RESUMO
We propose a description of nonequilibrium systems via a simple protocol that combines exchange-correlation potentials from density functional theory with self-energies of many-body perturbation theory. The approach, aimed to avoid double counting of interactions, is tested against exact results in Hubbard-type systems, with respect to interaction strength, perturbation speed and inhomogeneity, and system dimensionality and size. In many regimes, we find significant improvement over adiabatic time dependent density functional theory or second Born nonequilibrium Green's function approximations. We briefly discuss the reasons for the residual discrepancies, and directions for future work.
RESUMO
The worldwide increase of resistant S. pneumoniae is a growing clinical problem. In several countries, a more restrictive use of penicillin has been promoted in hope of slowing the rates of resistant pneumococci. However, the consequences of such an action on pneumococcal population dynamics are not fully understood. Thus, a network model was constructed to assess the impacts of penicillin consumption and between-strain competition on the spread of penicillin non-susceptible pneumococci. Model simulations suggest that the age distribution for carriage of penicillin non-susceptible pneumococci, in contrast to susceptible pneumococci, is affected by penicillin consumption. Furthermore, it appears extremely difficult to reduce the incidence of penicillin non-susceptible pneumococci by simply controlling penicillin consumption, assuming that reduced penicillin susceptibility does not confer a fitness cost for the organism. A more judicious use of penicillin together with control measures are in that case required to manage penicillin resistance in pneumococci.
Assuntos
Antibacterianos/farmacologia , Resistência às Penicilinas , Penicilinas/farmacologia , Penicilinas/uso terapêutico , Streptococcus pneumoniae/efeitos dos fármacos , Adolescente , Adulto , Antibacterianos/uso terapêutico , Criança , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Biológicos , Infecções Pneumocócicas/tratamento farmacológico , SuéciaRESUMO
BACKGROUND: Intensification of livestock production seen in many low- and middle-income countries is often believed to be associated with increased use of antimicrobials, and may hence contribute to the emergence of antimicrobial resistance. The aim of this study was to map antimicrobial use on small- (n = 25) and medium-scale (n = 27) pig farms in north-eastern Thailand, and to compare antimicrobial susceptibility of commensal Escherichia coli isolated from sows on these farms. METHODS: Information regarding pig husbandry and antimicrobial treatment regimens was obtained by the use of semi-structured questionnaires. Faecal samples were collected from three healthy sows at each farm, and Escherichia coli was cultured and analysed for antimicrobial susceptibility using the broth microdilution method. Multilevel regression models were used to compare antimicrobial susceptibility between isolates from small- and medium-scale farms. RESULTS: All farms included in the study administered antimicrobials to their sows. Small-scale farmers most commonly (64%) decided themselves when to give antimicrobials and the majority (60%) bought the medicines at the local store or pharmacy, whereas farmers on medium-scale farms always discussed antimicrobial treatment with a veterinarian. Medium-scale farms used a greater diversity of antimicrobials than small-scale farms and did also administer antimicrobials in feed to a higher extent. High levels of antimicrobial resistance to several critically important antimicrobials for human medicine (including ciprofloxacin, streptomycin and ampicillin) were found in isolates from both small- and medium-scale farms. Resistance levels were significantly (P < 0.05) higher in isolates from medium-scale farms for several of the antimicrobials tested, as well as the level of multidrug-resistance (P = 0.026). CONCLUSION: The routines regarding access and administration of antimicrobials differed between the small- and medium-scale farms. Although the level of antimicrobial resistance, as well as multidrug-resistance, was higher in isolates from medium-scale farms, it cannot be concluded if this increase is a consequence of a more abundant use of antimicrobials, or a result of differences in administration routines.
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The effect of retrofitting an existing pond on removal efficiency and hydraulic performance was modelled using the commercial software Mike21 and compartmental modelling. The Mike21 model had previously been calibrated on the studied pond. Installation of baffles, the addition of culverts under a causeway and removal of an existing island were all studied as possible improvement measures in the pond. The subsequent effect on hydraulic performance and removal of suspended solids was then evaluated. Copper, cadmium, BOD, nitrogen and phosphorus removal were also investigated for that specific improvement measure showing the best results. Outcomes of this study reveal that all measures increase the removal efficiency of suspended solids. The hydraulic efficiency is improved for all cases, except for the case where the island is removed. Compartmental modelling was also used to evaluate hydraulic performance and facilitated a better understanding of the way each of the different measures affected the flow pattern and performance. It was concluded that the installation of baffles is the best of the studied measures resulting in a reduction in the annual load on the receiving lake by approximately 8,000 kg of suspended solids (25% reduction of the annual load), 2 kg of copper (10% reduction of the annual load) and 600 kg of BOD (10% reduction of the annual load).
