Graphene Hybrid Tough Hydrogels with Nanostructures for Tissue Regeneration.

Over the past few decades, hydrogels have attracted considerable attention as promising biomedical materials. However, conventional hydrogels require improved mechanical properties, such as brittleness, which significantly limits their widespread use. Recently, hydrogels with remarkably improved toughness have been developed; however, their low biocompatibility must be addressed. In this study, we developed a tough graphene hybrid hydrogel with nanostructures. The resultant hydrogel exhibited remarkable mechanical properties while representing an aligned nanostructure that resembled the extracellular matrix of soft tissue. Owing to the synergistic effect of the topographical properties, and the enhanced biochemical properties, the graphene hybrid hydrogel had excellent stretchability, resilience, toughness, and biocompatibility. Furthermore, the hydrogel displayed outstanding tissue regeneration capabilities (e.g., skin and tendons). Overall, the proposed graphene hybrid tough hydrogel may provide significant insights into the application of tough hydrogels in tissue regeneration.

Micro/nanoengineered agricultural by-products for biomedical and environmental applications.

Agriculturally derived by-products generated during the growth cycles of living organisms as secondary products have attracted increasing interest due to their wide range of biomedical and environmental applications. These by-products are considered promising candidates because of their unique characteristics including chemical stability, profound biocompatibility and offering a green approach by producing the least impact on the environment. Recently, micro/nanoengineering based techniques play a significant role in upgrading their utility, by controlling their structural integrity and promoting their functions at a micro and nano scale. Specifically, they can be used for biomedical applications such as tissue regeneration, drug delivery, disease diagnosis, as well as environmental applications such as filtration, bioenergy production, and the detection of environmental pollutants. This review highlights the diverse role of micro/nano-engineering techniques when applied on agricultural by-products with intriguing properties and upscaling their wide range of applications across the biomedical and environmental fields. Finally, we outline the future prospects and remarkable potential that these agricultural by-products hold in establishing a new era in the realms of biomedical science and environmental research.

Colorimetric Sensor Based on Hydroxypropyl Cellulose for Wide Temperature Sensing Range.

Recently, temperature monitoring with practical colorimetric sensors has been highlighted because they can directly visualize the temperature of surfaces without any power sources or electrical transducing systems. Accordingly, several colorimetric sensors that convert the temperature change into visible color alteration through various physical and chemical mechanisms have been proposed. However, the colorimetric temperature sensors that can be used at subzero temperatures and detect a wide range of temperatures have not been sufficiently explored. Here, we present a colorimetric sensory system that can detect and visualize a wide range of temperatures, even at a temperature below 0 °C. This system was developed with easily affordable materials via a simple fabrication method. The sensory system is mainly fabricated using hydroxypropyl cellulose (HPC) and ethylene glycol as the coolant. In this system, HPC can self-assemble into a temperature-responsive cholesteric liquid crystalline mesophase, and ethylene glycol can prevent the mesophase from freezing at low temperatures. The colorimetric sensory system can quantitatively visualize the temperature and show repeatability in the temperature change from -20 to 25 °C. This simple and reliable sensory system has great potential as a temperature-monitoring system for structures exposed to real environments.

Biofouling-resistant tubular fluidic devices with magneto-responsive dynamic walls.

Biofouling of tubular fluidic devices limits the stability, accuracy, and long-term uses of lab-on-a-chip systems. Healthcare-associated infection by biofilm formations on body-indwelling and extracorporeal tubular medical devices is also a major cause of mortality and morbidity in patients. Although diverse antifouling techniques have been developed to prevent bacterial contamination of fluidic devices based on antimicrobial materials or nanoscale architectures, they still have limitations in biocompatibility, long-term activity, and durability. In this study, a new conceptual tubular fluidic device model that can effectively suppress bacterial contamination based on dynamic surface motions without using bactericidal materials or nanostructures is proposed. The fluidic device is composed of a magneto-responsive multilayered composite. The composite tube can generate dynamic surface deformation with controlled geometries along its inner wall in response to a remote magnetic field. The magnetic field-derived surface wave induces the generation of vortices near the inner wall surface of the tube, enabling sweeping of bacterial cells from the surface. As a result, the dynamic composite tube could effectively prevent biofilm formation for an extended time of 14 days without surface modification with chemical substances or nanostructures.

A Pressure-Insensitive Self-Attachable Flexible Strain Sensor with Bioinspired Adhesive and Active CNT Layers.

