Detalhe da pesquisa
1.
An orthogonal methods assessment of topical drug concentrations in skin and the impact for risk assessment in the viable epidermis.
Regul Toxicol Pharmacol
; 123: 104934, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-33872740
2.
Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat Model.
Toxicol Pathol
; 48(8): 994-1007, 2020 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33252024
3.
Sequence motifs associated with hepatotoxicity of locked nucleic acid--modified antisense oligonucleotides.
Nucleic Acids Res
; 42(8): 4882-91, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24550163
4.
Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
J Med Chem
; 66(1): 460-472, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36562986
5.
Development challenges for carcinogenicity risk assessments of topical drugs.
J Toxicol Sci
; 47(1): 1-11, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34987136
6.
Estrogen receptor expression is required for low-dose resveratrol-mediated repression of aryl hydrocarbon receptor activity.
J Pharmacol Exp Ther
; 335(2): 273-83, 2010 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-20716622
7.
Demonstration of In Vitro to In Vivo Translation of a TYK2 Inhibitor That Shows Cross Species Potency Differences.
Sci Rep
; 10(1): 8974, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32488071
8.
Discovery of Tyrosine Kinase 2 (TYK2) Inhibitor (PF-06826647) for the Treatment of Autoimmune Diseases.
J Med Chem
; 63(22): 13561-13577, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32787094
9.
The aryl hydrocarbon receptor complex and the control of gene expression.
Crit Rev Eukaryot Gene Expr
; 18(3): 207-50, 2008.
Artigo
em Inglês
| MEDLINE | ID: mdl-18540824
10.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30113844
11.
Comparison of hepatic transcription profiles of locked ribonucleic acid antisense oligonucleotides: evidence of distinct pathways contributing to non-target mediated toxicity in mice.
Toxicol Sci
; 138(1): 234-48, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24336348
12.
High-throughput gene silencing and mRNA expression analysis in hepatocyte sandwich cultures.
Curr Protoc Toxicol
; Chapter 14: Unit 14.11, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23408193
13.
Distinct roles for aryl hydrocarbon receptor nuclear translocator and ah receptor in estrogen-mediated signaling in human cancer cell lines.
PLoS One
; 7(1): e29545, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22235307
14.
Inflammatory signaling and aryl hydrocarbon receptor mediate synergistic induction of interleukin 6 in MCF-7 cells.
Cancer Res
; 68(10): 3609-17, 2008 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18483242
15.
Aryl-hydrocarbon receptor activation regulates constitutive androstane receptor levels in murine and human liver.
Hepatology
; 46(1): 209-18, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17596880
16.
Endogenous hepatic expression of the hepatitis B virus X-associated protein 2 is adequate for maximal association with aryl hydrocarbon receptor-90-kDa heat shock protein complexes.
Mol Pharmacol
; 70(6): 2096-107, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16988012
17.
The aryl hydrocarbon (Ah) receptor transcriptional regulator hepatitis B virus X-associated protein 2 antagonizes p23 binding to Ah receptor-Hsp90 complexes and is dispensable for receptor function.
J Biol Chem
; 279(44): 45652-61, 2004 Oct 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-15322122
18.
Divergent roles of hepatitis B virus X-associated protein 2 (XAP2) in human versus mouse Ah receptor complexes.
Biochemistry
; 43(3): 700-9, 2004 Jan 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-14730974