Assuntos
Modelos Teóricos , Eliminação de Resíduos Líquidos/métodos , Oxigênio/metabolismo , Chuva , Software , Movimentos da Água , Poluentes da Água/análise , Abastecimento de ÁguaRESUMO
Estimations of shoulder muscle load are important in biomechanic and ergonomic research. We have studied shoulder muscle load in the trapezius (six subjects), deltoid (six subjects), infraspinatus (eight subjects), and supraspinatus (seven subjects) muscles with simultaneous intramuscular pressure (IMP) and intramuscular bipolar electromyography (EMG) recordings. For imposition of shoulder muscle load, the arm was positioned in abduction or flexion with different hand loads (0, 1, or 2 kg), or isometric force registrations were performed. The microcapillary infusion technique was used for IMP recordings. The IMP in the supra- and infraspinatus muscles were high compared with the trapezius and deltoid muscles in abducted arm positions. In all test situations, IMP and EMG gave a similar description of local muscle load. IMP at maximal voluntary contraction was highest in the supraspinatus and infraspinatus muscles. Both IMP and EMG in all four muscles showed an almost linear correlation to recorded isometric external force. The difference in IMP between shoulder muscles in the same arm position may be due to muscle anatomy, muscle function, and compliance of surrounding tissues. Because a high IMP may impede muscle blood flow, our findings may possibly explain the physiological stress on the rotator cuff muscles as compared with the deltoid and trapezius muscles in work with elevated arms.
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Músculos/fisiologia , Ombro/fisiologia , Fenômenos Biomecânicos , Eletromiografia , Humanos , Contração Muscular , PressãoRESUMO
In this paper the concept of a three-dimensional biomechanical model of the human shoulder is introduced. This model is used to analyze static load sharing between the muscles, the bones and the ligaments. The model consists of all shoulder structures, which means that different positions and different load situations may be analyzed using the same model. Solutions can be found for the complete range of shoulder motion. However, this article focuses only on elevation in the scapular plane and on forces in structures attached to the humerus. The intention is to expand the model in future studies to also involve the forces acting on the other shoulder bones: the scapula and the clavicle. The musculoskeletal forces in the shoulder complex are predicted utilizing the optimization technique with the sum of squared muscle stresses as an objective function. Numerical results predict that among the muscles crossing the glenohumeral joint parts of the deltoideus, the infraspinatus, the supraspinatus, the subscapularis, the pectoralis major, the coracobrachialis and the biceps are the muscles most activated during this sort of abduction. Muscle-force levels reached values of 150 N when the hand load was 1 kg. The results from the model seem to be qualitatively accurate, but it is concluded that in the future development of the model the direction of the contact force in the glenohumeral joint must be constrained.
Assuntos
Modelos Biológicos , Ombro/fisiologia , Braço/fisiologia , Fenômenos Biomecânicos , Clavícula/fisiologia , Humanos , Úmero/fisiologia , Movimento , Músculos/fisiologia , Músculos Peitorais/fisiologia , Amplitude de Movimento Articular/fisiologia , Escápula/fisiologia , Articulação do Ombro/fisiologia , Estresse MecânicoRESUMO
A three-dimensional biomechanical model of the shoulder is developed for force predictions in 46 shoulder structures. The model is directed towards the analysis of static working situations where the load is low or moderate. Arbitrary static arm postures in the natural shoulder range may be considered, as well as different kinds of external loads including different force and moment directions. The model can predict internal forces for the shoulder muscles, for the glenohumeral, the acromioclavicular and the sternoclavicular joint as well as for the coracohumeral ligament. A solution to the statistically indeterminate force system is obtained by minimising an objective function. The default function chosen for this is the sum of the squared muscle stresses, but other objective functions may be used as well. The structure of the model is described and its ingredients discussed. The internal consistency of the model, its structural stability and the compatibility of the elements that go into it, is investigated.
