1.
Biochemistry
; 49(47): 10039-41, 2010 Nov 30.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21047142
RESUMO
Tau aggregation is a pathological hallmark of Alzheimer's disease, Parkinson's disease, and many other neurodegenerative disorders known as tauopathies. Tau aggregates take on many forms, and their formation is a multistage process with intermediate stages. Recently, tau oligomers have emerged as the pathogenic species in tauopathies and a possible mediator of amyloid-ß toxicity in Alzheimer's disease. Here, we use a novel, physiologically relevant method (oligomer cross-seeding) to prepare homogeneous populations of tau oligomers and characterize these oligomers in vitro. We show that both Aß and α-synuclein oligomers induce tau aggregation and the formation of ß-sheet-rich neurotoxic tau oligomers.