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1.
Osteoarthritis Cartilage ; 19(2): 155-62, 2011 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-20951814

RESUMO

OBJECTIVES: There is an increasing movement to collect and report patient reported outcome measures (PROM's) following total hip replacement (THR). In the UK, the procedure specific PROM of choice is the Oxford Hip Score (OHS). It is currently unclear how to use this information to determine outcome following surgery. The aim of this study was to define a threshold for the OHS that is correlated with patient satisfaction. DESIGN: Prospective cohort study. SETTING: A district general hospital (St. Helier Hospital, Carshalton, UK). PARTICIPANTS: 799 patients receiving THR from 1995 to 2004. MAIN OUTCOME MEASURES: At 12 and 24 months after surgery patients were asked if they were satisfied with surgery and completed the OHS. Receiver operating characteristic (ROC) analyses were used to identify thresholds of follow-up OHS, which best discriminated patient satisfaction. Analyses were stratified by age, sex, body mass index (BMI), baseline OHS and patient expectations. RESULTS: 91.9% of patients were satisfied with THR at 12 months (92.8% at 24 months). Using the ROC technique, the OHS at 12 months associated with patient satisfaction was 38 and at 24 months 33. The OHS at 24 months associated with satisfaction was higher in those with highest tertile of baseline OHS (30, 33, 43 respectively), and lowest tertile of BMI. CONCLUSIONS: We have identified a value of the OHS that predicts patient satisfaction 12-24 months following THR within a standard clinical setting. However, this threshold is markedly influenced by pre-operative OHS and should be stratified accordingly.


Assuntos
Artroplastia de Quadril , Avaliação de Resultados em Cuidados de Saúde , Satisfação do Paciente , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Sensibilidade e Especificidade , Inquéritos e Questionários/normas
2.
Knee ; 27(4): 1212-1218, 2020 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-32711884

RESUMO

BACKGROUND: The aim was to assess the whether there was a clinically important change in the Oxford knee score (OKS) between one and two years after total knee arthroplasty (TKA), and to identify predictors associated with a clinically important change. METHODS: A retrospective cohort study was undertaken using an established arthroplasty database of 5857 primary TKA. Patient demographics, body mass index, social deprivation, OKS and EuroQoL five-domain (EQ-5D) score were collected preoperatively and at one and two years postoperatively. A clinically important change in the OKS was defined as ≥5 points. RESULTS: There was a 0.2 point increase in the OKS between one and two years, which was statistically significant (95% confidence interval (CI) 0.1 to 0.4, p < .0001), but not clinically important. A better preoperative OKS (p < .001) and in contrast a worse one year OKS (p < .001) were independently associated with a greater improvement from one to two years. There were 1006 (17.3%) patients that had a clinically important improvement in the OKS between one and two years. Receiver operating characteristic curve analysis showed that a one year OKS of less than 35 was a reliable predictor of a clinically important improvement between one and two years (area under the curve 0.77, 95% CI 0.76 to 0.78, p < .001). CONCLUSION: There was not a clinically important change in the OKS from one to two years after TKA when assessed as a group. However, individual patients with a one year OKS of less than 35 may demonstrate a clinically important improvement at two years. LEVEL OF EVIDENCE: Retrospective diagnostic study, Level III.


Assuntos
Artroplastia do Joelho/métodos , Benchmarking , Osteoartrite do Joelho/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Osteoartrite do Joelho/diagnóstico , Período Pós-Operatório , Curva ROC , Estudos Retrospectivos , Fatores de Tempo , Resultado do Tratamento
3.
Knee Surg Sports Traumatol Arthrosc ; 17(8): 927-34, 2009 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19333579

RESUMO

The performance of total knee arthroplasty in deeply flexed postures is of increasing concern as the procedure is performed on younger, more physically active and more culturally diverse populations. Several implant design factors, including tibiofemoral conformity, tibial slope and posterior condylar geometry have been shown directly to affect deep flexion performance. The goal of this study was to evaluate the kinematics of a fixed-bearing, asymmetric, medial rotation arthroplasty design in moderate and deep flexion. Thirteen study participants (15 knees) with a medial rotation knee arthroplasty were observed performing a weight-bearing lunge activity to maximum comfortable flexion and kneeling on a padded bench from 90 degrees to maximum comfortable flexion using lateral fluoroscopy. Subjects averaged 74 years of age and nine were female. At maximum weight-bearing flexion, the knees exhibited 115 degrees of implant flexion (102 degrees-125 degrees) and 7 degrees (-3 degrees to 12 degrees) of tibial internal rotation. The medial and lateral condylar translated posteriorly by 2 and 5 mm, respectively. At maximum kneeling flexion, the knees exhibited 119 degrees of implant flexion (101 degrees-139 degrees ) and 5 degrees (-2 degrees to 14 degrees) of tibial internal rotation. The lateral condyle translated posteriorly by 11 mm. The medial rotation knee exhibited motion patterns similar to those observed in the normal knee, but less tibial rotation. The medially conforming articulation beneficially controls femoral AP position in deep flexion, in patients who require such motion as part of their lifestyle.