Assuntos
Modelos Estruturais , Ombro/anatomia & histologia , Ombro/fisiologia , Articulação Acromioclavicular/fisiologia , Braço/anatomia & histologia , Braço/fisiologia , Fenômenos Biomecânicos , Previsões , Humanos , Úmero/fisiologia , Ligamentos Articulares/fisiologia , Movimento , Músculo Esquelético/fisiologia , Postura , Rotação , Escápula/fisiologia , Articulação do Ombro/fisiologia , Articulação Esternoclavicular/fisiologia , Estresse Mecânico , Tórax/anatomia & histologia , TrabalhoRESUMO
There is an obvious need for geographic distribution of expert knowledge among several health care units without increasing the cost of on-site expertise in locations where health care is provided. This paper describes the design of a knowledge-based decision-support system for extended consultation in clinical medicine. The system is based on Arden Syntax for Medical Logic Modules and hypertext using World Wide Web technology. It provides advice and explanations regarding the given advice. The explanations are presented in a hypertext format allowing the user to browse related information and to verify the relevance of the given advice. The system is intended to be used in a closed local network. With special precautions regarding issues of safety and patient security, the system can be used over wider areas such as in rural medicine. A prototype has been developed in the field of clinical microbiology and infectious diseases regarding infective endocarditis.
Assuntos
Inteligência Artificial , Redes de Comunicação de Computadores , Hipermídia , Consulta Remota , Processamento de Linguagem NaturalRESUMO
OBJECTIVE: The aim of the present work is to investigate the segmental movement patterns of the spine during normal treadmill gait. DESIGN: The spine movement during treadmill gait of ten healthy subjects (five men and five women) has been investigated using an optoelectronic measuring system. METHODS: The spine was divided into seven segments, from C(7) to S(2). The subjects walked with their normal speed. All data were normalized to per cent of the gait cycle. The normal patterns of the spine segment movements were found in the sagittal and the frontal planes. RESULTS: The behaviour of the spine can be described as the motion of a stiff element with superimposed small, inter-segmental movements. These small inter-segmental movements were found both in the sagittal and the frontal planes. CONCLUSIONS: The small inter-segmental movements could play an important role in the reduction of the energy consumption during gait and in maintenance of the equilibrium. RELEVANCE: Any disability affecting the spine should result in changing spine movement pattern during gait, thus changing the overall gait pattern. Therefore, treatment and rehabilitation should not discard the influence of the spine malfunctioning, regardless of its nature.
Assuntos
Movimento/fisiologia , Coluna Vertebral/fisiologia , Caminhada/fisiologia , Adulto , Feminino , Marcha/fisiologia , Articulação do Quadril/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Articulação do Ombro/fisiologiaRESUMO
Differences in expert and end-user contexts may be detrimental to the use of decision-support systems. A way to attend to this problem is to triangulate decision-support methods and information sources such as in the case of the expertext system model. To organize the information contained in the system, a common domain model is suggested as a instrument for annotating information. In this paper, a design and a prototype for a decision-support system in the field of urinary tract infections using techniques and methods developed in the GALEN projects is presented.
Assuntos
Indexação e Redação de Resumos , Sistemas de Apoio a Decisões Clínicas , Sistemas Inteligentes , Infecções Urinárias/terapia , Técnicas de Apoio para a Decisão , Humanos , Infecções Urinárias/diagnóstico , Vocabulário ControladoRESUMO
This paper describes problems identified in our attempts to develop an expert system for management of urinary tract infections. We found three aspects which we believe are important to consider when developing such systems. The objective of our future work will be to evaluate the impact of these problems on expert system development and usage.
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Inteligência Artificial , Sistemas Inteligentes , Sistemas de Apoio a Decisões Clínicas , Humanos , Infecções Urinárias/terapiaRESUMO
A Swedish data model for handling terminology, Spriterm, is presented in this paper. A prototype terminology management system, using the Spriterm data model in also described. This prototype is implemented is Microsoft ACCESS. Furthermore, two other applications using this prototype as a base are introduced. One World Wide Web based application, and a data dictionary.
