5907-5936, 2023 04 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-37017629
19.
Ca2+ influx through reverse mode Na+/Ca2+ exchange is critical for vascular endothelial growth factor-mediated extracellular signal-regulated kinase (ERK) 1/2 activation and angiogenic functions of human endothelial cells.
J Biol Chem
; 286(44): 37919-37931, 2011 Nov 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-21873429
20.
Angiogenic functions of voltage-gated Na+ Channels in human endothelial cells: modulation of vascular endothelial growth factor (VEGF) signaling.
J Biol Chem
; 286(19): 16846-60, 2011 May 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21385874