Detalhe da pesquisa
1.
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways.
Nucleic Acids Res
; 47(3): 1070-1081, 2019 02 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-30535404
2.
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo.
Nucleic Acids Res
; 46(5): 2185-2196, 2018 03 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-29432571
3.
Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles.
Mol Ther
; 26(6): 1520-1528, 2018 06 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29699940
4.
Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier.
Mol Ther
; 26(11): 2580-2591, 2018 11 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30143435
5.
5Î-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo.
Nucleic Acids Res
; 45(13): 7581-7592, 2017 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28591791
6.
Chitosan-Mangafodipir nanoparticles designed for intranasal delivery of siRNA and DNA to brain.
J Drug Deliv Sci Technol
; 43: 453-460, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29805475
7.
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in Mouse Brain.
Bioconjug Chem
; 28(6): 1758-1766, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28462988
8.
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing.
Mol Ther
; 24(10): 1836-1847, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27506293
9.
PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs.
Mol Ther Nucleic Acids
; 29: 116-132, 2022 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-35795486
10.
Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep.
JCI Insight
; 6(24)2021 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34935646
11.
A new frontier in atherosclerotic coronary imaging.
Lancet
; 383(9918): 674-5, 2014 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-24225000
12.
Comparative Colocalization Single-Molecule Spectroscopy (CoSMoS) with Multiple RNA Species.
Methods Mol Biol
; 2113: 23-29, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32006305
13.
Preparation of SNAPf-Beads for Colocalization Single-Molecule Spectroscopy (CoSMoS) of RNA-Protein Complexes.
Methods Mol Biol
; 2113: 17-22, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32006304
14.
A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system.
Nat Biotechnol
; 37(8): 884-894, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31375812
15.
Loading of Extracellular Vesicles with Hydrophobically Modified siRNAs.
Methods Mol Biol
; 1740: 199-214, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-29388146
16.
RNAi modulation of placental sFLT1 for the treatment of preeclampsia.
Nat Biotechnol
; 2018 Nov 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30451990
17.
Loading of Extracellular Vesicles with Chemically Stabilized Hydrophobic siRNAs for the Treatment of Disease in the Central Nervous System.
Bio Protoc
; 7(20)2017 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-28868334
18.
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay.
Nucleic Acid Ther
; 27(6): 323-334, 2017 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-29022758
19.
Synthesis and biological properties of triazole-linked locked nucleic acid.
Chem Commun (Camb)
; 53(63): 8906-8909, 2017 Aug 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28736781
20.
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain.
Mol Ther Nucleic Acids
; 5(8): e344, 2016 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27504598