Pesquisa | Biblioteca Virtual em Saúde Fiocruz

1.

Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes.

McDonald, Meghan E; Li, Chendi; Bian, Hejiao; Smith, Barbara D; Layne, Matthew D; Farmer, Stephen R.

Cell ; 160(1-2): 105-18, 2015 Jan 15.

Artigo em Inglês | MEDLINE | ID: mdl-25579684

2.

Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies.

Rabhi, Nabil; Farmer, Stephen R.

Genes Dev ; 35(21-22): 1395-1397, 2021 11 01.

Artigo em Inglês | MEDLINE | ID: mdl-34725126

3.

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PparÎ³.

Qiang, Li; Wang, Liheng; Kon, Ning; Zhao, Wenhui; Lee, Sangkyu; Zhang, Yiying; Rosenbaum, Michael; Zhao, Yingming; Gu, Wei; Farmer, Stephen R; Accili, Domenico.

Cell ; 150(3): 620-32, 2012 Aug 03.

Artigo em Inglês | MEDLINE | ID: mdl-22863012

4.

LSD1-a pivotal epigenetic regulator of brown and beige fat differentiation and homeostasis.

Lin, Jean Z; Farmer, Stephen R.

Genes Dev ; 30(16): 1793-5, 2016 08 15.

Artigo em Inglês | MEDLINE | ID: mdl-27601528

5.

Brown fat and skeletal muscle: unlikely cousins?

Farmer, Stephen R.

Cell ; 134(5): 726-7, 2008 Sep 05.

Artigo em Inglês | MEDLINE | ID: mdl-18775306

6.

Boning Up on Irisin.

Farmer, Stephen R.

N Engl J Med ; 380(15): 1480-1482, 2019 04 11.

Artigo em Inglês | MEDLINE | ID: mdl-30970196

7.

CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.

Hu, Alexander J; Li, Wei; Dinh, Calvin; Zhang, Yongzhao; Hu, Jamie K; Daniele, Stefano G; Hou, Xiaoli; Yang, Zixuan; Asara, John M; Hu, Guo-Fu; Farmer, Stephen R; Hu, Miaofen G.

Nat Commun ; 15(1): 1091, 2024 Feb 05.

Artigo em Inglês | MEDLINE | ID: mdl-38316780

8.

Roles for peroxisome proliferator-activated receptor Î³ (PPARÎ³) and PPARÎ³ coactivators 1α and 1ß in regulating response of white and brown adipocytes to hypoxia.

Pino, Elizabeth; Wang, Hong; McDonald, Meghan E; Qiang, Li; Farmer, Stephen R.

J Biol Chem ; 287(22): 18351-8, 2012 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-22493496

9.

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity.

Lotfollahzadeh, Saran; Xia, Chaoshuang; Amraei, Razie; Hua, Ning; Kandror, Konstantin V; Farmer, Stephen R; Wei, Wenyi; Costello, Catherine E; Chitalia, Vipul; Rahimi, Nader.

Mol Metab ; 73: 101744, 2023 07.

Artigo em Inglês | MEDLINE | ID: mdl-37245847

10.

Adrenergic Reprogramming of Preexisting Adipogenic Trajectories Steer Naïve Mural Cells Toward Beige Differentiation.

Desevin, Kathleen; Cortez, Briana N; Lin, Jean Z; Lama, Dechen; Layne, Matthew D; Farmer, Stephen R; Rabhi, Nabil.

bioRxiv ; 2023 Aug 26.

Artigo em Inglês | MEDLINE | ID: mdl-37662295

11.

CDK6 is essential for mesenchymal stem cell proliferation and adipocyte differentiation.

Hu, Alexander J; Li, Wei; Pathak, Apana; Hu, Guo-Fu; Hou, Xiaoli; Farmer, Stephen R; Hu, Miaofen G.

Front Mol Biosci ; 10: 1146047, 2023.

Artigo em Inglês | MEDLINE | ID: mdl-37664186

12.

Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes.

Santos, Kaltinaitis B N H; Knobl, Pamela; Henriques, Felipe; Lopes, Magno A; Franco, Felipe O; Bueno, Luana L; Farmer, Stephen R; Batista, Miguel L.

bioRxiv ; 2023 Sep 18.

Artigo em Inglês | MEDLINE | ID: mdl-37781595

13.

Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status.

