Relation Between Exposure to Tobacco Smoke Assessed by Serum Cotinine Concentration and Questionnaire Method, and Serum Renalase Concentration-the Importance of the Coexistence of Arterial Hypertension and Other Cardiovascular Diseases.

Exposure to tobacco smoke (ETS) is one of the main risk factors for cardiovascular disease (CVD). Renalase is a protein that may play a role in the pathogenesis of CVD. The aim of the study was to assess the relationship between ETS and serum renalase concentration. A group of 109 patients was recruited for this study (49.7 ± 14.7 years). In accordance with the questionnaire, patients were divided into the following subgroups: subgroup A- declaring themselves active smokers (n = 36), subgroup B- declaring themselves non-smokers and exposed to environmental tobacco smoke (n = 35), subgroup C- declaring themselves non-smokers and not exposed to environmental tobacco smoke (n = 38). The same patients were divided based on cotinine concentration into the following subgroups: subgroup D- active smokers (n = 42), subgroup E- non-smokers exposed to environmental tobacco smoke (n = 66), and subgroup F- non-smokers not exposed to environmental tobacco smoke (n = 1). Serum cotinine concentration and serum renalase concentration were measured using ELISA tests. Serum renalase concentration was statistically significantly higher in subgroup C than in subgroups A and B and in subgroup E and F than in D. There was a negative correlation between serum cotinine concentration and serum renalase concentration (r = -0.41, p < 0.05). Regression analysis showed that higher BMI, higher diastolic blood pressure, coronary artery disease and higher serum cotinine concentration are independent risk factors of lower serum renalase concentration. The questionnaire method of assessing exposure to tobacco smoke was characterized by high sensitivity, but only moderate specificity, especially in terms of assessing environmental exposure to tobacco smoke. In summary, the study showed an independent relationship between exposure to tobacco smoke and lower serum renalase concentration.

The Relationship between Body Composition and Physical Activity Level in Students of Medical Faculties.

Maintaining an active lifestyle is crucial for good health. Markers of health risk include tissue components. This study aimed to indicate which body composition elements create the strongest correlations with physical activity performed in young students of medical faculties. The study group consisted of 75 students (33 men and 42 women) from Wroclaw Medical University. Each student underwent accelerometer and anthropometric measurements and body composition analysis. Both men and women had similar physical activity levels. The study found that the amount of vigorous physical activity correlated significantly with the basal metabolic rate (BMR), fat, water and muscle content, fat-free mass (FFM), bone mass, extracellular to intracellular water ratio (ECW/ICW), and phase angle (PA), with r~ ± (0.2-0.4). The amount of moderate physical activity correlated with body mass, body mass index (BMI), BMR, FFM, and bone mass, with r~0.3-0.5. There are dimorphic differences in the strength of correlations between physical activity and elements of body composition. A greater amount of moderate and vigorous physical activity is associated with greater FFM and bone mass in men, which causes BMI to increase as well (in this case, higher BMI is not a sign of being overweight). For women, the beneficial effect of higher amounts of vigorous physical activity on reducing fat content and increasing muscle mass is more pronounced. In both men and women, an improvement in hydration is evident with increased vigorous physical activity volume.