Detalhe da pesquisa
1.
Identification of azabenzimidazoles as potent JAK1 selective inhibitors.
Bioorg Med Chem Lett
; 26(1): 60-7, 2016 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26614408
2.
Integrated Proteomics Characterization of NLRP3 Inflammasome Inhibitor MCC950 in Monocytic Cell Line Confirms Direct MCC950 Engagement with Endogenous NLRP3.
ACS Chem Biol
; 19(4): 962-972, 2024 Apr 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38509779
3.
Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit.
ACS Chem Biol
; 18(2): 296-303, 2023 02 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36602435
4.
Discovery of Clinical Candidate AZD0095, a Selective Inhibitor of Monocarboxylate Transporter 4 (MCT4) for Oncology.
J Med Chem
; 66(1): 384-397, 2023 01 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36525250
5.
Direct activation of KCC2 arrests benzodiazepine refractory status epilepticus and limits the subsequent neuronal injury in mice.
Cell Rep Med
; 4(3): 100957, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36889319
6.
CETSA beyond Soluble Targets: a Broad Application to Multipass Transmembrane Proteins.
ACS Chem Biol
; 14(9): 1913-1920, 2019 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-31329413
7.
Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
J Med Chem
; 61(12): 5235-5244, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856615
8.
Development of a Novel B-Cell Lymphoma 6 (BCL6) PROTAC To Provide Insight into Small Molecule Targeting of BCL6.
ACS Chem Biol
; 13(11): 3131-3141, 2018 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30335946
9.
Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2.
ChemMedChem
; 12(12): 917-924, 2017 06 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-28371485