Effect of glycemic control on cognitive function in patients with type 1 diabetes mellitus: a systematic review and meta-analysis.

BACKGROUND: It is controversial whether the level of glycemic control in patients with type 1 diabetes mellitus (T1DM) correlates with reduced cognitive function. This study explored the influence of glycemic management quality on cognitive function in T1DM patients by examining the association between glycemic control level and impaired cognitive function. METHODS: The electronic databases PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, China Science and Technology Journal database, Wanfang database, and China Biology Medicine disc database were systematically searched to identify eligible studies published before January 2023. Search, selection, and data extraction were performed by two independent reviewers. RevMan 5.4 software was used for meta-analysis, and standardized mean difference (SMD) between groups was calculated. RESULTS: Six studies involving 351 patients with T1DM were included in this study. Compared with T1DM subjects with good glycemic control, those with poor glycemic control performed worse in full-scale intellectual quotient (P = 0.01, SMD = -0.79, 95%CI = -1.42 to -0.17), but no significant differences were observed in verbal intellectual quotient (P = 0.08, SMD = -1.03, 95%CI = -2.20 to 0.13), memory (P = 0.05, SMD = -0.41, 95%CI = -0.82 to 0.00), and attention (P = 0.23, SMD = -0.26, 95%CI = -0.69 to 0.16). CONCLUSIONS: T1DM patients with suboptimal glycemic control may have a worse cognitive function, mainly focusing on the full-scale intellectual quotient. The current study highlights the significance of maintaining satisfactory glycemic control in T1DM patients to improve their health status and quality of life. Standardized tests should be employed in clinical neuropsychological practice to provide early and complete cognitive assessment of individuals with poor glycemic control. SYSTEMATIC REVIEW REGISTRATION: The study protocol has been registered in the PROSPERO database (CRD42023390456).

Excellent capture of Pb(II) and Cu(II) by hierarchical nanoadsorbent Fe3O4@SiO2@PAA-SO3H: A combined experimental and theoretical study.

A novel magnetic nanoadsorbent (Fe3O4@SiO2@PAA-SO3H) was synthesized by grafting acrylic acid and sulfonic group to Fe3O4@SiO2 using a facile cross-link technology. The adsorbent presented water-stability and biocompatibility in wastewater, which exhibited high-selectivity capture for Pb(II) and Cu(II) of 182.5 mg/g and 250.7 mg/g, respectively, at pH 6.0. Furthermore, the adsorption-desorption processes show that nanoadsorbent still retains high uptake capacity after 6 cycles, revealing structural stability and advanced recycling. Effects from other ions existed weak interference in removal of Pb(II) and Cu(II). Meanwhile, the mechanism was further analyzed from both electrostatic potential (ESP) and average local ionization energy (ALIE) based on the density functional theory (DFT). The results indicate that interaction among nanoadsorbent and heavy metal ions is bridged by oxygen active sites. As the Fe3O4@SiO2@PAA-SO3H adsorbent is a hierarchical, highly water-dispersible and biocompatible adsorbent, it is a potential new treatment option for wastewater.

Study of the fragmentation mechanism of novel functionalized macrocycles by Fourier transform ion cyclotron resonance mass spectrometry.

Liquid secondary ion mass spectrometry (L-SIMS) of six new functionalized macrocycles was investigated. All six compounds yielded abundant fragment ions and protonation molecular ions [M + H](+) under L-SIMS conditions. The proposed fragmentation mechanisms were supported by high-resolution accurate mass data from Fourier transform ion cyclotron resonance mass spectrometric and MS(n) experiments on using sustained off-resonance irradiation collision-induced dissociation.