Assuntos
Artroplastia do Joelho , Articulação do Joelho/fisiologia , Prótese do Joelho , Movimento/fisiologia , Suporte de Carga/fisiologia , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Feminino , Fluoroscopia , Humanos , Articulação do Joelho/diagnóstico por imagem , Masculino , Teste de Materiais , Pessoa de Meia-Idade , Desenho de Prótese , Amplitude de Movimento Articular/fisiologia , Rotação
4.
Proc Inst Mech Eng H ; 223(1): 27-44, 2009 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-19239065

RESUMO

After the first early failures, proximal femoral epiphyseal replacement is becoming popular again. Prosthesis-to-bone load transfer is critical for two reasons: stress shielding is suspected of being responsible for a number of failures of early epiphyseal prostheses; stress concentration is probably responsible of the relevant number of early femoral neck fractures in resurfaced patients. The scope of this work was to experimentally investigate the load transfer of a commercial epiphyseal prosthesis (Birmingham Hip Replacement (BHR)) and an innovative prototype proximal epiphyseal replacement. To investigate bone surface strain, ten cadaveric femurs were instrumented with 15 triaxial strain gauges. In addition the cement layer of the prototype was instrumented with embedded gauges to estimate the strain in the adjacent trabecular bone. Six different loading configurations were investigated, with and without muscles. For the BHR prosthesis, significant stress shielding was observed on the posterior side of the head-neck region (the strain was halved); a pronounced stress concentration was observed on the anterior surface (up to five times in some specimens); BHR was quite sensitive to the different loading configurations. For the prototype, the largest stress shielding was observed in the neck region (lower than the BHR; alteration less than 20 per cent); some stress concentration was observed at the head region, close to the rim of the prosthesis (alteration less than 20 per cent); the different loading configurations had similar effects. Such large alterations with respect to the pre-operative conditions were found only in regions where the strain level was low. Conversely, alterations were moderate where the strain was higher. Thus, prosthesis-to-bone load transfer of both devices has been elucidated; the prototype preserved a stress distribution closer to the physiological condition.


Assuntos
Análise de Falha de Equipamento , Cabeça do Fêmur/fisiopatologia , Cabeça do Fêmur/cirurgia , Lâmina de Crescimento/fisiopatologia , Lâmina de Crescimento/cirurgia , Prótese de Quadril , Modelos Biológicos , Simulação por Computador , Módulo de Elasticidade , Humanos , Desenho de Prótese , Estresse Mecânico
5.
Bone Joint Res ; 8(5): 207-215, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-31214333

RESUMO

OBJECTIVES: The medially spherical GMK Sphere (Medacta International AG, Castel San Pietro, Switzerland) total knee arthroplasty (TKA) was previously shown to accommodate lateral rollback while pivoting around a stable medial compartment, aiming to replicate native knee kinematics in which some coronal laxity, especially laterally, is also present. We assess coronal plane kinematics of the GMK Sphere and explore the occurrence and pattern of articular separation during static and dynamic activities. METHODS: Using pulsed fluoroscopy and image matching, the coronal kinematics and articular surface separation of 16 well-functioning TKAs were studied during weight-bearing and non-weight-bearing, static, and dynamic activities. The closest distances between the modelled articular surfaces were examined with respect to knee position, and proportions of joint poses exhibiting separation were computed. RESULTS: Overall, 1717 joint poses were analyzed. At a 1.0 mm detection threshold, 37 instances of surface separation were observed in the lateral compartment and four medially (p < 0.001). Separation was activity-dependent, both laterally and medially (p < 0.001), occurring more commonly during static deep flexion in the lateral compartment, and during static rotation in the medial compartment. Lateral separation occurred more frequently than medial during kneeling (7/14 lateral vs 1/14 medial; p = 0.031) and stepping (20/1022 lateral vs 0/1022 medial; p < 0.001). Separation varied significantly between individuals during dynamic activities. CONCLUSION: No consistent association between closest distances of the articular surfaces and knee position was found during any activity. Lift-off was infrequent and depended on the activity performed and the individual knee. Lateral separation was consistent with the design rationale. Medial lift-off was rare and mostly in non-weight-bearing activities.Cite this article: S. Key, G. Scott, J.G. Stammers, M. A. R. Freeman†, V. Pinskerova, R. E. Field, J. Skinner, S. A. Banks. Does lateral lift-off occur in static and dynamic activity in a medially spherical total knee arthroplasty? A pulsed-fluoroscopic investigation. Bone Joint Res 2019;8:207-215. DOI: 10.1302/2046-3758.85.BJR-2018-0237.R1.

