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2.
Zh Mikrobiol Epidemiol Immunobiol ; Suppl 2: 78-80, 1995.
Artigo em Russo | MEDLINE | ID: mdl-7771153

RESUMO

The study of the properties of V. cholerae strains isolated in June-September 1994 in the Daghestan revealed that they belonged, according to their specific properties, to typical representatives of V. eltor, serovar Ogawa, but a great part of them (67.2%) was not lysed by diagnostic cholera bacteriophages. Experiments with different batches of diagnostic cholera bacteriophages showed the necessity of their further improvement.


Assuntos
Tipagem de Bacteriófagos , Vibrio cholerae/classificação , Tipagem de Bacteriófagos/métodos , Cólera/microbiologia , Daguestão , Humanos , Preservação Biológica , Fatores de Tempo , Vibrio cholerae/isolamento & purificação
3.
Artigo em Russo | MEDLINE | ID: mdl-8067145

RESUMO

The reactogenicity and immunological effectiveness of different doses of cholera vaccine for oral administration (in tablets), containing choleragen toxoid, Ogawa and Inaba O-antigens and some of Vibrio cholerae exoenzymes, have been tested on 143 children aged 2-17 years. In this investigation the optimum immunization doses of the preparation have been established: two tablets containing 100,000 binding units (BU) of the toxoid and 2,500 units of O-antigen for children 11-14 years; four tablets containing 200,000 BU of the toxoid and 5,000 units of O-antigen for adolescents aged 15-17 years. An essential advantage of the oral vaccine over vaccines intended for parenteral administration lies in its capacity for inducing the accumulation of secretory antibodies (coproantibodies) in practically all vaccinees.


Assuntos
Vacinas contra Cólera/administração & dosagem , Administração Oral , Adolescente , Anticorpos Antibacterianos/análise , Criança , Pré-Escolar , Vacinas contra Cólera/efeitos adversos , Vacinas contra Cólera/imunologia , Relação Dose-Resposta Imunológica , Fezes/química , Humanos , Segurança , Comprimidos , Fatores de Tempo , Vacinas Sintéticas/administração & dosagem , Vacinas Sintéticas/efeitos adversos , Vacinas Sintéticas/imunologia , Vibrio cholerae/imunologia
4.
Artigo em Russo | MEDLINE | ID: mdl-11550565

RESUMO

The comparative evaluation of the diagnostic value of new cholera eltor bacteriophages ctx+ and ctx-, as well as monophages X[symbol: see text]-3, 4, 5, demonstrated their high activity and specificity. Using of these bacteriophages epidemic potential of 95% Vibrio cholerae eltor strains ctx+ and 84.5% of V. cholerae eltor stains ctx- was determined. Commercial monophages X[symbol: see text]-3, 4, 5 were inferior to bacteriophages ctx+ and ctx- in their diagnostic value: only 55% of strains having gene ctxAB were found to be epidemically dangerous, i.e. 45% of strains capable of causing the disease were not detected. On the basis of the results obtained in this investigation cholera eltor bacteriophages ctx+ and ctx- were recommended for introduction into practical use, while further production of cholera diagnostic monophages X[symbol: see text]-3, 4, 5 was recommended to be stopped.


Assuntos
Vibrio cholerae/classificação , Tipagem de Bacteriófagos/métodos , Sensibilidade e Especificidade , Vibrio cholerae/patogenicidade
5.
Artigo em Russo | MEDLINE | ID: mdl-12043146

RESUMO

Data on emergent epidemiological analysis of the cholera outbreak in Kazan are presented. A version of the cholera focus emergence was confirmed, namely water route of transmission as a result of bathing in a water reservoir where sewage waters had penetrated. The outbreak had local and acute character. The complex of cholera control interventions aimed at localization and liquidation of the focus proved to be effective.


Assuntos
Cólera/prevenção & controle , Poluição da Água/prevenção & controle , Cólera/epidemiologia , Cólera/etiologia , Cólera/transmissão , Controle de Doenças Transmissíveis , Transmissão de Doença Infecciosa , Água Doce/microbiologia , Humanos , Incidência , Federação Russa , Saneamento/normas , Esgotos/efeitos adversos , Esgotos/microbiologia , Natação , Vibrio cholerae/isolamento & purificação
6.
Artigo em Russo | MEDLINE | ID: mdl-12043149

RESUMO

Information on V. cholerae eltor isolated in the focus of cholera in Kazan in 2001 at different periods of the outbreak is presented. The identity of strains isolated from patients, vibriocarriers and environmental objects, including their antibioticograms (sensitivity to cyprofloxacin and resistance to trimethoprim--sulfamethoxazole, streptomycin, furazolidone and nalidixic acid, which may be regarded as markers), is shown. Variable tandem repetitions in the DNA of 30 isolates strains of different origin have been determined. The results of this determination make it possible to classify all these strains as one genotype, which confirms the suggestion on the circulation of one subclone of the infective agent of cholera in the focus. As revealed in this investigation, the isolated strains are labile with respect to diagnostic phage eltor, while ctx+ strains are resistant to phage eltor ctx+.


Assuntos
Cólera/metabolismo , Vibrio cholerae/genética , Vibrio cholerae/metabolismo , Antibacterianos/metabolismo , Antibacterianos/uso terapêutico , Biomarcadores , Cólera/tratamento farmacológico , Cólera/epidemiologia , Ciprofloxacina/uso terapêutico , Resistência Microbiana a Medicamentos/genética , Furazolidona/metabolismo , Genótipo , Humanos , Ácido Nalidíxico/metabolismo , Federação Russa/epidemiologia , Estreptomicina/metabolismo , Sulfametoxazol/metabolismo , Resistência a Trimetoprima/genética , Vibrio cholerae/classificação , Vibrio cholerae/efeitos dos fármacos , Vibrio cholerae/isolamento & purificação
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