Assuntos
Bases de Dados como Assunto , Terminologia como Assunto , Vocabulário Controlado , Internet , Suécia , Interface Usuário-ComputadorRESUMO
Non-equilibrium quantum phenomena are ubiquitous in nature. Yet, theoretical predictions on the real-time dynamics of many-body quantum systems remain formidably challenging, especially for high dimensions, strong interactions or disordered samples. Here we consider a notable paradigm of strongly correlated Fermi systems, the Mott phase of the Hubbard model, in a setup resembling ultracold-gases experiments. We study the three-dimensional expansion of a cloud into an optical lattice after removing the confining potential. We use time-dependent density-functional theory combined with dynamical mean-field theory, considering interactions below and above the Mott threshold, as well as disorder effects. At strong coupling, we observe multiple timescales in the melting of the Mott wedding-cake structure, as the Mott plateau persist orders of magnitude longer than the band insulating core. We also show that disorder destabilises the Mott plateau and that, compared to a clean setup, localisation can decrease, creating an interesting dynamic crossover during the expansion.
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A large number of investigations have been reported on minimising the PAH and PCDD/F yields during controlled combustion, such as incineration. This study is an attempt to quantify acute and chronic toxicants including PAH and PCDD/F in conditions relating to unwanted fires. This paper investigates distribution patterns of fire effluents between gas and aerosol phase, and the different particle size-ranges produced under different fire conditions. PVC carpet was selected as the fuel as a precursor for both PAH and PCDD/F. In order to generate fire effluents under controlled fire conditions, the steady-state tube furnace, was chosen as the physical fire model. Fire scenarios included oxidative pyrolysis, well-ventilated and under-ventilated fires. Fire effluent measurements included: carbon monoxide, carbon dioxide, hydrogen chloride, polycyclic aromatic hydrocarbons, chlorinated dibenzo-dioxins and furans and soot. The distribution patterns between gas and particle phase, and the size-ranges of the particles produced in these fires together with their chemical composition is also reported. Significant quantities of respirable submicron particles were detected, together with a range of PAHs. Lower levels of halogenated dioxins were detected in the fire residue compared with those found in other studies. Nevertheless, the findings do have implications for the health and safety of fire and rescue personnel, fire investigators, and other individuals exposed to the residue from unwanted fires.
Assuntos
Poluentes Atmosféricos/análise , Incêndios , Pisos e Cobertura de Pisos , Incineração , Cloreto de Polivinila/análise , Poluentes Atmosféricos/toxicidade , Poluição do Ar em Ambientes Fechados , Monitoramento Ambiental , Humanos , Dibenzodioxinas Policloradas/análogos & derivados , Hidrocarbonetos Policíclicos Aromáticos/análise , Cloreto de Polivinila/toxicidadeAssuntos
Glicolipídeos , Esfingolipídeos , Animais , Encéfalo , Bovinos , Cerebrosídeos , Fenômenos Químicos , Físico-Química , Cristalização , Galactose , Humanos , Membranas Artificiais , Modelos Estruturais , Esfingosina , Sulfoglicoesfingolipídeos , Água , Difração de Raios XAssuntos
Técnicas Bacteriológicas , Sistemas Computadorizados de Registros Médicos , Terminologia como Assunto , Infecções Urinárias/diagnóstico , Urina/microbiologia , Bacteriúria/diagnóstico , Bacteriúria/microbiologia , Humanos , Armazenamento e Recuperação da Informação , Atenção Primária à Saúde , Software , Suécia , Infecções Urinárias/microbiologiaRESUMO
Medical decision-support systems are of necessity multi-contextual in nature. There are always at least two contexts involved in the use of such systems: the expert knowledge-provider context and the end-user context. To show this, we present examples of context-dependent aspects significant to the use of decision-support systems. The existence of discrepancies between the contexts threatens to disrupt the rationale for using decision-support systems: for the system to transfer knowledge from the expert to the end-user. Both theoretical and empirical studies show that such discrepancies exist and that they may be detrimental to the use of decision-support systems. Systems must thus give support in interpreting the output produced by the system in the context of the end-user.
Assuntos
Técnicas de Apoio para a Decisão , Sistemas Inteligentes , Disseminação de Informação , Interface Usuário-Computador , Inteligência Artificial , Atitude do Pessoal de Saúde , Atitude Frente aos Computadores , Barreiras de Comunicação , Simulação por Computador , Conflito Psicológico , Sistemas Inteligentes/instrumentação , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Disseminação de Informação/métodos , Avaliação das Necessidades , Enquadramento Psicológico , Integração de SistemasRESUMO
In this study we present a concept system for the knowledge domain of urinary tract infections. The system was constructed using grounded theory methods, sampling from Swedish reference texts and patient records from consultations for urinary tract infections. The concept system is intended for use as an aid in the construction of a decision support system (DSS) for urinary tract infections, and as a search module in the mentioned DSS. In total 561 concepts were categorized in four major, and 58 subordinate categories. Relationships between the more important categories were developed, and the frequency of use of the most common concepts is presented. Using the presented categorical structure as domain model a prototype DSS for dipslide urine cultures has been developed.
