1.
Bioorg Med Chem Lett
; 29(11): 1278-1281, 2019 06 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-30981579
RESUMO
In this work, the synthesis and the pharmacological evaluation of diphenoxyadamantane alkylamines Ia-f and IIa-f is described. The new diphenoxy-substituted adamantanes share structural features present in trypanocidal and antitubercular agents. 1-Methylpiperazine derivative Ia is the most potent against T. brucei compound, whilst its hexylamine congener IIf exhibits a significant antimycobacterial activity.