6.
J Bone Joint Surg Br ; 90(3): 360-3, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18310761

RESUMO

We audited the relationship between obesity and the age at which hip and knee replacement was undertaken at our centre. The database was analysed for age, the Oxford hip or knee score and the body mass index (BMI) at the time of surgery. In total, 1369 patients were studied, 1025 treated by hip replacement and 344 by knee replacement. The patients were divided into five groups based on their BMI (normal, overweight, moderately obese, severely obese and morbidly obese). The difference in the mean Oxford score at surgery was not statistically significant between the groups (p > 0.05). For those undergoing hip replacement, the mean age of the morbidly obese patients was ten years less than that of those with a normal BMI. For those treated by knee replacement, the difference was 13 years. The age at surgery fell significantly for those with a BMI > 35 kg/m(2) for both hip and knee replacement (p > 0.05). This association was stronger for patients treated by knee than by hip replacement.


Assuntos
Artroplastia de Quadril , Artroplastia do Joelho , Obesidade/complicações , Obesidade/cirurgia , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Bases de Dados Factuais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Obesidade Mórbida/complicações , Obesidade Mórbida/cirurgia , Osteoartrite do Quadril/complicações , Osteoartrite do Quadril/cirurgia , Osteoartrite do Joelho/complicações , Osteoartrite do Joelho/cirurgia , Sobrepeso/complicações , Sobrepeso/cirurgia , Estudos Retrospectivos , Fatores Sexuais
7.
J Bone Joint Surg Br ; 90(3): 319-23, 2008 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-18310753

RESUMO

Hip resurfacing is a bone-conserving procedure with respect to proximal femoral resection, but there is debate in the literature as to whether the same holds true for the acetabulum. We have investigated whether the Birmingham hip resurfacing conserves acetabular bone. Between 1998 and 2005, 500 Birmingham hip resurfacings were performed by two surgeons. Between 1996 and 2005 they undertook 700 primary hip replacements, with an uncemented acetabular component. These patients formed the clinical material to compare acetabular component sizing. The Birmingham hip resurfacing group comprised 350 hips in men and 150 hips in women. The uncemented total hip replacement group comprised 236 hips in men and 464 hips in women. Age- and gender-matched analysis of a cohort of patients for the sizes of the acetabular components required for the two types of replacement was also undertaken. Additionally, an analysis of the sizes of the components used by each surgeon was performed. For age-matched women, the mean outside diameter of the Birmingham hip resurfacing acetabular components was 2.03 mm less than that of the acetabular components in the uncemented total hip replacements (p < 0.0001). In similarly matched men there was no significant difference (p = 0.77). A significant difference was also found between the size of acetabular components used by the two surgeons for Birmingham hip resurfacing for both men (p = 0.0015) and women (p = 0.001). In contrast, no significant difference was found between the size of acetabular components used by the two surgeons for uncemented total hip replacement in either men or women (p = 0.06 and p = 0.14, respectively). This suggests that variations in acetabular preparation also influence acetabular component size in hip resurfacing.


