RESUMO
A patient infected with human immunodeficiency virus developed a diffuse cutaneous nodular syndrome. The parasite isolated from a skin nodule was studied by isoenzymatic characterization and transmission electron microscopy of both culture forms and those in the patient's skin biopsy. The parasite's ultrastructure was that of a typical member of the family Trypanosomatidae, but it differed isoenzymatically from all 'new and 'old World' species of Leishmania, Trypanosoma and Sauroleishmania. We believe that it was a (presumably) monoxenous 'lower trypanosomatid.
Assuntos
Infecções Oportunistas Relacionadas com a AIDS/complicações , Infecções por Protozoários/complicações , Dermatopatias Parasitárias/complicações , Trypanosomatina/ultraestrutura , Infecções Oportunistas Relacionadas com a AIDS/patologia , Adulto , Animais , HIV-1 , Humanos , Masculino , Microscopia Eletrônica , Infecções por Protozoários/patologia , Pele/parasitologia , Pele/ultraestrutura , Dermatopatias Parasitárias/patologia , Trypanosomatina/classificaçãoAssuntos
Ectoparasitoses/parasitologia , Dermatoses Faciais/parasitologia , Trypanosomatina/isolamento & purificação , Animais , Ectoparasitoses/epidemiologia , Ectoparasitoses/imunologia , Dermatoses Faciais/epidemiologia , Dermatoses Faciais/imunologia , Humanos , Imunocompetência , Masculino , Martinica/epidemiologia , Pessoa de Meia-Idade , Trypanosomatina/imunologiaAssuntos
Amônia/análise , Tripsina/análise , Arginina , Autoanálise , Concentração de Íons de Hidrogênio , Cinética , Fotometria , TemperaturaAssuntos
Mordeduras e Picadas/microbiologia , Infecções por Pasteurella/microbiologia , Pasteurella/isolamento & purificação , Dermatopatias Bacterianas/microbiologia , Amoxicilina/uso terapêutico , Combinação Amoxicilina e Clavulanato de Potássio , Animais , Mordeduras e Picadas/tratamento farmacológico , Pré-Escolar , Ácidos Clavulânicos/uso terapêutico , Quimioterapia Combinada/uso terapêutico , Humanos , Masculino , Infecções por Pasteurella/tratamento farmacológico , Ratos , Dermatopatias Bacterianas/tratamento farmacológicoAssuntos
Bacteriemia/diagnóstico , Melioidose/diagnóstico , Idoso , Antibacterianos , Bacteriemia/tratamento farmacológico , Bacteriemia/microbiologia , Quimioterapia Combinada/uso terapêutico , Humanos , Masculino , Martinica , Melioidose/tratamento farmacológico , Melioidose/microbiologia , Sepse , SupuraçãoRESUMO
A case-control study was performed in Martinique, French West Indies, comparing 66 anti-p24 antibody carriers to 91 seronegative subjects for HTLV-I, matched for age and place of residence. The aim of our study was to identify factors associated with HTLV-I infection and to observe whether clinical examination and biological measurements would reveal any abnormalities among the seropositive subjects. We observed a predominance of females among seropositive subjects (74% compared to 59%, p less than 0.05), and a greater risk due to earlier blood transfusions (p less than 0.001). This survey revealed important differences between cases and controls regarding socioeconomic factors: cases had fewer luxuries or advantages (i.e. bathroom, toilets, refrigerator, telephone, p less than 0.01), were more corpulent (p less than 0.05), and more often widowed, divorced or separated (p less than 0.01) than the controls. Although the differences were not significant, the seropositive donors seemed to be less educated, and were from a lower socioprofessional class than the seronegative donors. With regard to clinical symptoms (infections, adenopathies, splenomegaly, hepatomegaly) and biological parameters (blood count; T-cell subsets, electrophoresis of protids, immunoglobulins, calcemia, antischistosomal antibody), seropositive subjects appeared to be healthy; no parameters, except for alpha 1 globulin (p less than 0.05) and monocytes (p less than 0.05), were found to be correlated with seropositivity; but these two parameters remained within their normal ranges. This study confirms blood transfusion as a risk factor. It underscored the importance of socioeconomic factors for seropositivity.