Detalhe da pesquisa
1.
High molecular weight polyethylene glycol cellular distribution and PEG-associated cytoplasmic vacuolation is molecular weight dependent and does not require conjugation to proteins.
Toxicol Pathol
; 41(7): 970-83, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23788571
2.
Carcinogenicity assessments of biotechnology-derived pharmaceuticals: a review of approved molecules and best practice recommendations.
Toxicol Pathol
; 38(4): 522-53, 2010 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-20472697
3.
A 6-month inhalation study to characterize the toxicity, pharmacokinetics, and pharmacodynamics of human insulin inhalation powder (HIIP) in beagle dogs.
J Aerosol Med
; 20(2): 112-26, 2007.
Artigo
em Inglês
| MEDLINE | ID: mdl-17536950
4.
Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use.
MAbs
; 9(5): 742-755, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28475417
5.
Immunomodulation and lymphoma in humans.
J Immunotoxicol
; 11(1): 1-12, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-23746314
6.
Duration of chronic toxicity studies for biotechnology-derived pharmaceuticals: is 6 months still appropriate?
Regul Toxicol Pharmacol
; 50(1): 2-22, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17998153
7.
Safety assessment of biopharmaceuticals: Japanese perspective on ICH S6 guideline maintenance.
J Toxicol Sci
; 33(3): 277-82, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18670158