Assuntos
Acetábulo/patologia , Artroplastia de Quadril/métodos , Padrões de Prática Médica , Adulto , Idoso , Idoso de 80 Anos ou mais , Análise de Variância , Cimentos Ósseos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Ortopedia , Estudos Retrospectivos , Fatores Sexuais , Resultado do Tratamento
8.
J Bone Joint Surg Br ; 88(3): 315-20, 2006 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-16498003

RESUMO

We describe the results at five years of a prospective study of a new tri-tapered polished, cannulated, cemented femoral stem implanted in 51 patients (54 hips) with osteoarthritis. The mean age and body mass index of the patients was 74 years and 27.9, respectively. Using the anterolateral approach, half of the stems were implanted by a consultant orthopaedic surgeon and half by six different registrars. There were three withdrawals from the study because of psychiatric illness, a deep infection and a recurrent dislocation. Five deaths occurred prior to five-year follow-up and one patient withdrew from clinical review. In the remaining 51 hips the mean pre-operative Oxford hip score was 47 points which decreased to 19 points at five years (45 hips). Of the stems 49 (98%) were implanted within 1 degrees of neutral in the femoral canal. The mean migration of the stem at five years was 1.9 mm and the survivorship for aseptic loosening was 100%. There was no significant difference in outcome between the consultant and registrar groups. At five years, the results were comparable with those of other polished, tapered, cemented stems. Long-term surveillance continues.


Assuntos
Artroplastia de Quadril/instrumentação , Fêmur/cirurgia , Prótese de Quadril , Osteoartrite do Quadril/cirurgia , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril/métodos , Materiais Biocompatíveis , Fêmur/diagnóstico por imagem , Articulação do Quadril/diagnóstico por imagem , Prótese de Quadril/efeitos adversos , Humanos , Osteoartrite do Quadril/diagnóstico por imagem , Projetos Piloto , Complicações Pós-Operatórias/etiologia , Estudos Prospectivos , Desenho de Prótese , Radiografia , Resultado do Tratamento
9.
J Bone Joint Surg Br ; 88(8): 1110-5, 2006 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-16877617

RESUMO

The effects of the method of fixation and interface conditions on the biomechanics of the femoral component of the Birmingham hip resurfacing arthroplasty were examined using a highly detailed three-dimensional computer model of the hip. Stresses and strains in the proximal femur were compared for the natural femur and for the femur resurfaced with the Birmingham hip resurfacing. A comparison of cemented versus uncemented fixation showed no advantage of either with regard to bone loading. When the Birmingham hip resurfacing femoral component was fixed to bone, proximal femoral stresses and strains were non-physiological. Bone resorption was predicted in the inferomedial and superolateral bone within the Birmingham hip resurfacing shell. Resorption was limited to the superolateral region when the stem was not fixed. The increased bone strain observed adjacent to the distal stem should stimulate an increase in bone density at that location. The remodelling of bone seen during revision of failed Birmingham hip resurfacing implants appears to be consistent with the predictions of our finite element analysis.


Assuntos
Artroplastia de Quadril , Fêmur/cirurgia , Articulação do Quadril/fisiopatologia , Artroplastia de Quadril/métodos , Fenômenos Biomecânicos , Densidade Óssea/fisiologia , Reabsorção Óssea/fisiopatologia , Cadáver , Cimentação , Feminino , Análise de Elementos Finitos , Articulação do Quadril/cirurgia , Prótese de Quadril , Humanos , Pessoa de Meia-Idade , Modelos Biológicos , Estresse Mecânico
10.
Bone Joint Res ; 5(3): 80-6, 2016 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-26965166

RESUMO

OBJECTIVES: Throughout the 20th Century, it has been postulated that the knee moves on the basis of a four-bar link mechanism composed of the cruciate ligaments, the femur and the tibia. As a consequence, the femur has been thought to roll back with flexion, and total knee arthroplasty (TKA) prostheses have been designed on this basis. Recent work, however, has proposed that at a position of between 0° and 120° the medial femoral condyle does not move anteroposteriorly whereas the lateral femoral condyle tends, but is not obliged, to roll back - a combination of movements which equates to tibial internal/ femoral external rotation with flexion. The aim of this paper was to assess if the articular geometry of the GMK Sphere TKA could recreate the natural knee movements in situ/in vivo. METHODS: The pattern of knee movement was studied in 15 patients (six male: nine female; one male with bilateral TKAs) with 16 GMK Sphere implants, at a mean age of 66 years (53 to 76) with a mean BMI of 30 kg/m(2) (20 to 35). The motions of all 16 knees were observed using pulsed fluoroscopy during a number of weight-bearing and non-weight-bearing static and dynamic activities. RESULTS: During maximally flexed kneeling and lunging activities, the mean tibial internal rotation was 8° (standard deviation (sd) 6). At a mean 112° flexion (sd 16) during lunging, the medial and lateral condyles were a mean of 2 mm (sd 3) and 8 mm (sd 4) posterior to a transverse line passing through the centre of the medial tibial concavity. With a mean flexion of 117° (sd 14) during kneeling, the medial and lateral condyles were a mean of 1 mm (sd 4) anterior and 6 mm (sd 4) posterior to the same line. During dynamic stair and pivoting activities, there was a mean anteroposterior translation of 0 mm to 2 mm of the medial femoral condyle. Backward lateral condylar translation occurred and was linearly related to tibial rotation. CONCLUSION: The GMK Sphere TKA in our study group shows movements similar in pattern, although reduced in magnitude, to those in recent reports relating to normal knees during several activities. Specifically, little or no translation of the medial femoral condyle was observed during flexion, but there was posterior roll-back of the lateral femoral condyle, equating to tibiofemoral rotation. We conclude that the GMK Sphere is anteroposteriorly stable medially and permits rotation about the medial compartment.Cite this article: Professor G. Scott. Can a total knee arthroplasty be both rotationally unconstrained and anteroposteriorly stabilised?: A pulsed fluoroscopic investigation. Bone Joint Res 2016;5:80-86. DOI: 10.1302/2046-3758.53.2000621.

