Detalhe da pesquisa
1.
A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.
Bioorg Med Chem
; 25(1): 381-388, 2017 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27840138
2.
Design and optimization of selective azaindole amide M1 positive allosteric modulators.
Bioorg Med Chem Lett
; 26(2): 650-655, 2016 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26631313
3.
Strategies toward optimization of the metabolism of a series of serotonin-4 partial agonists: investigation of azetidines as piperidine isosteres.
Xenobiotica
; 46(12): 1112-1121, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26947511
4.
Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.
Bioorg Med Chem Lett
; 25(4): 908-13, 2015 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25582600
5.
Interpretable, probability-based confidence metric for continuous quantitative structure-activity relationship models.
J Chem Inf Model
; 53(2): 368-83, 2013 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23343412
6.
Design and synthesis of dihydrobenzofuran amides as orally bioavailable, centrally active γ-secretase modulators.
Bioorg Med Chem Lett
; 22(8): 2906-11, 2012 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22429469
7.
Extraction of tacit knowledge from large ADME data sets via pairwise analysis.
Bioorg Med Chem
; 19(12): 3739-49, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21616672
8.
Correction to "Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry".
ACS Cent Sci
; 3(4): 359, 2017 Apr 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28470054
9.
Assessing Physicochemical Properties of Drug Molecules via Microsolvation Measurements with Differential Mobility Spectrometry.
ACS Cent Sci
; 3(2): 101-109, 2017 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-28280776
10.
Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.
Medchemcomm
; 8(4): 730-743, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108792
11.
Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability.
J Med Chem
; 59(11): 5284-96, 2016 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27228214
12.
Discovery of the Potent and Selective M1 PAM-Agonist N-[(3R,4S)-3-Hydroxytetrahydro-2H-pyran-4-yl]-5-methyl-4-[4-(1,3-thiazol-4-yl)benzyl]pyridine-2-carboxamide (PF-06767832): Evaluation of Efficacy and Cholinergic Side Effects.
J Med Chem
; 59(13): 6313-28, 2016 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-27275946
13.
Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.
ACS Med Chem Lett
; 6(5): 596-601, 2015 May 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26005540
14.
Design, synthesis, and pharmacological evaluation of a novel series of pyridopyrazine-1,6-dione γ-secretase modulators.
J Med Chem
; 57(3): 1046-62, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24428186
15.
Evaluating the differences in cycloalkyl ether metabolism using the design parameter "lipophilic metabolism efficiency" (LipMetE) and a matched molecular pairs analysis.
J Med Chem
; 56(17): 6985-90, 2013 Sep 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-23886251
16.
Novel γ-secretase modulators for the treatment of Alzheimer's disease: a review focusing on patents from 2010 to 2012.
Expert Opin Ther Pat
; 23(10): 1349-66, 2013 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-23875696
17.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
J Med Chem
; 55(7): 3414-24, 2012 Apr 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22420884
18.
Novel γ-secretase modulators: a review of patents from 2008 to 2010.
Expert Opin Ther Pat
; 21(2): 205-26, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21231889
19.
Design and discovery of a selective small molecule κ opioid antagonist (2-methyl-N-((2'-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine, PF-4455242).
J Med Chem
; 54(16): 5868-77, 2011 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-21744827
20.
Physicochemical features of the HERG channel drug binding site.
J Biol Chem
; 279(11): 10120-7, 2004 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-14699101