RESUMO
Subungual squamous cell carcinoma is very rare, but it is the most frequent primary malignant tumor of the nail bed. Therefore, its diagnosis and treatment are crucial to ensure a favorable prognosis. We present the sonographic findings in a case of a subungual squamous cell carcinoma. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46:212-214, 2018.
Assuntos
Carcinoma de Células Escamosas/diagnóstico por imagem , Doenças da Unha/diagnóstico por imagem , Ultrassonografia/métodos , Idoso de 80 Anos ou mais , Amputação Cirúrgica , Carcinoma de Células Escamosas/cirurgia , Diagnóstico Diferencial , Feminino , Humanos , Doenças da Unha/cirurgia , Unhas/diagnóstico por imagem , Unhas/cirurgiaRESUMO
A 75-year-old man presented to the dermatology clinic with an asymptomatic lesion on his right plantar surface. The lesion had progressively grown for two months. Physical examination revealed an erythematous and slightly scaly nodule measuring 10x10 mm. Dermoscopy examination showed central diffuse erythema with small red globules. A punch-biopsy revealed a proliferation of irregularly branched small vessels with collapsed lumen, extending in an infiltrative pattern in the superficial and deep dermis. Although this is a rare location, a diagnosis of microvenular hemangioma was made.
Assuntos
Doenças do Pé/diagnóstico , Hemangioma/diagnóstico , Neoplasias Cutâneas/diagnóstico , Pele/patologia , Idoso , Biópsia , Diagnóstico Diferencial , Eritema , Doenças do Pé/patologia , Hemangioma/patologia , Humanos , Masculino , Neoplasias Cutâneas/patologiaRESUMO
Inhibitors of tumor necrosis factor-alpha (anti-TNF-alpha) are widely used in different medical specialties. The main adverse effect of these agents is the increased risk of infection. We report the case of a 30-year-old man with ankylosing spondylitis who had begun receiving golimumab two weeks earlier. He presented with a 10-day history of salmon-colored lesions on trunk, palms and soles. The clinical suspicion was secondary syphilis. Treponemal and nontreponemal tests confirmed the diagnosis of syphilis. Lumbar puncture was also performed, although there was no neurological involvement, to rule out neurosyphilis. Cases of syphilis in patients in treatment with TNF-alpha inhibitors are uncommon in the literature and there are no established protocols.
Assuntos
Anticorpos Monoclonais/efeitos adversos , Sífilis/induzido quimicamente , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Adulto , Anticorpos Monoclonais/uso terapêutico , Humanos , Masculino , Espondilite Anquilosante/tratamento farmacológicoAssuntos
Anti-Inflamatórios/administração & dosagem , Clobetasol/administração & dosagem , Dermatoses da Mão/diagnóstico , Creme para a Pele/administração & dosagem , Síndrome de Sweet/diagnóstico , Idoso de 80 Anos ou mais , Biópsia , Feminino , Dermatoses da Mão/tratamento farmacológico , Dermatoses da Mão/imunologia , Dermatoses da Mão/patologia , Humanos , Pele/imunologia , Pele/patologia , Síndrome de Sweet/tratamento farmacológico , Síndrome de Sweet/imunologia , Síndrome de Sweet/patologia , Resultado do TratamentoRESUMO
Los fármacos inhibidores del factor de necrosis tumoral alfa (anti-TNF alfa) son ampliamente utilizados en diversas especialidades médicas. El principal efecto adverso de estos fármacos es el aumento del riesgo de infecciones. Presentamos el caso de un varón de 30 años con espondilitis anquilosante, en tratamiento desde hacía 2 semanas con golimumab, que consulta por lesiones asalmonadas en tronco, palmas y plantas de 10 días de evolución. Con la sospecha de un secundarismo luético se solicitaron pruebas treponémicas y no treponémicas que confirmaron el diagnóstico. Asimismo se solicitó una punción lumbar, aunque no existía sintomatología neurológica, para descartar neurosífilis. Los casos de sífilis en pacientes en tratamiento con anti-TNF alfa son excepcionales en la literatura y no hay protocolos establecidos que nos guíen sobre cómo actuar ante esta situación
Inhibitors of tumor necrosis factor-alpha (anti-TNF-alpha) are widely used in different medical specialties. The main adverse effect of these agents is the increased risk of infection. We report the case of a 30-year-old man with ankylosing spondylitis who had begun receiving golimumab two weeks earlier. He presented with a 10-day history of salmon-colored lesions on trunk, palms and soles. The clinical suspicion was secondary syphilis. Treponemal and nontreponemal tests confirmed the diagnosis of syphilis. Lumbar puncture was also performed, although there was no neurological involvement, to rule out neurosyphilis. Cases of syphilis in patients in treatment with TNF-alpha inhibitors are uncommon in the literature and there are no established protocols
Assuntos
Humanos , Masculino , Adulto , Anticorpos Monoclonais/efeitos adversos , Sífilis/induzido quimicamente , Fator de Necrose Tumoral alfa/antagonistas & inibidores , Anticorpos Monoclonais/uso terapêutico , Espondilite Anquilosante/tratamento farmacológicoAssuntos
Mucinoses/patologia , Prurido/patologia , Adulto , Biópsia , Diagnóstico Diferencial , Feminino , HumanosRESUMO
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