11.
J Bone Joint Surg Br ; 87(10): 1344-51, 2005 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-16189305

RESUMO

The Cambridge Cup has been designed to replace the horseshoe-shaped articular cartilage of the acetabulum and the underlying subchondral bone. It is intended to provide physiological loading with minimal resection of healthy bone. The cup has been used in 50 women with displaced, subcapital fractures of the neck of the femur. In 24 cases, the cup was coated with hydroxyapatite. In 26, the coating was removed before implantation in order to simulate the effect of long-term resorption. The mean Barthel index and the Charnley-modified Merle d'Aubigné scores recovered to their levels before fracture. We reviewed 30 women at two years, 21 were asymptomatic and nine reported minimal pain. The mean scores deteriorated slightly after five years reflecting the comorbidity of advancing age. Patients with the hydroxyapatite-coated components remained asymptomatic, with no wear or loosening. The uncoated components migrated after four years and three required revision. This trial shows good early results using a novel, hydroxyapatite-coated, physiological acetabular component.


Assuntos
Fraturas do Colo Femoral/cirurgia , Prótese de Quadril , Acetábulo/fisiopatologia , Acetábulo/cirurgia , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril/métodos , Densidade Óssea , Materiais Revestidos Biocompatíveis , Durapatita , Feminino , Seguimentos , Humanos , Desenho de Prótese , Reoperação
12.
J Bone Joint Surg Br ; 87(5): 618-22, 2005 May.
Artigo em Inglês | MEDLINE | ID: mdl-15855360

RESUMO

We have used the Oxford hip score to monitor the progress of 1908 primary and 279 revision hip replacements undertaken since the start of 1995. Our review programme began in early 1999 and has generated 3900 assessments. The mean pre-operative scores for primary and revision cases were 40.95 and 40.11, respectively. The mean annual score for primary replacement at between 12 and 84 months ranged between 20.60 and 22.57. A comparison of cross-sectional and longitudinal data showed no significant differences. All post-operative reviews showed a significant improvement (p < or = 0.0001). The 50- to 60-year-old group scored significantly better than the patients over 80 years of age up to 48 months (p < 0.01). A subgroup of 826 National Health Service (NHS) and 397 private patients, treated by the senior author (2292 Oxford assessments), had a higher (i.e. worse) mean pre-operative score for the NHS patients (p < or = 0.001). The private patients scored better than the NHS group up to 84 months (p < 0.05). Patients treated by a surgeon performing more than 100 replacements each year had a significantly better outcome up to five years than those operated on by surgeons performing fewer than 20 replacements each year. The age of the patients at the time of operation, and their pre-operative level of disability, have both been identified as affecting the long-term outcome. Awareness of the influence of these factors should assist surgeons to provide balanced advice.