Flexible tactile sensors are required to maintain conformal contact with target objects and to differentiate different tactile stimuli such as strain and pressure to achieve high sensing performance. However, many existing tactile sensors do not have the ability to distinguish strain from pressure. Moreover, because they lack intrinsic adhesion capability, they require additional adhesive tapes for surface attachment. Herein, we present a self-attachable, pressure-insensitive strain sensor that can firmly adhere to target objects and selectively perceive tensile strain with high sensitivity. The proposed strain sensor is mainly composed of a bioinspired micropillar adhesive layer and a selectively coated active carbon nanotube (CNT) layer. We show that the bioinspired adhesive layer enables strong self-attachment of the sensor to diverse planar and nonplanar surfaces with a maximum adhesion strength of 257 kPa, while the thin film configuration of the patterned CNT layer enables high strain sensitivity (gauge factor (GF) of 2.26) and pressure insensitivity.

Multifunctional Smart Ball Sensor for Wireless Structural Health Monitoring in a Fire Situation.

A variety of sensor systems have been developed to monitor the structural health status of buildings and infrastructures. However, most sensor systems for structural health monitoring (SHM) are difficult to use in extreme conditions, such as a fire situation, because of their vulnerability to high temperature and physical shocks, as well as time-consuming installation process. Here, we present a smart ball sensor (SBS) that can be immediately installed on surfaces of structures, stably measure vital SHM data in real time and wirelessly transmit the data in a high-temperature fire situation. The smart ball sensor mainly consists of sensor and data transmission module, heat insulator and adhesive module. With the integrated device configuration, the SBS can be strongly attached to the target surface with maximum adhesion force of 233.7-N and stably detect acceleration and temperature of the structure without damaging the key modules of the systems even at high temperatures of up to 500 °C while ensuring wireless transmission of the data. Field tests for a model pre-engineered building (PEB) structure demonstrate the validity of the smart ball sensor as an instantly deployable, high-temperature SHM system. This SBS can be used for SHM of a wider variety of structures and buildings beyond PEB structures.

Highly flexible and self-adaptive dry adhesive end-effectors for precision robotics.

Many research groups have studied biomimetic functional surfaces for practical applications. Dry adhesives inspired by the gecko foot consist of hierarchical and numerous micro/nano hairs and can achieve pull-off strengths for vertical and shear adhesion of up to 20 N cm-2. However, when detachment of the nearly dry adhesive is carried out by peeling, the pull-off strength of the dry adhesive in the tilted state is remarkably reduced. In this study, an enhanced pull-off strength dry adhesive in the tilted state was fabricated by using a strategy that reduces the restoring force from the bending moment. An experiment with various column-type dry adhesives was implemented to find the relation between the pull-off strength in the tilted state and the bending resistance of the dry adhesive. The feasibility of using a dry adhesive in the tilted state was observed through a glass-lifting experiment. This strategy could be widely utilized in many practical applications, such as robotics.

Woven Kevlar Fiber/Polydimethylsiloxane/Reduced Graphene Oxide Composite-Based Personal Thermal Management with Freestanding Cu-Ni Core-Shell Nanowires.

Thermotherapy is a widespread technique that provides relief for muscle spasms and joint injuries. A great deal of energy is used to heat the surrounding environment, and heat emitted by the human body is wasted on our surroundings. Herein, a woven Kevlar fiber (WKF)-based personal thermal management device was fabricated by directly growing vertical copper-nickel (Cu-Ni) nanowires (NWs) on the WKF surface using a hydrothermal method. The treated WKF was combined with reduced graphene oxide (rGO) dispersed in polydimethylsiloxane (PDMS) to form composites using vacuum-assisted resin transfer molding (VARTM). This WKF-based personal thermal management system contained a conductive network of metallic NWs and rGO that promoted effective Joule heating and reflected back the infrared (IR) radiation emitted by the human body. It thus behaved as a type of thermal insulation. The Cu-Ni NWs were synthesized with a tunable Ni layer on Cu core NWs to enhance the oxidation resistance of the Cu NWs. The combined effect of the NW networks and rGO enabled a surface temperature of 70 °C to be attained on application of 1.5 V to the composites. The Cu3Ni1-WKF/PDMS provided 43% more thermal insulation and higher IR reflectance than bare WKF/PDMS. The absorbed impact energy and tensile strength was highest for the Cu1Ni3- and rGO-integrated WKF/PDMS samples. Those Cu-Ni NWs having higher Ni contents displayed better mechanical properties and those with higher Cu contents showed higher Joule heating performance and IR reflectivity at a given rGO loading. The composite shows sufficient breathability and very high durability. The high flexibility of the composites and their ability to generate sufficient heat during various human motions ensures their suitability for wearable applications.

Hybrid Architectures of Heterogeneous Carbon Nanotube Composite Microstructures Enable Multiaxial Strain Perception with High Sensitivity and Ultrabroad Sensing Range.

