Detalhe da pesquisa
1.
PAI-1 Deficiency Drives Pulmonary Vascular Smooth Muscle Remodeling and Pulmonary Hypertension.
Am J Physiol Lung Cell Mol Physiol
; 2024 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38860847
2.
Automated Patch Clamp Screening of Amiloride and 5-N,N-Hexamethyleneamiloride Analogs Identifies 6-Iodoamiloride as a Potent Acid-Sensing Ion Channel Inhibitor.
Mol Pharm
; 20(7): 3367-3379, 2023 07 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37260417
3.
Systematic evaluation of structure-property relationships and pharmacokinetics in 6-(hetero)aryl-substituted matched pair analogs of amiloride and 5-(N,N-hexamethylene)amiloride.
Bioorg Med Chem
; 37: 116116, 2021 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33799173
4.
Screening of 5- and 6-Substituted Amiloride Libraries Identifies Dual-uPA/NHE1 Active and Single Target-Selective Inhibitors.
Int J Mol Sci
; 22(6)2021 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33804289
5.
Cephalosporin nitric oxide-donor prodrug DEA-C3D disperses biofilms formed by clinical cystic fibrosis isolates of Pseudomonas aeruginosa.
J Antimicrob Chemother
; 75(1): 117-125, 2020 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31682251
6.
Introduction of a Fixed-Charge, Photolabile Derivative for Enhanced Structural Elucidation of Fatty Acids.
Anal Chem
; 91(15): 9901-9909, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31298837
7.
Prototyping kinase inhibitor-cytotoxin anticancer mutual prodrugs activated by tumour hypoxia: A chemical proof of concept study.
Bioorg Med Chem Lett
; 29(10): 1215-1219, 2019 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30885680
8.
6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease.
Bioorg Med Chem Lett
; 29(24): 126753, 2019 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31679971
9.
Mass spectrometry-directed structure elucidation and total synthesis of ultra-long chain (O-acyl)-ω-hydroxy fatty acids.
J Lipid Res
; 59(8): 1510-1518, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29907595
10.
Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens.
J Struct Biol
; 204(3): 396-405, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30366028
11.
Attaching NorA efflux pump inhibitors to methylene blue enhances antimicrobial photodynamic inactivation of Escherichia coli and Acinetobacter baumannii in vitro and in vivo.
Bioorg Med Chem Lett
; 28(16): 2736-2740, 2018 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29519734
12.
Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin-resistant Staphylococcus aureus.
Bioorg Med Chem Lett
; 28(22): 3526-3528, 2018 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30297281
13.
Cephalosporin-3'-Diazeniumdiolate NO Donor Prodrug PYRRO-C3D Enhances Azithromycin Susceptibility of Nontypeable Haemophilus influenzae Biofilms.
Antimicrob Agents Chemother
; 61(2)2017 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27919896
14.
Primary ciliary dyskinesia ciliated airway cells show increased susceptibility to Haemophilus influenzae biofilm formation.
Eur Respir J
; 50(3)2017 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-28890436
15.
Cephalosporin-NO-donor prodrug PYRRO-C3D shows ß-lactam-mediated activity against Streptococcus pneumoniae biofilms.
Nitric Oxide
; 65: 43-49, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235635
16.
Determination of ester position in isomeric (O-acyl)-hydroxy fatty acids by ion trap mass spectrometry.
Rapid Commun Mass Spectrom
; 30(21): 2351-2359, 2016 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27520617
17.
Synthesis and preliminary evaluation of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones as angiogenesis inhibitors.
Bioorg Med Chem Lett
; 26(7): 1813-6, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26912111
18.
Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile.
Bioorg Med Chem Lett
; 25(22): 5203-7, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26459212
19.
On the Mechanism of Berberine-INF55 (5-Nitro-2-phenylindole) Hybrid Antibacterials.
Aust J Chem
; 67: 1471-1480, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-26806960
20.
Corrigendum to "Crystal structures and biochemical characterization of DNA sliding clamps from three Gram-negative bacterial pathogens" [J. Struct. Biol. 204 (3) (2018) 396-405].
J Struct Biol
; 207(2): 234, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31097372