Assuntos
Artroplastia de Quadril/métodos , Articulação do Quadril/cirurgia , Idoso , Idoso de 80 Anos ou mais , Índice de Massa Corporal , Estudos Transversais , Avaliação da Deficiência , Feminino , Articulação do Quadril/fisiopatologia , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Cuidados Pré-Operatórios/métodos , Prática Privada , Reoperação , Índice de Gravidade de Doença , Fatores Sexuais , Medicina Estatal , Resultado do Tratamento
13.
J Bone Joint Surg Br ; 77(1): 110-3, 1995 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-7822365

RESUMO

Since 1987, 22 children with myelomeningocele have been fitted with reciprocating orthoses. The level of the spinal lesions ranged from T10 to L4 and 13 had associated spinal deformities. Twelve of the patients currently use a Reciprocating Gait Orthosis, seven use a Hip Guidance Orthosis or Parawalker, one has progressed to a Knee Ankle Foot Orthosis, one has died and one has been lost to follow-up. The reciprocating orthoses are worn for a mean of 3.5 hours per day (1 to 6.5); daily usage by girls is almost twice that by boys. The mean daily usage by community walkers is 4.2 hours (13 children) as against 2.8 hours by household ambulators (8 children). Active hip flexion is not essential and fixed-flexion contractures up to 35 degrees can be accommodated. The average breakdown rate is 0.45 per year with an average of 1.5 adjustments each year. The average annual cost of a reciprocating orthosis is Aus$750 (375 pounds, US$570); this includes fabrication, adjustments and repairs.


Assuntos
Meningomielocele/reabilitação , Aparelhos Ortopédicos , Adolescente , Criança , Pré-Escolar , Falha de Equipamento , Feminino , Humanos , Lactente , Masculino , Aparelhos Ortopédicos/economia
14.
J Bone Joint Surg Br ; 76(6): 975-81, 1994 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-7983131

RESUMO

Between 1980 and 1988, displacement bone-marrow transplantation was performed on 25 children with Hurler's syndrome (type-1 mucopolysaccharidosis). We describe the musculoskeletal development of 11 of the 12 surviving children and the orthopaedic procedures undertaken to treat progressive thoracolumbar kyphosis, hip subluxation and carpal tunnel syndrome. We found abnormal bone modelling, focal failures of ossification and an avascular disorder of the femoral head in every patient and offer an explanation for these phenomena. Increasing valgus deformity of the knees and progressive generalised myopathy caused loss of mobility as the children entered adolescence. The benefit of bone-marrow transplantation as a treatment for the skeletal disorders of Hurler's syndrome is limited by the poor penetration of the musculoskeletal tissues by the enzyme derived from the leucocytes.


Assuntos
Transplante de Medula Óssea , Mucopolissacaridose I/terapia , Doenças Musculoesqueléticas/cirurgia , Síndrome do Túnel Carpal/diagnóstico por imagem , Síndrome do Túnel Carpal/etiologia , Síndrome do Túnel Carpal/cirurgia , Criança , Pré-Escolar , Necrose da Cabeça do Fêmur/diagnóstico por imagem , Necrose da Cabeça do Fêmur/etiologia , Necrose da Cabeça do Fêmur/cirurgia , Luxação do Quadril/diagnóstico por imagem , Luxação do Quadril/etiologia , Luxação do Quadril/cirurgia , Humanos , Lactente , Deformidades Articulares Adquiridas/diagnóstico por imagem , Deformidades Articulares Adquiridas/etiologia , Deformidades Articulares Adquiridas/cirurgia , Articulação do Joelho/diagnóstico por imagem , Articulação do Joelho/cirurgia , Cifose/diagnóstico por imagem , Cifose/etiologia , Cifose/cirurgia , Mucopolissacaridose I/complicações , Doenças Musculoesqueléticas/diagnóstico por imagem , Doenças Musculoesqueléticas/etiologia , Ossificação Heterotópica/diagnóstico por imagem , Ossificação Heterotópica/etiologia , Ossificação Heterotópica/cirurgia , Radiografia
15.
Int Surg ; 65(4): 359-62, 1980.
Artigo em Inglês | MEDLINE | ID: mdl-6262268

RESUMO

A 52-year-old female had radical surgery on both breasts in 1971 and 1973 for infiltrating lobular carcinoma of the breast. One year later, multiple metastases simulating Crohn's disease were found radiologically and intraoperatively in the colon and small bowel. The pathological examination revealed multiple areas of linitis plastica type carcinoma in the colon and small bowel. Review of the breast slides showed that the original breast carcinoma was morphologically identical to the metastatic lesions. The literature is reviewed and arguments are presented to attest that signet-ring-cell carcinoma of the breast is a distinct entity, which not too infrequently metastasizes to the gastrointestinal tract.


