Detalhe da pesquisa
1.
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Bioorg Med Chem Lett
; 25(4): 908-13, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582600
2.
TAAR1 agonists improve glycemic control, reduce body weight and modulate neurocircuits governing energy balance and feeding.
Mol Metab
; 80: 101883, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-38237896
3.
Cerebrospinal fluid ß-Amyloid turnover in the mouse, dog, monkey and human evaluated by systematic quantitative analyses.
Neurodegener Dis
; 12(1): 36-50, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-22922480
4.
An allosteric modulator of metabotropic glutamate receptors (mGluR2), (+)-TFMPIP, inhibits restraint stress-induced phasic glutamate release in rat prefrontal cortex.
J Neurochem
; 122(3): 619-27, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22578190
5.
Cerebrospinal fluid amyloid-ß (Aß) as an effect biomarker for brain Aß lowering verified by quantitative preclinical analyses.
J Pharmacol Exp Ther
; 342(2): 366-75, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22562771
6.
Pharmacokinetic and Pharmacodynamic Effects of a γ-Secretase Modulator, PF-06648671, on CSF Amyloid-ß Peptides in Randomized Phase I Studies.
Clin Pharmacol Ther
; 107(1): 211-220, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31314925
7.
Quantification of MPTP-induced dopaminergic neurodegeneration in the mouse substantia nigra by laser capture microdissection.
J Neurosci Methods
; 159(2): 291-9, 2007 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-16949674
8.
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Medchemcomm
; 8(4): 730-743, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108792
9.
Norepinephrine but not serotonin reuptake inhibitors enhance theta and gamma activity of the septo-hippocampal system.
Neuropsychopharmacology
; 28(5): 857-64, 2003 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-12637957
10.
Electrical stimulation of the dorsal and median raphe nuclei increases extracellular noradrenaline in rat hippocampus: Evidence for a 5-HT-independent mechanism.
Pharmacol Biochem Behav
; 71(4): 807-13, 2002 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-11888571
11.
Effects of the γ-secretase inhibitor semagacestat on hippocampal neuronal network oscillation.
Front Pharmacol
; 4: 72, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23785331
12.
Age-dependent disruption in hippocampal θ oscillation in amyloid-ß overproducing transgenic mice.
Neurobiol Aging
; 33(7): 1481.e13-23, 2012 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-22227005
13.
Spirocyclic sulfamides as ß-secretase 1 (BACE-1) inhibitors for the treatment of Alzheimer's disease: utilization of structure based drug design, WaterMap, and CNS penetration studies to identify centrally efficacious inhibitors.
J Med Chem
; 55(21): 9224-39, 2012 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22984865
14.
Differential effects of various typical and atypical antipsychotics on plasma glucose and insulin levels in the mouse: evidence for the involvement of sympathetic regulation.
Schizophr Bull
; 36(2): 410-8, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-18703666
15.
The effects of a selective dopamine D2 receptor agonist on behavioral and pathological outcome in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated squirrel monkeys.
J Pharmacol Exp Ther
; 314(3): 1257-66, 2005 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15980058