Pesquisa | Biblioteca Virtual em Saúde Fiocruz

1.

Surveying GPCR solubilisation conditions using surface plasmon resonance.

Navratilova, Iva Hopkins; Aristotelous, Tonia; Bird, Louise E; Hopkins, Andrew L.

Anal Biochem ; 556: 23-34, 2018 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-29908863

2.

Automated design of ligands to polypharmacological profiles.

Besnard, Jérémy; Ruda, Gian Filippo; Setola, Vincent; Abecassis, Keren; Rodriguiz, Ramona M; Huang, Xi-Ping; Norval, Suzanne; Sassano, Maria F; Shin, Antony I; Webster, Lauren A; Simeons, Frederick R C; Stojanovski, Laste; Prat, Annik; Seidah, Nabil G; Constam, Daniel B; Bickerton, G Richard; Read, Kevin D; Wetsel, William C; Gilbert, Ian H; Roth, Bryan L; Hopkins, Andrew L.

Nature ; 492(7428): 215-20, 2012 Dec 13.

Artigo em Inglês | MEDLINE | ID: mdl-23235874

3.

Multi-Center Retrospective Evaluation of Screw and Polymethylmethacrylate Constructs for Atlantoaxial Fixation in Dogs.

Stout Steele, Megan W; Hodshon, Amy W; Hopkins, Andrew L; Tracy, Gaemia M; Cohen, Noah D; Kerwin, Sharon C; Boudreau, C Elizabeth; Thomas, William B; Mankin, Joseph M; Levine, Jonathan M.

Vet Surg ; 45(7): 909-915, 2016 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-27580972

4.

A crowdsourcing evaluation of the NIH chemical probes.

Oprea, Tudor I; Bologa, Cristian G; Boyer, Scott; Curpan, Ramona F; Glen, Robert C; Hopkins, Andrew L; Lipinski, Christopher A; Marshall, Garland R; Martin, Yvonne C; Ostopovici-Halip, Liliana; Rishton, Gilbert; Ursu, Oleg; Vaz, Roy J; Waller, Chris; Waldmann, Herbert; Sklar, Larry A.

Nat Chem Biol ; 5(7): 441-7, 2009 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-19536101

5.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Redhead, Martin A; Owen, C David; Brewitz, Lennart; Collette, Amelia H; Lukacik, Petra; Strain-Damerell, Claire; Robinson, Sean W; Collins, Patrick M; Schäfer, Philipp; Swindells, Mark; Radoux, Chris J; Hopkins, Iva Navratilova; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Malla, Tika R; Vangeel, Laura; Vercruysse, Thomas; Thibaut, Jan; Leyssen, Pieter; Nguyen, Tu-Trinh; Hull, Mitchell; Tumber, Anthony; Hallett, David J; Schofield, Christopher J; Stuart, David I; Hopkins, Andrew L; Walsh, Martin A.

Sci Rep ; 11(1): 13208, 2021 06 24.

Artigo em Inglês | MEDLINE | ID: mdl-34168183

6.

Network pharmacology: the next paradigm in drug discovery.

Hopkins, Andrew L.

Nat Chem Biol ; 4(11): 682-90, 2008 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-18936753

7.

Drug discovery: Predicting promiscuity.

Hopkins, Andrew L.

Nature ; 462(7270): 167-8, 2009 Nov 12.

Artigo em Inglês | MEDLINE | ID: mdl-19907483

8.

Evaluation of treatment with a combination of azathioprine and prednisone in dogs with meningoencephalomyelitis of undetermined etiology: 40 cases (2000-2007).

Wong, Michael A; Hopkins, Andrew L; Meeks, John C; Clarke, Jeff D.

J Am Vet Med Assoc ; 237(8): 929-35, 2010 Oct 15.

Artigo em Inglês | MEDLINE | ID: mdl-20946080

9.

Can we rationally design promiscuous drugs?

Hopkins, Andrew L; Mason, Jonathan S; Overington, John P.

Curr Opin Struct Biol ; 16(1): 127-36, 2006 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-16442279

10.

Global mapping of pharmacological space.

Paolini, Gaia V; Shapland, Richard H B; van Hoorn, Willem P; Mason, Jonathan S; Hopkins, Andrew L.

Nat Biotechnol ; 24(7): 805-15, 2006 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-16841068

11.

How many drug targets are there?

