Detalhe da pesquisa
1.
Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of ß-amyloid-42 aggregation for the treatment of Alzheimer's disease.
Bioorg Med Chem Lett
; 27(6): 1405-1411, 2017 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28216401
2.
Synthesis and structure-activity relationship of 2,6-disubstituted pyridine derivatives as inhibitors of ß-amyloid-42 aggregation.
Bioorg Med Chem Lett
; 26(14): 3330-3335, 2016 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27256911
3.
Discovery and structure activity relationship of small molecule inhibitors of toxic ß-amyloid-42 fibril formation.
J Biol Chem
; 287(41): 34786-800, 2012 Oct 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-22891248
4.
6-Amino quinazolinedione sulfonamides as orally active competitive AMPA receptor antagonists.
Bioorg Med Chem Lett
; 22(2): 996-9, 2012 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22197388
5.
Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.
Alcohol Clin Exp Res
; 33(10): 1749-56, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19572981
6.
Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats.
J Pharmacol Exp Ther
; 326(1): 306-14, 2008 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-18445779
7.
Specific reduction of alcohol's motivational properties by the positive allosteric modulator of the GABAB receptor, GS39783--comparison with the effect of the GABAB receptor direct agonist, baclofen.
Alcohol Clin Exp Res
; 32(9): 1558-64, 2008 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-18616673
8.
Reducing effect of the positive allosteric modulator of the GABA(B) receptor, GS39,783, on alcohol self-administration in alcohol-preferring rats.
Psychopharmacology (Berl)
; 193(2): 171-8, 2007 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-17393141
9.
Attenuation of cocaine-seeking by GABA B receptor agonists baclofen and CGP44532 but not the GABA reuptake inhibitor tiagabine in baboons.
Drug Alcohol Depend
; 89(2-3): 206-13, 2007 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-17234367
10.
Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons.
Psychopharmacology (Berl)
; 189(1): 71-82, 2006 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-17047936
11.
Influence of a GABA(B) and GABA(C) receptor antagonist on sleep-waking cycle in the rat.
Eur J Pharmacol
; 535(1-3): 177-81, 2006 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-16540106
12.
Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.
Biochem J
; 386(Pt 3): 423-31, 2005 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15482257
13.
Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.
J Neurosci
; 24(27): 6086-97, 2004 Jul 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-15240800
14.
Repeated administration of the GABAB receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine-seeking in rats.
Neuropsychopharmacology
; 30(1): 119-28, 2005 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-15266350
15.
The GABAB receptor-positive modulator GS39783 and the GABAB receptor agonist baclofen attenuate the reward-facilitating effects of cocaine: intracranial self-stimulation studies in the rat.
Neuropsychopharmacology
; 30(11): 2065-72, 2005 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-15841108
16.
Prolonged nicotine exposure does not alter GABA(B) receptor-mediated regulation of brain reward function.
Neuropharmacology
; 49(7): 953-62, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16005474
17.
Involvement of gamma-hydroxybutyrate (GHB) and GABA-B receptors in the acute behavioral effects of GHB in baboons.
Psychopharmacology (Berl)
; 180(2): 342-51, 2005 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-15739078
18.
Spontaneous and precipitated withdrawal after chronic intragastric administration of gamma-hydroxybutyrate (GHB) in baboons.
Psychopharmacology (Berl)
; 179(3): 678-87, 2005 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15645222
19.
Reducing effect of the positive allosteric modulators of the GABA(B) receptor, CGP7930 and GS39783, on alcohol intake in alcohol-preferring rats.
Eur J Pharmacol
; 525(1-3): 105-11, 2005 Nov 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-16289452
20.
Effects of GABAergic modulators on food and cocaine self-administration in baboons.
Drug Alcohol Depend
; 80(3): 369-76, 2005 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-16005580