Detalhe da pesquisa
1.
Increased cathepsin S in Prdm1-/- dendritic cells alters the TFH cell repertoire and contributes to lupus.
Nat Immunol
; 18(9): 1016-1024, 2017 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-28692065
2.
DOTAM-Based, Targeted, Activatable Fluorescent Probes for the Highly Sensitive and Selective Detection of Cancer Cells.
Bioconjug Chem
; 32(4): 702-712, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33691062
3.
Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.
J Am Soc Nephrol
; 27(6): 1635-49, 2016 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26567242
4.
Selective cathepsin S inhibition attenuates atherosclerosis in apolipoprotein E-deficient mice with chronic renal disease.
Am J Pathol
; 185(4): 1156-66, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25680278
5.
Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.
Ann Rheum Dis
; 74(2): 452-63, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24300027
6.
Peptide barcodes meet drug discovery.
Science
; 379(6635): 883, 2023 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36862768
7.
Drug Discovery Efforts to Identify Novel Treatments for Neglected Tropical Diseases - Cysteine Protease Inhibitors.
Curr Med Chem
; 2023 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37916489
8.
Effects of Cathepsin S Inhibition in the Age-Related Dry Eye Phenotype.
Invest Ophthalmol Vis Sci
; 64(11): 7, 2023 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37540176
9.
Molecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural water.
Chemistry
; 18(1): 213-22, 2012 Jan 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22162109
10.
Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations.
J Med Chem
; 65(4): 3606-3615, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35138850
11.
Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase.
Bioorg Med Chem Lett
; 21(11): 3237-42, 2011 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21550236
12.
What We Learned in 25 Years of Interactive Molecular Design Sessions.
ChemMedChem
; 16(18): 2760-2763, 2021 09 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34374230
13.
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Bioorg Med Chem Lett
; 20(17): 5313-9, 2010 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20650636
14.
Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of type-2 diabetes.
Bioorg Med Chem Lett
; 20(2): 594-9, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19969452
15.
2 H-1,2,3-Triazole-Based Dipeptidyl Nitriles: Potent, Selective, and Trypanocidal Rhodesain Inhibitors by Structure-Based Design.
J Med Chem
; 61(8): 3370-3388, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590751
16.
Repurposing a Library of Human Cathepsin L Ligands: Identification of Macrocyclic Lactams as Potent Rhodesain and Trypanosoma brucei Inhibitors.
J Med Chem
; 61(8): 3350-3369, 2018 04 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29590750
17.
Inhibition of the Cysteine Protease Human Cathepsinâ L by Triazine Nitriles: Amideâ â â Heteroarene π-Stacking Interactions and Chalcogen Bonding in the S3 Pocket.
ChemMedChem
; 12(3): 257-270, 2017 02 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27992115
18.
Cathepsin S inhibition suppresses autoimmune-triggered inflammatory responses in macrophages.
Biochem Pharmacol
; 146: 151-164, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28987592
19.
Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.
Sci Rep
; 7(1): 2775, 2017 06 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28584258
20.
Systematic investigation of halogen bonding in protein-ligand interactions.
Angew Chem Int Ed Engl
; 50(1): 314-8, 2011 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-21184410