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Formação de Conceito , Sistemas de Apoio a Decisões Clínicas , Infecções Urinárias/terapia , Teoria da Decisão , Humanos , Guias de Prática Clínica como Assunto , SuéciaRESUMO
House painters represent a group of construction workers with a high frequency of neck and shoulder complaints and concomitant high risks for early retirements. Shoulder tendinitis, especially supraspinatus tendinitis, occurs frequently among house painters. The tasks of sanding and painting of ceilings with extension handles are particularly strenuous for these body regions. The purpose of this study was to identify work techniques that would be less strenuous to the arms and shoulders during sanding work. A biomechanical model was applied to quantify the shoulder loads during sanding and to determine the likely muscle force distribution. The necessary input data were measured experimentally for the model by means of a load cell and strain gauges on an extension handle, a Kistler force plate, and a MacReflex motion analysis system. Forty experienced male painters participated in the study. Three different work techniques were identified: the normal technique, the reversed grip and the pushing technique. The pushing technique was characterized by shorter stroke length and lower speed of the grinding block than the other techniques. The painters among the group of subjects who used the pushing technique were found to report fewer shoulder disorders during sanding than the others. The most common shoulder tendinitis is the supraspinatus tendinitis, also among house painters, and using the Pushing technique could possibly prevent from this disorder. However, further research in larger groups of house painters is needed to be able to recommend this technique for a wider use.
Assuntos
Músculo Esquelético/lesões , Doenças Profissionais/fisiopatologia , Lesões do Ombro , Entorses e Distensões/fisiopatologia , Adulto , Fenômenos Biomecânicos , Arquitetura de Instituições de Saúde , Força da Mão , Humanos , Masculino , Modelos Biológicos , Pintura , Postura/fisiologia , Análise e Desempenho de Tarefas , Suporte de Carga/fisiologiaRESUMO
A method is presented for the determination of low molecular weight aliphatic isocyanates, methyl isocyanate (MIC), ethyl isocyanate (EIC), propyl isocyanate (PIC) and butyl isocyanate (BIC), as their dibutylamine (DBA) derivatives. The method is based on sampling in midget impinger flasks containing 10 ml of 0.01 mol l-1 DBA in toluene (as in Parts 1-4 in this series). The samples are analysed using liquid chromatography-electrospray mass spectrometry (LC-ESP-MS) or gas chromatography-mass spectrometry using chemical ionisation with ammonia, monitoring positive ions (GC-PCI). Quantification was effected by monitoring the molecular ions MH+. Aliquots of 10 ml of toluene solutions containing 0.01 mol l-1 DBA were spiked with 0.03-0.85 microgram of MIC-, EIC-, PIC- and BIC-DBA. The correlation coefficients for LC-ESP-MS were in the range 0.9952-0.9999 (n = 14). The repeatability (RSD) was in the range 0.37-1.2% (0.12-0.34 microgram ml-1, n = 10). The instrumental detection limit for MIC was about 15 micrograms l-1, which corresponds to about 0.5 microgram m-3 in a 15 l air sample. The correlation coefficients for GC-PCI were in the range 0.9913-0.9990. The repeatability (RSD) was in the range 1.1-4.9% (0.12-0.34 microgram ml-1, n = 10). The instrumental detection limit for MIC was about 0.2 microgram l-1, which corresponds to about 0.05 microgram m-3 in a 15 l air sample. Using electron ionisation, the instrumental detection limit for MIC was about 10 micrograms l-1. No derivatisation reaction losses were seen when the derivatization reaction between PIC and DBA took place in the presence of morpholine, propylamine, ethanol, phenol and water. When mineral wool with a phenol-formaldehyde-urea resin was thermally degraded, 0.1% m/m of MIC was released. In air samples taken on top of a new electric oven insulated with mineral wool, MIC was found in the range 0.1-3 mg m-3. No MIC in air was found from a pre-heated oven.