Detalhe da pesquisa
1.
LRRK2 Inhibition by BIIB122 in Healthy Participants and Patients with Parkinson's Disease.
Mov Disord
; 38(3): 386-398, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36807624
2.
The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons.
J Neurosci
; 37(46): 11074-11084, 2017 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28993483
3.
DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury.
Proc Natl Acad Sci U S A
; 110(10): 4039-44, 2013 Mar 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-23431164
4.
Genetic analysis reveals that amyloid precursor protein and death receptor 6 function in the same pathway to control axonal pruning independent of ß-secretase.
J Neurosci
; 34(19): 6438-47, 2014 May 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-24806670
5.
Differential regulation of evoked and spontaneous neurotransmitter release by C-terminal modifications of complexin.
Mol Cell Neurosci
; 52: 161-72, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23159779
6.
Complexin controls spontaneous and evoked neurotransmitter release by regulating the timing and properties of synaptotagmin activity.
J Neurosci
; 32(50): 18234-45, 2012 Dec 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23238737
7.
A leucine-rich repeat kinase 2 (LRRK2) pathway biomarker characterization study in patients with Parkinson's disease with and without LRRK2 mutations and healthy controls.
Clin Transl Sci
; 16(8): 1408-1420, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37177855
8.
Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease.
Sci Transl Med
; 14(648): eabj2658, 2022 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35675433
9.
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Sci Rep
; 11(1): 12900, 2021 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34145320
10.
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease.
Front Neurosci
; 14: 865, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33013290
11.
Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study.
Neurology
; 95(24): e3428-e3437, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32999056
12.
Dual leucine zipper kinase-dependent PERK activation contributes to neuronal degeneration following insult.
Elife
; 62017 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-28440222
13.
JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis.
J Cell Biol
; 202(5): 747-63, 2013 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-23979718