Reach and public health implications of proposed new food marketing regulation in Germany: an updated analysis.

Advertising for unhealthy foods adversely affects children's food preferences and intake. The German government published plans to restrict such advertising in February 2023 and has revised them several times since. We assess the reach of the current draft from June 2023, and discuss its public health implications. We show that across 22 product categories covered by the current draft law, the median share of products permitted for marketing to children stands at 55%, with an interquartile range of 11-73%. Resistance from industry groups and from within government poses hurdles and leaves the prospects of the legislation uncertain.

Variation in global and intonational pitch settings among black and white speakers of Southern American English.

This article revisits classic questions about how pitch varies between groups by examining global and intonational pitch differences between black and white speakers from Memphis, Tennessee, using data from read speech to control for stylistic and segmental variables. Results from both mixed-effects regression modeling and smoothing spline analysis of variance find no difference between black and white men in mean F0 and pitch range measures. However, black women produced consistently lower mean F0 than white women. These findings suggest that while pitch patterns in black women's speech remain underexplored in the literature, they may play an important role in shaping attitudes and ideological associations concerning black American speakers in general. Moreover, vocal pitch may be a linguistic variable subject to variation, especially in a context of racialized and gendered linguistic standards.

Validation of Sensititre Dry-Form Broth Microdilution Panels for Susceptibility Testing of Ceftazidime-Avibactam, a Broad-Spectrum-ß-Lactamase Inhibitor Combination.

Ceftazidime-avibactam is a broad-spectrum-ß-lactamase inhibitor combination in late-stage clinical development for the treatment of serious infections. In preparation for clinical microbiology laboratory use, a validation experiment was initiated to evaluate a commercial broth microdilution product (Sensititre dried MIC susceptibility system) compared to reference panels using 525 recent clinical isolates. Among 11 pathogen groups, all had Sensititre MIC/reference MIC ratios predominantly at 1 (47.5% to 97.5%), and automated and manual endpoint results did not differ. Enterobacteriaceae MIC comparisons showed a modest skewing of Sensititre MIC results toward an elevated MIC (33.9%), but the essential agreement was 98.9% with 100.0% reproducibility. In conclusion, Sensititre panels produced accurate ceftazidime-avibactam MIC results, allowing quality MIC guidance for therapy following regulatory approvals.

Validation of a commercial dry-form broth microdilution device (Sensititre) for testing tedizolid, a new oxazolidinone.

Tedizolid, a novel oxazolidinone antibacterial with potent activity against a wide range of Gram-positive pathogens, was recently approved by regulatory authorities for the treatment of acute bacterial skin and skin structure infections. A commercial broth microdilution device (Sensititre; Thermo Fisher Scientific) was validated using 285 selected Gram-positive isolates, and the device was documented to have 100.0% essential and categorical agreement with reference MIC results and excellent MIC endpoint reproducibility.

Effects of the COVID-19 Pandemic on the Wellbeing of LGBTQ+ Individuals in Moldova: A Mixed Methods Analysis.

Research on the effects of the COVID-19 pandemic for LGBTQ+ people is limited, particularly in eastern Europe. This mixed methods study explored the direct and indirect effects of the pandemic on the mental and physical wellbeing of LGBTQ+ individuals in Moldova. From June to the end of July 2022, 86 surveys and 12 interviews were completed by self-identified LGBTQ+ adults in Moldova. Survey data were analyzed with descriptive statistics and interviews were coded and analyzed using the grounded theory methodology. The two data sets were interpreted concurrently to identify emergent themes. Overall, data suggest LGBTQ+ people experienced both negative and positive effects on their mental wellbeing due to the pandemic. Participants expressed feelings of anxiety, loneliness, and depression, and an inability to be their authentic selves. Conversely, participants had more capacity to explore their identities and they demonstrated social support within the LGBTQ+ community. Regarding physical impacts, there were interruptions to transgender medical care and concerns about housing affordability. Findings highlight the unique impacts of the pandemic on LGBTQ+ people and stress the importance of further research in this area and policies and plans to address the needs of LGBTQ+ people in response to the pandemic and future health crises.

Use of the WHO Nutrient Profile Model for Food Marketing Regulation in Germany: Feasibility and Public Health Implications.

INTRODUCTION: Exposure to marketing for foods high in sugar, salt, and fat is considered a key risk factor for childhood obesity. To support efforts to limit such marketing, the World Health Organization Regional Office for Europe has developed a nutrient profile model (WHO NPM). Germany's Federal Ministry of Food and Agriculture plans to use this model in proposed new food marketing legislation, but it has not yet been tested in Germany. The present study therefore assesses the feasibility and implications of implementing the WHO NPM in Germany. METHODS: We applied the WHO NPM to a random sample of 660 food and beverage products across 22 product categories on the German market drawn from Open Food Facts, a publicly available product database. We calculated the share of products permitted for marketing to children based on the WHO NPM, both under current market conditions and for several hypothetical reformulation scenarios. We also assessed effects of adaptations to and practical challenges in applying the WHO NPM. RESULTS: The median share of products permitted for marketing to children across the model's 22 product categories was 20% (interquartile range (IQR) 3-59%) and increased to 38% (IQR 11-73%) with model adaptations for fruit juice and milk proposed by the German government. With targeted reformulation (assuming a 30% reduction in fat, sugar, sodium, and/or energy), the share of products permitted for marketing to children increased substantially (defined as a relative increase by at least 50%) in several product categories (including bread, processed meat, yogurt and cream, ready-made and convenience foods, and savoury plant-based foods) but changed less in the remaining categories. Practical challenges included the ascertainment of the trans-fatty acid content of products, among others. CONCLUSION: The application of the WHO NPM in Germany was found to be feasible. Its use in the proposed legislation on food marketing in Germany seems likely to serve its intended public health objective of limiting marketing in a targeted manner specifically for less healthy products. It seems plausible that it may incentivise reformulation in some product categories. Practical challenges could be addressed with appropriate adaptations and procedural provisions.

