Detalhe da pesquisa
1.
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Nat Chem Biol
; 17(10): 1084-1092, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34294896
2.
Structure of the human myostatin precursor and determinants of growth factor latency.
EMBO J
; 37(3): 367-383, 2018 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29330193
3.
Carbonate fluxes by coccolithophore species between NW Africa and the Caribbean: Implications for the biological carbon pump.
Limnol Oceanogr
; 66(8): 3190-3208, 2021 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-34588708
4.
Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset.
Proc Natl Acad Sci U S A
; 115(31): E7293-E7302, 2018 07 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-30012610
5.
Balancing Specificity and Promiscuity in Enzyme Evolution: Multidimensional Activity Transitions in the Alkaline Phosphatase Superfamily.
J Am Chem Soc
; 141(1): 370-387, 2019 01 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30497259
6.
KRAS Binders Hidden in Nature.
Chemistry
; 25(52): 12037-12041, 2019 Sep 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31231840
7.
Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site.
Proc Natl Acad Sci U S A
; 113(27): 7503-8, 2016 07 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-27325754
8.
Structural analyses of von Willebrand factor C domains of collagen 2A and CCN3 reveal an alternative mode of binding to bone morphogenetic protein-2.
J Biol Chem
; 292(30): 12516-12527, 2017 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28584056
9.
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
J Am Chem Soc
; 139(6): 2245-2256, 2017 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28084734
10.
Glycosylation increases the thermostability of human aquaporin 10 protein.
J Biol Chem
; 286(36): 31915-23, 2011 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-21733844
11.
Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism.
PLoS Biol
; 7(6): e1000130, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19529756
12.
Clonal Evolution in Patients with Hormone Receptor Positive, HER-2 Negative Breast Cancer Treated with Chemotherapy or CDK4/6 Inhibitors.
Oncol Res Treat
; 45(5): 248-253, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35220309
13.
Unraveling the Mechanics of a Repeat-Protein Nanospring: From Folding of Individual Repeats to Fluctuations of the Superhelix.
ACS Nano
; 16(3): 3895-3905, 2022 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35258937
14.
Elective Discontinuation of CDK4/6 Inhibitors in Patients with Metastatic Hormone Receptor-Positive, Her-2-Negative Breast Cancer: A Retrospective Single-Center Experience.
Oncol Res Treat
; 44(9): 443-449, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34350900
15.
A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death.
Cell Chem Biol
; 28(6): 835-847.e5, 2021 06 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33662256
16.
Refractive-index-based screening of membrane-protein-mediated transfer across biological membranes.
Biophys J
; 99(1): 124-33, 2010 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-20655840
17.
A lipidic-sponge phase screen for membrane protein crystallization.
Structure
; 16(7): 1003-9, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18611373
18.
Drugging all RAS isoforms with one pocket.
Future Med Chem
; 12(21): 1911-1923, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32779487
19.
Targeting of Fumarate Hydratase from Mycobacterium tuberculosis Using Allosteric Inhibitors with a Dimeric-Binding Mode.
J Med Chem
; 62(23): 10586-10604, 2019 12 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31517489
20.
Author Correction: Temperature dependence of protein-water interactions in a gated yeast aquaporin.
Sci Rep
; 7(1): 17201, 2017 12 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29208910