Overington, John P; Al-Lazikani, Bissan; Hopkins, Andrew L.

Nat Rev Drug Discov ; 5(12): 993-6, 2006 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-17139284

12.

Mission possible.

Hopkins, Andrew L; Witty, Michael J; Nwaka, Solomon.

Nature ; 449(7159): 166-9, 2007 Sep 13.

Artigo em Inglês | MEDLINE | ID: mdl-17851512

13.

Drug discovery: Know your chemical space.

Hopkins, Andrew L; Bickerton, G Richard.

Nat Chem Biol ; 6(7): 482-3, 2010 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-20559312

14.

The druggable genome.

Hopkins, Andrew L; Groom, Colin R.

Nat Rev Drug Discov ; 1(9): 727-30, 2002 09.

Artigo em Inglês | MEDLINE | ID: mdl-12209152

15.

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.

Navratilova, Iva; Aristotelous, Tonia; Picaud, Sarah; Chaikuad, Apirat; Knapp, Stefan; Filappakopoulos, Panagis; Hopkins, Andrew L.

ACS Med Chem Lett ; 7(12): 1213-1218, 2016 Dec 08.

Artigo em Inglês | MEDLINE | ID: mdl-27994766

16.

Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Redhead, Martin A; Owen, C David; Brewitz, Lennart; Collette, Amelia H; Lukacik, Petra; Strain-Damerell, Claire; Robinson, Sean W; Collins, Patrick M; Schäfer, Philipp; Swindells, Mark; Radoux, Chris J; Hopkins, Iva Navratilova; Fearon, Daren; Douangamath, Alice; von Delft, Frank; Malla, Tika R; Vangeel, Laura; Vercruysse, Thomas; Thibaut, Jan; Leyssen, Pieter; Nguyen, Tu-Trinh; Hull, Mitchell; Tumber, Anthony; Hallett, David J; Schofield, Christopher J; Stuart, David I; Hopkins, Andrew L; Walsh, Martin A.

Sci Rep ; 11(1): 19633, 2021 Sep 28.

Artigo em Inglês | MEDLINE | ID: mdl-34584208

17.

Network pharmacology.

Hopkins, Andrew L.

Nat Biotechnol ; 25(10): 1110-1, 2007 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-17921993

18.

Surface plasmon resonance analysis of seven-transmembrane receptors.

Aristotelous, Tonia; Hopkins, Andrew L; Navratilova, Iva.

Methods Enzymol ; 556: 499-525, 2015.

Artigo em Inglês | MEDLINE | ID: mdl-25857797

19.

The Joint European Compound Library: boosting precompetitive research.

Besnard, Jérémy; Jones, Philip S; Hopkins, Andrew L; Pannifer, Andrew D.

Drug Discov Today ; 20(2): 181-6, 2015 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-25205347

20.

Application of RNAi to Genomic Drug Target Validation in Schistosomes.

Guidi, Alessandra; Mansour, Nuha R; Paveley, Ross A; Carruthers, Ian M; Besnard, Jérémy; Hopkins, Andrew L; Gilbert, Ian H; Bickle, Quentin D.

PLoS Negl Trop Dis ; 9(5): e0003801, 2015 May.

Artigo em Inglês | MEDLINE | ID: mdl-25992548

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Surveying GPCR solubilisation conditions using surface plasmon resonance.

Automated design of ligands to polypharmacological profiles.

Multi-Center Retrospective Evaluation of Screw and Polymethylmethacrylate Constructs for Atlantoaxial Fixation in Dogs.

A crowdsourcing evaluation of the NIH chemical probes.

Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Network pharmacology: the next paradigm in drug discovery.

Drug discovery: Predicting promiscuity.

Evaluation of treatment with a combination of azathioprine and prednisone in dogs with meningoencephalomyelitis of undetermined etiology: 40 cases (2000-2007).

Can we rationally design promiscuous drugs?

Global mapping of pharmacological space.

How many drug targets are there?

Mission possible.

Drug discovery: Know your chemical space.

The druggable genome.

Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.

Publisher Correction: Bispecific repurposed medicines targeting the viral and immunological arms of COVID-19.

Network pharmacology.

Surface plasmon resonance analysis of seven-transmembrane receptors.

The Joint European Compound Library: boosting precompetitive research.

Application of RNAi to Genomic Drug Target Validation in Schistosomes.