Detalhe da pesquisa
1.
Inhibition of SIRT7 overcomes sorafenib acquired resistance by suppressing ERK1/2 phosphorylation via the DDX3X-mediated NLRP3 inflammasome in hepatocellular carcinoma.
Drug Resist Updat
; 73: 101054, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38277756
2.
Endosulfine alpha maintains spindle pole integrity by recruiting Aurora A during mitosis.
BMC Cancer
; 23(1): 1263, 2023 Dec 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-38129815
3.
Discovery of BET specific bromodomain inhibitors with a novel scaffold.
Bioorg Med Chem
; 72: 116967, 2022 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36099719
4.
Crystal structures of human NSDHL and development of its novel inhibitor with the potential to suppress EGFR activity.
Cell Mol Life Sci
; 78(1): 207-225, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-32140747
5.
Synthesis and Structure-Activity Relationships of Aristoyagonine Derivatives as Brd4 Bromodomain Inhibitors with X-ray Co-Crystal Research.
Molecules
; 26(6)2021 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33802888
6.
Optimization of cyclic sulfamide derivatives as 11ß-hydroxysteroid dehydrogenase 1 inhibitors for the potential treatment of ischemic brain injury.
Bioorg Med Chem Lett
; 30(2): 126787, 2020 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31759849
7.
A Novel Way of Preventing Postoperative Pancreatic Fistula by Directly Injecting Profibrogenic Materials into the Pancreatic Parenchyma.
Int J Mol Sci
; 21(5)2020 Mar 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32143463
8.
Identification of a novel SIRT7 inhibitor as anticancer drug candidate.
Biochem Biophys Res Commun
; 508(2): 451-457, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30503501
9.
Efficacy and safety of a novel topical agent for gallstone dissolution: 2-methoxy-6-methylpyridine.
J Transl Med
; 17(1): 195, 2019 06 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31182117
10.
A natural compound, aristoyagonine, is identified as a potent bromodomain inhibitor by mid-throughput screening.
Biochem Biophys Res Commun
; 503(2): 882-887, 2018 09 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29928885
11.
MASTL inhibition promotes mitotic catastrophe through PP2A activation to inhibit cancer growth and radioresistance in breast cancer cells.
BMC Cancer
; 18(1): 716, 2018 Jul 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-29976159
12.
Direct interaction of menin leads to ubiquitin-proteasomal degradation of ß-catenin.
Biochem Biophys Res Commun
; 492(1): 128-134, 2017 10 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28782520
13.
Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 27(16): 3909-3914, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28666737
14.
Synthesis and biological evaluation of thiazole derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 27(23): 5213-5220, 2017 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29103971
15.
Small-molecule inhibitors of ERK-mediated immediate early gene expression and proliferation of melanoma cells expressing mutated BRaf.
Biochem J
; 467(3): 425-38, 2015 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25695333
16.
Synthesis and biological evaluation of thienopyrimidine derivatives as GPR119 agonists.
Bioorg Med Chem Lett
; 24(17): 4281-5, 2014 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25082125
17.
The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.
Mol Cancer
; 12(1): 42, 2013 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-23680104
18.
Pharmacophore identification of c-Myc inhibitor 10074-G5.
Bioorg Med Chem Lett
; 23(1): 370-4, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23177256
19.
Structural modifications of (Z)-3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione that improve selectivity for inhibiting the proliferation of melanoma cells containing active ERK signaling.
Org Biomol Chem
; 11(22): 3706-32, 2013 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-23624850
20.
Synthesis and structure-activity relationships of carboxylic acid derivatives of pyridoxal as P2X receptor antagonists.
Bioorg Med Chem
; 21(9): 2643-50, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23510563