Dance, Yoseph W; Obenreder, Mackenzie C; Seibel, Alex J; Meshulam, Tova; Ogony, Joshua W; Lahiri, Nikhil; Pacheco-Spann, Laura; Radisky, Derek C; Layne, Matthew D; Farmer, Stephen R; Nelson, Celeste M; Tien, Joe.

Cell Mol Bioeng ; 16(1): 23-39, 2023 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-36660589

14.

Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors.

Rabhi, Nabil; Desevin, Kathleen; Belkina, Anna C; Tilston-Lunel, Andrew; Varelas, Xaralabos; Layne, Matthew D; Farmer, Stephen R.

Life Sci Alliance ; 5(5)2022 05.

Artigo em Inglês | MEDLINE | ID: mdl-35181634

15.

Transcriptional control of adipocyte formation.

Farmer, Stephen R.

Cell Metab ; 4(4): 263-73, 2006 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17011499

16.

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL.

Chakrabarti, Partha; English, Taylor; Karki, Shakun; Qiang, Li; Tao, Rong; Kim, Juyoun; Luo, Zhijun; Farmer, Stephen R; Kandror, Konstantin V.

J Lipid Res ; 52(9): 1693-701, 2011 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-21743036

17.

Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A.

Wang, Dahai; Rabhi, Nabil; Yet, Shaw-Fang; Farmer, Stephen R; Layne, Matthew D.

Sci Rep ; 11(1): 3948, 2021 02 17.

Artigo em Inglês | MEDLINE | ID: mdl-33597582

18.

Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling.

Batista, Miguel L; Meshulam, Tova; Desevin, Kathleen; Rabhi, Nabil; Farmer, Stephen R.

J Vis Exp ; (167)2021 01 18.

Artigo em Inglês | MEDLINE | ID: mdl-33522508

19.

The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice.

Rabhi, Nabil; Desevin, Kathleen; Cortez, Briana Noel; Hekman, Ryan; Lin, Jean Z; Emili, Andrew; Farmer, Stephen R.

Sci Rep ; 11(1): 20365, 2021 10 13.

Artigo em Inglês | MEDLINE | ID: mdl-34645915

20.

Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes.

Jafari, Naser; Kolla, Manohar; Meshulam, Tova; Shafran, Jordan S; Qiu, Yuhan; Casey, Allison N; Pompa, Isabella R; Ennis, Christina S; Mazzeo, Carla S; Rabhi, Nabil; Farmer, Stephen R; Denis, Gerald V.

Sci Signal ; 14(710): eabj2807, 2021 Nov 23.

Artigo em Inglês | MEDLINE | ID: mdl-34813359

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Myocardin-related transcription factor A regulates conversion of progenitors to beige adipocytes.

Unraveling the complexity of thermogenic remodeling of white fat reveals potential antiobesity therapies.

Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of PparÎ³.

LSD1-a pivotal epigenetic regulator of brown and beige fat differentiation and homeostasis.

Brown fat and skeletal muscle: unlikely cousins?

Boning Up on Irisin.

CDK6 inhibits de novo lipogenesis in white adipose tissues but not in the liver.

Roles for peroxisome proliferator-activated receptor Î³ (PPARÎ³) and PPARÎ³ coactivators 1α and 1ß in regulating response of white and brown adipocytes to hypoxia.

Inactivation of Minar2 in mice hyperactivates mTOR signaling and results in obesity.

Adrenergic Reprogramming of Preexisting Adipogenic Trajectories Steer Naïve Mural Cells Toward Beige Differentiation.

CDK6 is essential for mesenchymal stem cell proliferation and adipocyte differentiation.

Pathological beige remodeling induced by cancer cachexia depends on the disease severity and involves mainly the trans-differentiation of mature white adipocytes.

Adipose Cells Induce Escape from an Engineered Human Breast Microtumor Independently of their Obesity Status.

Obesity-induced senescent macrophages activate a fibrotic transcriptional program in adipocyte progenitors.

Transcriptional control of adipocyte formation.

SIRT1 controls lipolysis in adipocytes via FOXO1-mediated expression of ATGL.

Aortic carboxypeptidase-like protein regulates vascular adventitial progenitor and fibroblast differentiation through myocardin related transcription factor A.

Three-Dimensional Adipocyte Culture as a Model to Study Cachexia-Induced White Adipose Tissue Remodeling.

The cyclin dependent kinase inhibitor Roscovitine prevents diet-induced metabolic disruption in obese mice.

Adipocyte-derived exosomes may promote breast cancer progression in type 2 diabetes.