Assuntos
Adenocarcinoma Mucinoso , Adenocarcinoma/diagnóstico , Neoplasias da Mama , Neoplasias do Colo/diagnóstico , Neoplasias do Íleo/diagnóstico , Adenocarcinoma/secundário , Colite/diagnóstico , Neoplasias do Colo/secundário , Doença de Crohn/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Neoplasias do Íleo/secundário , Ileíte/diagnóstico , Pessoa de Meia-Idade
16.
Bone Joint J ; 95-B(1): 38-44, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23307671

RESUMO

We present a comparison of patient-reported outcomes (PROMs) in relation to patient age, in patients who had received a total (TKR) or unicompartmental knee replacement (UKR). The outcome was evaluated using the Oxford knee score (OKS), EuroQol (EQ-5D) and satisfaction scores. Patients aged 65 to 84 years demonstrated better pre-operative function scores than those aged < 65 years (OKS, p = 0.03; EQ-5D, p = 0.048) and those aged ≥ 85 years (OKS, p = 0.03). Post-operative scores were comparable across age groups, but a linear trend for greater post-operative improvement in OKS and EQ-5D was seen with decreasing age (p < 0.033). The overall mean satisfaction score at six months was 84.9, but those aged < 55 years exhibited a lower mean level of satisfaction (78.3) compared with all other age groups (all p < 0.031). The cumulative overall two-year revision rate was 1.3%. This study demonstrates that good early outcomes, as measured by the OKS and EQ-5D, can be anticipated following knee replacement regardless of the patient's age, although younger patients gain greater improvement. However, the lower satisfaction in those aged < 55 years is a concern, and suggests that outcome is not fully encapsulated by the OKS and EQ-5D evaluation, and raises the question whether the OKS alone is an appropriate measure of pain and function in younger, more active individuals.


Assuntos
Artroplastia do Joelho , Indicadores Básicos de Saúde , Osteoartrite do Joelho/cirurgia , Satisfação do Paciente/estatística & dados numéricos , Inquéritos e Questionários , Adulto , Fatores Etários , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Modelos Lineares , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Reoperação/estatística & dados numéricos , Resultado do Tratamento
17.
Bone Joint J ; 95-B(1): 45-51, 2013 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-23307672

RESUMO

The Oxford knee score (OKS) is a validated and widely accepted disease-specific patient-reported outcome measure, but there is limited evidence regarding any long-term trends in the score. We reviewed 5600 individual OKS questionnaires (1547 patients) from a prospectively-collected knee replacement database, to determine the trends in OKS over a ten-year period following total knee replacement. The mean OKS pre-operatively was 19.5 (95% confidence interval (CI) 18.8 to 20.2). The maximum post-operative OKS was observed at two years (mean score 34.4 (95% CI 33.7 to 35.2)), following which a gradual but significant decline was observed through to the ten-year assessment (mean score 30.1 (95% CI 29.1 to 31.1)) (p < 0.001). A similar trend was observed for most of the individual OKS components (p < 0.001). Kneeling ability initially improved in the first year but was then followed by rapid deterioration (p < 0.001). Pain severity exhibited the greatest improvement, although residual pain was reported in over two-thirds of patients post-operatively, and peak improvement in the night pain component did not occur until year four. Post-operative OKS was lower for women (p < 0.001), those aged < 60 years (p < 0.003) and those with a body mass index > 35 kg/m(2) (p < 0.014), although similar changes in scores were observed. This information may assist surgeons in advising patients of their expected outcomes, as well as providing a comparative benchmark for evaluating longer-term outcomes following knee replacement.


Assuntos
Artroplastia do Joelho , Indicadores Básicos de Saúde , Osteoartrite do Joelho/cirurgia , Inquéritos e Questionários , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Seguimentos , Humanos , Funções Verossimilhança , Masculino , Pessoa de Meia-Idade , Modelos Estatísticos , Medição da Dor , Resultado do Tratamento
18.
J Bone Joint Surg Br ; 94(3): 412-8, 2012 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-22371552