Low-dimensional nanomaterials are widely adopted as active sensing elements for electronic skins. When the nanomaterials are integrated with microscale architectures, the performance of the electronic skin is significantly altered. Here, it is shown that a high-performance flexible and stretchable electronic skin can be produced by incorporating a piezoresistive carbon nanotube composite into a hierarchical topography of micropillar-wrinkle hybrid architectures that mimic wrinkles and folds in human skin. Owing to the unique hierarchical topography of the hybrid architectures, the hybrid electronic skin exhibits versatile and superior sensing performance, which includes multiaxial force detection (normal, bending, and tensile stresses), remarkable sensitivity (20.9 kPa-1 , 17.7 mm-1 , and gauge factor of 707 each for normal, bending, and tensile stresses), ultrabroad sensing range (normal stress = 0-270 kPa, bending radius of curvature = 1-6.5 mm, and tensile strain = 0-50%), sensing tunability, fast response time (24 ms), and high durability (>10 000 cycles). Measurements of spatial distributions of diverse mechanical stimuli are also demonstrated with the multipixel electronic skin. The stress-strain behavior of the hybrid structure is investigated by finite element analysis to elucidate the underlying principle of the superior sensing performance of the electronic skin.

Highly durable and unidirectionally stooped polymeric nanohairs for gecko-like dry adhesive.

Gecko-like dry adhesive using high aspect ratio polymeric nanohairs has insuperable limitations, although it has huge potential in many applications. Repeated harsh contacts on a target substrate lead to physical collapse of nanohairs and significant degradation of the adhesion property, because the polymeric nanohairs are quite fragile due to poor mechanical robustness. Herein, we demonstrate a highly robust gecko-like dry adhesive with unidirectionally stooped polymeric nanohairs (diameter 100 nm) with a high aspect ratio (∼9) using an ultrathin metal coating. 100 cycles of repeated adhesion tests with 1 N preloading force did not significantly degrade adhesion or cause collapse of nanohairs. We believe that this approach allows gecko-like dry adhesive to be utilized in many related applications and diverse industry interests.

Bacterial recognition of silicon nanowire arrays.

Understanding how living cells interact with nanostructures is integral to a better understanding of the fundamental principles of biology and the development of next-generation biomedical/bioenergy devices. Recent studies have demonstrated that mammalian cells can recognize nanoscale topographies and respond to these structures. From this perspective, there is a growing recognition that nanostructures, along with their specific physicochemical properties, can also be used to regulate the responses and motions of bacterial cells. Here, by utilizing a well-defined silicon nanowire array platform and single-cell imaging, we present direct evidence that Shewanella oneidensis MR-1 can recognize nanoscale structures and that their swimming patterns and initial attachment locations are strongly influenced by the presence of nanowires on a surface. Analyses of bacterial trajectories revealed that MR-1 cells exhibited a confined diffusion mode in the presence of nanowires and showed preferential attachment to the nanowires, whereas a superdiffusion mode was observed in the absence of nanowires. These results demonstrate that nanoscale topography can affect bacterial movement and attachment and play an important role during the early stages of biofilm formation.

Sustainable Biofilm Inhibition Using Chitosan-Mesoporous Nanoparticle-Based Hybrid Slippery Composites.

In recent decades, extensive research has been directed toward mitigating microbial contamination and preventing biofilm formation. However, many conventional antibiofilm methods rely on hazardous and toxic substances, neglecting potential risks to human health and the environment. Moreover, these approaches often rely on single-strategy mechanisms, utilizing either bactericidal or fouling-resistant agents, which have shown limited efficacy in long-term biofilm suppression. In this study, we propose an efficient and sustainable biofilm-resistant slippery hybrid slippery composite. This composite integrates nontoxic and environmentally friendly materials including chitosan, silicone oil-infused polydimethylsiloxane, and mesoporous silica nanoparticles in a synergistic manner. Leveraging the bacteria-killing properties of chitosan and the antifouling capabilities of the silicone oil layer, the hybrid composite exhibits robust antibiofilm performance against both Gram-positive and Gram-negative bacteria. Furthermore, the inclusion of mesoporous silica nanoparticles enhances the oil absorption capacity and self-replenishing properties, ensuring exceptional biofilm inhibition even under harsh conditions such as exposure to high shear flow and prolonged incubation (7 days). This approach offers promising prospects for developing effective biofilm-resistant materials with a reduced environmental impact and improved long-term performance.

A Sensorized Soft Robotic Hand with Adhesive Fingertips for Multimode Grasping and Manipulation.

Soft robotic grippers excel at achieving conformal and reliable contact with objects without the need for complex control algorithms. However, they still lack in grasp and manipulation abilities compared with human hands. In this study, we present a sensorized multi-fingered soft gripper with bioinspired adhesive fingertips that can provide both fingertip-based adhesion grasping and finger-based form closure grasping modes. The gripper incorporates mushroom-like microstructures on its adhesive fingertips, enabling robust adhesion through uniform load shearing. A single fingertip exhibits a maximum load capacity of 4.18 N against a flat substrate. The soft fingers have multiple joints, and each joint can be independently actuated through pneumatic control. This enables diverse bending motions and stable grasping of various objects, with a maximum load capacity of 28.29 N for three fingers. In addition, the soft gripper is equipped with a kirigami-patterned stretchable sensor for motion monitoring and control. We demonstrate the effectiveness of our design by successfully grasping and manipulating a diverse range of objects with varying shapes, sizes, and curvatures. Moreover, we present the practical application of our sensorized soft gripper for remotely controlled cooking.

