Detalhe da pesquisa
1.
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.
Cell
; 172(3): 454-464.e11, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29361316
2.
Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome.
Mol Cell
; 80(1): 127-139.e6, 2020 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33007253
3.
Molecular architecture of the human 17S U2 snRNP.
Nature
; 583(7815): 310-313, 2020 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-32494006
4.
Cryo-EM structure of a human spliceosome activated for step 2 of splicing.
Nature
; 542(7641): 318-323, 2017 02 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-28076346
5.
Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome.
Nucleic Acids Res
; 46(22): 12126-12138, 2018 12 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30335160
6.
Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.
RNA
; 23(12): 1770-1779, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28864812
7.
Dynamic Contacts of U2, RES, Cwc25, Prp8 and Prp45 Proteins with the Pre-mRNA Branch-Site and 3' Splice Site during Catalytic Activation and Step 1 Catalysis in Yeast Spliceosomes.
PLoS Genet
; 11(9): e1005539, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26393790
8.
RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.
EMBO J
; 32(21): 2804-18, 2013 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24002212
9.
GraFix: sample preparation for single-particle electron cryomicroscopy.
Nat Methods
; 5(1): 53-5, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18157137
10.
U2 snRNA-protein contacts in purified human 17S U2 snRNPs and in spliceosomal A and B complexes.
Mol Cell Biol
; 26(7): 2803-16, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16537922
11.
Protein composition and electron microscopy structure of affinity-purified human spliceosomal B complexes isolated under physiological conditions.
Mol Cell Biol
; 26(14): 5528-43, 2006 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-16809785
12.
RNA structure and RNA-protein interactions in purified yeast U6 snRNPs.
J Mol Biol
; 356(5): 1248-62, 2006 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-16410014
13.
Molecular architecture of the Saccharomyces cerevisiae activated spliceosome.
Science
; 353(6306): 1399-1405, 2016 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-27562955
14.
Tobramycin affinity tag purification of spliceosomes.
Methods Mol Biol
; 257: 47-64, 2004.
Artigo
em Inglês
| MEDLINE | ID: mdl-14769995
15.
Post-transcriptional spliceosomes are retained in nuclear speckles until splicing completion.
Nat Commun
; 3: 994, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22871813
16.
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome.
Nat Struct Mol Biol
; 15(5): 435-43, 2008 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-18425142
17.
The 5' end of U2 snRNA is in close proximity to U1 and functional sites of the pre-mRNA in early spliceosomal complexes.
Mol Cell
; 25(3): 399-411, 2007 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-17289587
18.
Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.
Science
; 316(5821): 115-20, 2007 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17412961
19.
Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes.
EMBO J
; 26(6): 1737-48, 2007 Mar 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-17332742
20.
Proximity of conserved U6 and U2 snRNA elements to the 5' splice site region in activated spliceosomes.
EMBO J
; 25(11): 2475-86, 2006 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16688215