RESUMO

We obtained information from the Elective Orthopaedic Centre on 1523 patients with baseline and six-month Oxford hip scores (OHS) after undergoing primary hip replacement (THR) and 1784 patients with Oxford knee scores (OKS) for primary knee replacement (TKR) who completed a six-month satisfaction questionnaire. Receiver operating characteristic curves identified an absolute change in OHS of 14 points or more as the point that discriminates best between patients' satisfaction levels and an 11-point change for the OKS. Satisfaction is highest (97.6%) in patients with an absolute change in OHS of 14 points or more, compared with lower levels of satisfaction (81.8%) below this threshold. Similarly, an 11-point absolute change in OKS was associated with 95.4% satisfaction compared with 76.5% below this threshold. For the six-month OHS a score of 35 points or more distinguished patients with the highest satisfaction level, and for the six-month OKS 30 points or more identified the highest level of satisfaction. The thresholds varied according to patients' pre-operative score, where those with severe pre-operative pain/function required a lower six-month score to achieve the highest levels of satisfaction. Our data suggest that the choice of a six-month follow-up to assess patient-reported outcomes of THR/TKR is acceptable. The thresholds help to differentiate between patients with different levels of satisfaction, but external validation will be required prior to general implementation in clinical practice.


Assuntos
Artroplastia de Quadril/normas , Artroplastia do Joelho/normas , Indicadores Básicos de Saúde , Satisfação do Paciente , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril/reabilitação , Artroplastia do Joelho/reabilitação , Métodos Epidemiológicos , Feminino , Humanos , Londres , Masculino , Pessoa de Meia-Idade , Psicometria , Resultado do Tratamento , Adulto Jovem
19.
J Bone Joint Surg Br ; 94(8): 1120-5, 2012 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-22844056

RESUMO

Using general practitioner records and hospital notes and through direct telephone conversation with patients, we investigated the accuracy of nine patient-reported complications gathered from a self-completed questionnaire after elective joint replacement surgery of the hip and knee. A total of 402 post-discharge complications were reported after 8546 elective operations that were undertaken within a three-year period. These were reported by 136 men and 240 women with a mean age of 71.8 years (34 to 93). A total of 319 reported complications (79.4%; 95% confidence interval 75.4 to 83.3) were confirmed to be correct. High rates of correct reporting were demonstrated for infection (94.5%) and the need for further surgery (100%), whereas the rates of reporting deep-vein thrombosis (DVT), pulmonary embolism, myocardial infarction and stroke were lower (75% to 84.2%). Dislocation, peri-prosthetic fractures and nerve palsy had modest rates of correct reporting (36% to 57.1%). More patients who had knee surgery delivered incorrect reports of dislocation (p = 0.001) and DVT (p = 0.013). Despite these variations, it appears that post-operative complications may form part of a larger patient-reported outcome programme after elective joint replacement surgery.


Assuntos
Artroplastia de Quadril/efeitos adversos , Artroplastia do Joelho/efeitos adversos , Autorrelato/normas , Adulto , Idoso , Idoso de 80 Anos ou mais , Artroplastia de Quadril/métodos , Artroplastia do Joelho/métodos , Inglaterra/epidemiologia , Feminino , Luxação do Quadril/epidemiologia , Luxação do Quadril/etiologia , Humanos , Luxação do Joelho/epidemiologia , Luxação do Joelho/etiologia , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/epidemiologia , Infarto do Miocárdio/etiologia , Satisfação do Paciente , Infecções Relacionadas à Prótese/epidemiologia , Infecções Relacionadas à Prótese/cirurgia , Embolia Pulmonar/epidemiologia , Embolia Pulmonar/etiologia , Reoperação/métodos , Reoperação/estatística & dados numéricos , Acidente Vascular Cerebral/epidemiologia , Acidente Vascular Cerebral/etiologia , Resultado do Tratamento , Trombose Venosa/epidemiologia , Trombose Venosa/etiologia
20.
J Bone Joint Surg Br ; 93(1): 108-10, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21196553

RESUMO

Developmental dysplasia of the hip predisposes to premature degenerative hip disease. A number of operations have been described to improve acetabular cover and have achieved varying degrees of success. We present the case of an 84-year-old woman, who underwent a shelf procedure to reconstruct a dysplastic hip 75 years ago. To date, the shelf remains intact and the hip is asymptomatic. We believe this represents the longest documented outcome of any procedure to stabilise the hip.


Assuntos
Acetábulo/cirurgia , Luxação Congênita de Quadril/cirurgia , Osteotomia/métodos , Idoso de 80 Anos ou mais , Artroplastia de Quadril , Feminino , Seguimentos , Humanos , Osteoartrite do Quadril/diagnóstico por imagem , Osteoartrite do Quadril/cirurgia , Radiografia , Reoperação , Fatores de Tempo
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