Detalhe da pesquisa
1.
Lessons from assembling a microbial natural product and pre-fractionated extract library in an academic laboratory.
J Ind Microbiol Biotechnol
; 50(1)2023 Feb 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-38052426
2.
Cyclobutanone Mimics of Intermediates in Metallo-ß-Lactamase Catalysis.
Chemistry
; 24(22): 5734-5737, 2018 Apr 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-29250863
3.
How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function.
Proc Natl Acad Sci U S A
; 110(42): 16808-13, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24085846
4.
Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-ß-thiophenylacrylamides exerts highly selective antifungal activity.
Cell Chem Biol
; 31(4): 760-775.e17, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38402621
5.
A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor.
Cell Rep
; 43(4): 114053, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38578824
6.
Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria.
ACS Infect Dis
; 8(10): 2187-2197, 2022 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36098580
7.
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity.
Cell Chem Biol
; 29(5): 840-853.e6, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34710358
8.
Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery.
ACS Med Chem Lett
; 13(2): 284-291, 2022 Feb 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35178184
9.
Hexafluoroisopropyl Sulfamate: A Useful Reagent for the Synthesis of Sulfamates and Sulfamides.
Org Lett
; 23(9): 3373-3378, 2021 05 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33861615
10.
Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane.
ACS Chem Biol
; 16(5): 929-942, 2021 05 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33974796
11.
Cyclobutanone analogues of beta-lactams revisited: insights into conformational requirements for inhibition of serine- and metallo-beta-lactamases.
J Am Chem Soc
; 132(8): 2558-60, 2010 Mar 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20141132
12.
A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium.
Nat Commun
; 10(1): 197, 2019 01 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-30643129
13.
Cyclobutanone mimics of penicillins: effects of substitution on conformation and hemiketal stability.
J Org Chem
; 73(18): 6970-82, 2008 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-18710291
14.
Evolving medicinal chemistry strategies in antibiotic discovery.
Curr Opin Biotechnol
; 42: 108-117, 2016 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-27116217
15.
Bacterial cell-wall recycling.
Ann N Y Acad Sci
; 1277: 54-75, 2013 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-23163477