Perception in Black and White: Effects of Intonational Variables and Filtering Conditions on Sociolinguistic Judgments With Implications for ASR.

This study tests the effects of intonational contours and filtering conditions on listener judgments of ethnicity to arrive at a more comprehensive understanding on how prosody influences these judgments, with implications for austomatic speech recognition systems as well as speech synthesis. In a perceptual experiment, 40 American English listeners heard phrase-long clips which were controlled for pitch accent type and focus marking. Each clip contained either two H* (high) or two L+H* (low high) pitch accents and a L-L% (falling) boundary tone, and had also previously been labelled for broad or narrow focus. Listeners rated clips in two tasks, one with unmodified stimuli and one with stimuli lowpass filtered at 400 Hz, and were asked to judge whether the speaker was "Black" or "White". In the filtered condition, tokens with the L+H* pitch accent were more likely to be rated as "Black", with an interaction such that broad focus enhanced this pattern, supporting earlier findings that listeners may perceive African American Language as having more variation in possible pitch accent meanings. In the unfiltered condition, tokens with the L+H* pitch accent were less likely to be rated as Black, with no effect of focus, likely due to the fact that listeners relied more heavily on available segmental information in this condition. These results enhance our understanding of cues listeners rely on in making social judgments about speakers, especially in ethnic identification and linguistic profiling, by highlighting perceptual differences due to listening environment as well as predicted meaning of specific intonational contours. They also contribute to our understanding of the role of how human listeners interpret meaning within a holistic context, which has implications for the construction of computational systems designed to replicate the properties of natural language. In particular, they have important applicability to speech synthesis and speech recognition programs, which are often limited in their capacities due to the fact that they do not make such holistic sociolinguistic considerations of the meanings of input or output speech.

Variation, race, and multiracial identity in linguistic research.

What is the relationship between ethnolinguistic communities and ways of speaking? Who is an authentic speaker of an ethnolinguistic variety? In a time where scholarly and public conceptualizations of race and ethnicity are variable and rapidly changing, potential effects on both self-identification and ways of speaking present an area ripe for study. However, linguistics and allied fields have often overlooked individuals and communities that do not neatly conform to well-defined racial categories. As multiracially identified individuals are one of the fastest growing demographic groups in the United States, researchers will necessarily need to address the way that traditional methodologies have excluded individuals and groups who fall outside of these racial and ethnic categories. This presents a unique challenge for sociolinguistics in particular, since we are interested in how people draw on linguistic variation to perform aspects of their identities, including their races and ethnicities. This study examines the ways in which race and ethnicity have been traditionally conceptualized in linguistics and allied fields, and draws on research from other social sciences to see how they have begun to study individuals who fall outside of traditionally pre-existing social categories. The study also briefly discusses the results of one of the first major sociolinguistic studies on multiracially identified participants, which found substantial effects of self-conceptualization and self-identification on linguistic behavior of these participants. Finally, it will address future questions and directions for research at the intersection of personal identity, race, and language. This article is categorized under: Linguistics > Evolution of Language Linguistics > Linguistic Theory Linguistics > Computational Models of Language Linguistics > Language Acquisition.

Accuracy of the Thermo Fisher Scientific (Sensititre™) dry-form broth microdilution MIC product when testing ceftaroline.

Ceftaroline, the active metabolite of the ceftaroline fosamil pro-drug, was the first advanced-spectrum cephalosporin with potent activity against methicillin-resistant Staphylococcus aureus to be approved by the US Food and Drug Administration for acute bacterial skin and skin structure infections. After 4 years of clinical use, few ceftaroline commercial susceptibility testing devices other than agar diffusion methods (disks and stable gradient) are available. Here, we validate a broth microdilution product (Sensititre™; Thermo Fisher Scientific, Cleveland, OH, USA) that achieved 99.2% essential agreement (manual and automated reading) and 95.3-100.0% categorical agreement, with high reproducibility (98.0-100.0%). Sensititre™ MIC values for ceftaroline, however, were slightly skewed toward an elevated value (0.5 × log2 dilution step), greatest when testing for streptococci and Enterobacteriaceae.

Multilaboratory testing of antifungal combinations against a quality control isolate of Candida krusei.

Candida krusei ATCC 6258 was tested by eight laboratories using 96-well plates containing checkerboard pairwise combinations of amphotericin B (AMB), posaconazole (PSC), caspofungin (CSP), and voriconazole (VRC). The methodology led to reproducible results across the laboratories. All drug combinations yielded MICs lower than the MICs of any two drugs tested singly, and combinations of AMB, PSC, CSP, and VRC were indifferent (no antagonism) by summations of fractional inhibitory concentration.