[Analysis of liver function in patients with Turner syndrome (TS) and in patients with secondary hypogonadism with estrogen and estrogen- progestagens replacement therapy: a preliminary report]. / Ocena czynnosci watroby u chorych z zespolem Turnera oraz u pacjentek z wtórna niedoczynnoscia gonad leczonych estrogenami i preparatami estro-progestagenowymi--doniesienie wstepne.

OBJECTIVES: Abnormalities of liver function tests were been reported in adults with TS and in patients with oestrogen replacement therapy. DESIGN: The aim of this study was to evaluate the prevalence of liver disease in patients before or with oestrogen therapy. MATERIALS: 79 patients, aged 13(2/12) to 60(4/12), for oestrogen replacement therapy: 13--with secondary hypogonadism (group I), 29--with TS (group II), 19--with menopause (group IV) and 18--with TS, aged 2 to 16(11/12), before oestrogen therapy (group III). METHODS: All patients were tested for liver function tests (ALAT, GGTP, total bilirubin), and patients I-III groups for serum markers of HBV and HCV infection. RESULTS: The frequency of HBV/HCV infection was 38.3% in group I, 13.7%--in group II, 16.7%--in group III. In 13.7% patients of group II and in 16.7% patients of group III the liver disease had been classified as cryptogenic. CONCLUSIONS: The prevalence of HBV/HCV infection in patients with hypogonadism and the prevalence of cryptogenic liver disease in patients with TS, seems to be relatively high. In TS liver function test should be investigated as well before oestrogen therapy and should be turned during the follow up.

[Analysis of the course of pregnancies and labor in girls under 18 years of age]. / Analiza przebiegu ciazy i porodu u pacjentek przed 18 rokiem zycia.

Authors analysed the course of pregnancy and labor at 141 under 18 aged girls, between 1981-1990. The rise of number of labors at teen-agers was observed in the last 5 years. This tendency should pay our attention on this group of patients.

PIP: During 1981-90, there were 141 births to women under the age of 18 from among 22,037 deliveries at the II Department of the Obstetrical and Gynecological Clinic of the Academy of Medicine in Warsaw. The control group consisted of 141 consecutive primiparas aged 19-30. Among the 22,037 births, the underage women accounted for 0.64%. 10 women were under 16 years of age, and two patients each were 13 and 14 years of age, respectively, while 23 were aged 16, and 108 were aged 17. The percentage of pregnant adolescents increased from 0.13% in 1982 to 0.84% in 1986 and to 1.24% in 1990. There were 47 (33.67%) pregnancy complications among adolescents and 55 (39%) among adults. The threat of premature birth occurred in 11 adolescents (7.0%) vs. 13 adults (9.22%); premature discharge of amniotic fluid in 21 adolescents (14.89%) and 25 adults (17.73%); EPH gestosis in 4 adolescents (2.84%) and 5 adults (3.55%); infection of the urinary tract in 7 adolescents (4.96%) and 10 adults (7.10%). Normal delivery occurred in 124 (87.94%) adolescents and in 112 (79.4%) adults. Cesarean sections were performed in 11 (7.8%) adolescents and 24 (17.1%) adult primiparas. There were 26 (18.4%) instances of delivery complications in adolescents and 66 (46.7%) in adults. Incomplete delivery occurred in 21 (14.9%) adolescents vs. 23 (16.3%) adults. Significantly more (39) cases of rupture of the uterine cervix occurred in adults (27.6%) than in adolescents (4 instances or 2.8%). The duration of labor ranged from 2 hours to 12.5 hours in the group of adolescents with an average of 7.1 hours compared to from 2 hours to 25 hours with an average of 7.9 hours in the control group. The average values in the first minute of life amounted to 8.85 marks on the Apgar score in the case group compared to 9.36 scores in controls. The average birth weight of neonates was 3190 g in the case group compared to 3284 g in the control group.