Detalhe da pesquisa
1.
Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia.
Cell
; 167(1): 171-186.e15, 2016 Sep 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-27641501
2.
Alternative to the soft-agar assay that permits high-throughput drug and genetic screens for cellular transformation.
Proc Natl Acad Sci U S A
; 112(18): 5708-13, 2015 May 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25902495
3.
Overexpression of histone demethylase Fbxl10 leads to enhanced migration in mouse embryonic fibroblasts.
Exp Cell Res
; 348(2): 123-131, 2016 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27646113
4.
Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells.
Proc Natl Acad Sci U S A
; 111(29): 10574-9, 2014 Jul 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25002509
5.
The H3K4me3 histone demethylase Fbxl10 is a regulator of chemokine expression, cellular morphology, and the metabolome of fibroblasts.
J Biol Chem
; 287(37): 30984-92, 2012 Sep 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-22825849
6.
Pan-PI3K inhibition with copanlisib overcomes Treg- and M2-TAM-mediated immune suppression and promotes anti-tumor immune responses.
Clin Exp Med
; 23(8): 5445-5461, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37935952
7.
Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor.
Int J Cancer
; 131(11): 2704-9, 2012 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22447389
8.
Lysine-specific demethylase 1 (LSD1) and histone deacetylase 1 (HDAC1) synergistically repress proinflammatory cytokines and classical complement pathway components.
Biochem Biophys Res Commun
; 421(4): 665-70, 2012 May 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-22542627
9.
De novo pyrimidine synthesis is a targetable vulnerability in IDH mutant glioma.
Cancer Cell
; 40(9): 939-956.e16, 2022 09 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35985343
10.
Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface.
Biochem J
; 430(1): 87-95, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20518742
11.
Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology.
Carcinogenesis
; 31(3): 512-20, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20042638
12.
The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies.
Leukemia
; 33(10): 2403-2415, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30940908
13.
Genome-scale identification of transcription factors that mediate an inflammatory network during breast cellular transformation.
Nat Commun
; 9(1): 2068, 2018 05 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29802342