RESUMO
BACKGROUND: Henoch Schonlein purpura (HSP) is a common vasculitis of small vessels whereas endothelin-1 (ET-1) is usually reported elevated in vasculities and systematic inflammation. The aim of the present study was to investigate whether ET-1 levels are correlated with the clinical presentation and the outcome of HSP. METHODS: The study sample consisted of thirty consecutive patients with HSP. An equal number of healthy patients of similar age and the same gender were served as controls. The patients' age range was 2-12.6 years with a mean +/- SD = 6.3 +/- 3 years. All patients had a physical examination with a renal, and an overall clinical score. Blood and urinary biochemistry, immunology investigation, a skin biopsy and ET-1 measurements in blood and urine samples were made at presentation, 1 month later and 1 year after the appearance of HSP. The controls underwent the same investigation with the exception of skin biopsy. RESULTS: ET-1 levels in plasma and urine did not differ between patients and controls at three distinct time points. Furthermore the ET-1 were not correlated with the clinical score and renal involvement was independent from the ET-1 measurements. However, the urinary ET-1 levels were a significant predictor of the duration of the acute phase of HSP (HR = 0.98, p = 0.032, CI0.96-0.99). The ET-1 levels did not correlate with the duration of renal involvement. CONCLUSION: Urinary ET-1 levels are a useful marker for the duration of the acute phase of HSP but not for the length of renal involvement.
Assuntos
Biomarcadores/análise , Endotelina-1/análise , Vasculite por IgA/patologia , Biomarcadores/sangue , Biomarcadores/urina , Biópsia , Contagem de Células Sanguíneas , Estudos de Casos e Controles , Criança , Pré-Escolar , Endotelina-1/sangue , Endotelina-1/urina , Feminino , Humanos , Vasculite por IgA/sangue , Vasculite por IgA/urina , Rim/fisiopatologia , Testes de Função Renal , Modelos Logísticos , Masculino , Valor Preditivo dos Testes , Radioimunoensaio , Pele/patologiaRESUMO
Coeliac disease is a genetic, immunologically mediated small bowel enteropathy that causes malabsorption. The immune inflammatory response to gluten frequently causes damage to many other tissues of the body. We report the association of coeliac disease and alopecia areata in two children, a 13-year-old girl and a 29-month-old girl. Both of our patients had immunoglobulin A (IgA) class endomysial antibodies, IgA and immunoglobulin G (IgG) antigliadin antibodies and subtotal villous atrophy on jejunal biopsy. Administration of a gluten-free diet to our patients resulted in complete hair growth and improved the gastrointestinal symptoms.
Assuntos
Alopecia em Áreas/complicações , Alopecia em Áreas/dietoterapia , Autoanticorpos/análise , Doença Celíaca/complicações , Doença Celíaca/dietoterapia , Glutens/efeitos adversos , Adolescente , Alopecia em Áreas/imunologia , Doenças Autoimunes/diagnóstico , Doença Celíaca/imunologia , Pré-Escolar , Feminino , Seguimentos , Grécia , Humanos , Imunoglobulina A/análise , Imunoglobulina G/análise , Medição de Risco , Resultado do TratamentoRESUMO
Henoch-Schonlein purpura (HSP) is an acute systemic form of vasculitis that has been associated with a number of viral and bacterial infections. Described here are the cases of two children with invasive meningococcal disease who presented with clinical and laboratory findings typical of HSP. Meningococcal infection may have been the trigger for the manifestation of HSP in these patients.