Multiscale crack trapping for programmable adhesives.

The precise control of crack propagation at bonded interfaces is crucial for smart adhesives with advanced performance. However, previous studies have primarily concentrated on either microscale or macroscale crack propagation. Here, we present a hybrid adhesive that integrates microarchitectures and macroscopic nonlinear cut architectures for unparalleled adhesion control. The integration of these architectural elements enables conformal attachment and simultaneous crack trapping across multiple scales for high capacity, enhancing adhesion by more than 70×, while facilitating crack propagation at the macroscale in specific directions for programmable release and reusability. As adhesion strength and directionality can be independently controlled at any location, skin adhesive patches are created that are breathable, nondamaging, and exceptionally strong and secure yet remove easily. These capabilities are demonstrated with a skin-mounted adhesive patch with integrated electronics that accurately detects human motion and wirelessly transmits signals, enabling real-time control of avatars in virtual reality applications.

Mussel-inspired resilient hydrogels with strong skin adhesion and high-sensitivity for wearable device.

Stretchable and self-adhesive conductive hydrogels hold significant importance across a wide spectrum of applications, including human-machine interfaces, wearable devices, and soft robotics. However, integrating multiple properties, such as high stretchability, strong interfacial adhesion, self-healing capability, and sensitivity, into a single material poses significant technical challenges. Herein, we present a multifunctional conductive hydrogel based on poly(acrylic acid) (PAA), dopamine-functionalized pectin (PT-DA), polydopamine-coated reduction graphene oxide (rGO-PDA), and Fe3+ as an ionic cross-linker. This hydrogel exhibits a combination of high stretchability (2000%), rapid self-healing (~ 94% recovery in 5 s), and robust self-adhesion to various substrates. Notably, the hydrogel demonstrates a remarkable skin adhesion strength of 85 kPa, surpassing previous skin adhesive hydrogels. Furthermore, incorporating rGO within the hydrogel network creates electric pathways, ensuring excellent conductivity (0.56 S m-1). Consequently, these conductive hydrogels exhibit strain-sensing properties with a significant increase in gauge factor (GF) of 14.6, covering an extensive detection range of ~ 1000%, fast response (198 ms) and exceptional cycle stability. These multifunctional hydrogels can be seamlessly integrated into motion detection sensors capable of distinguishing between various strong or subtle movements of the human body.

Multifunctional Magnetic Muscles for Soft Robotics.

Despite recent advancements, artificial muscles have not yet been able to strike the right balance between exceptional mechanical properties and dexterous actuation abilities that are found in biological systems. Here, we present an artificial magnetic muscle that exhibits multiple remarkable mechanical properties and demonstrates comprehensive actuating performance, surpassing those of biological muscles. This artificial muscle utilizes a composite configuration, integrating a phase-change polymer and ferromagnetic particles, enabling active control over mechanical properties and complex actuating motions through remote laser heating and magnetic field manipulation. Consequently, the magnetic composite muscle can dynamically adjust its stiffness as needed, achieving a switching ratio exceeding 2.7 × 10³. This remarkable adaptability facilitates substantial load-bearing capacity, with specific load capacities of up to 1000 and 3690 for tensile and compressive stresses, respectively. Moreover, it demonstrates reversible extension, contraction, bending, and twisting, with stretchability exceeding 800%. We leverage these distinctive attributes to showcase the versatility of this composite muscle as a soft continuum robotic manipulator. It adeptly executes various programmable responses and performs complex tasks while minimizing mechanical vibrations. Furthermore, we demonstrate that this composite muscle excels across multiple mechanical and actuation aspects compared to existing actuators.

Si/InGaN core/shell hierarchical nanowire arrays and their photoelectrochemical properties.

Three-dimensional hierarchical nanostructures were synthesized by the halide chemical vapor deposition of InGaN nanowires on Si wire arrays. Single phase InGaN nanowires grew vertically on the sidewalls of Si wires and acted as a high surface area photoanode for solar water splitting. Electrochemical measurements showed that the photocurrent density with hierarchical Si/InGaN nanowire arrays increased by 5 times compared to the photocurrent density with InGaN nanowire arrays grown on planar Si (1.23 V vs RHE). High-resolution transmission electron microscopy showed that InGaN nanowires are stable after 15 h of illumination. These measurements show that Si/InGaN hierarchical nanostructures are a viable high surface area electrode geometry for solar water splitting.