Detalhe da pesquisa
1.
En masse organoid phenotyping informs metabolic-associated genetic susceptibility to NASH.
Cell
; 185(22): 4216-4232.e16, 2022 10 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36240780
2.
Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy.
Nature
; 629(8013): 919-926, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38589574
3.
Tumour-selective activity of RAS-GTP inhibition in pancreatic cancer.
Nature
; 629(8013): 927-936, 2024 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-38588697
4.
Hepatic Deletion of X-Box Binding Protein 1 in FXR Null Mice Leads to Enhanced Liver Injury.
J Lipid Res
; 63(11): 100289, 2022 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36162519
5.
A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis.
Hepatology
; 73(3): 1105-1116, 2021 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32745270
6.
DNA Methylation and Immune Cell Markers Demonstrate Evidence of Accelerated Aging in Patients with Chronic Hepatitis B Virus or Hepatitis C Virus, with or without Human Immunodeficienct Virus Co-infection.
Clin Infect Dis
; 73(1): e184-e190, 2021 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32915202
7.
A chromatin structure-based model accurately predicts DNA replication timing in human cells.
Mol Syst Biol
; 10: 722, 2014 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24682507
8.
Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes.
PLoS Genet
; 8(8): e1002871, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22912592
9.
Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers.
Cancer Discov
; : OF1-OF24, 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593348
10.
Integration of deep learning-based histopathology and transcriptomics reveals key genes associated with fibrogenesis in patients with advanced NASH.
Cell Rep Med
; 4(4): 101016, 2023 04 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-37075704
11.
Tumor-selective effects of active RAS inhibition in pancreatic ductal adenocarcinoma.
bioRxiv
; 2023 Dec 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-38105998
12.
Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis.
Therap Adv Gastroenterol
; 15: 17562848221098243, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35601801
13.
A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation.
Nat Genet
; 54(6): 761-771, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35654975
14.
Targeted analysis of glycomics liquid chromatography/mass spectrometry data.
Anal Bioanal Chem
; 399(2): 727-35, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20953780
15.
Methylation signatures in peripheral blood are associated with marked age acceleration and disease progression in patients with primary sclerosing cholangitis.
JHEP Rep
; 2(1): 100060, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-32039401
16.
DNA methylation signatures reflect aging in patients with nonalcoholic steatohepatitis.
JCI Insight
; 3(2)2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29367468
17.
Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers.
Nat Commun
; 7: 12498, 2016 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27502118
18.
miR-23a impairs bone differentiation in osteosarcoma via down-regulation of GJA1.
Front Genet
; 6: 233, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191074
19.
Replicon: a software to accurately predict DNA replication timing in metazoan cells.
Front Genet
; 5: 378, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-25404939
20.
The exomes of the NCI-60 panel: a genomic resource for cancer biology and systems pharmacology.
Cancer Res
; 73(14): 4372-82, 2013 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23856246