Frequency dependence of sensitivity to interaural phase differences in pure tones.

It is well established that in normal-hearing humans, the threshold of interaural time differences for pure tones increases dramatically above about 1300 Hz, only to become unmeasurable above 1400 Hz. However, physiological data and auditory models suggest that the actual decline in sensitivity is more gradual and only appears to be abrupt because the maximum of the psychometric function dips below the threshold proportion correct, e.g., 0.794. Published data only report thresholds at certain proportions correct but not the decline of proportions correct or of the sensitivity index d' with increasing frequencies. Here, we present pure-tone behavioral data obtained with a constant stimulus procedure. Seven of nine subjects showed proportions correct above 0.9 at 1300 Hz and virtually no sensitivity at 1500 Hz (proportion correct within 0.07 of chance level). This corresponds to a sensitivity decline of 46-78 dB/oct, much steeper than predicted by existing models or by the decline of phase locking of the auditory nerve fibers in animal data.

Neural rate difference model can account for lateralization of high-frequency stimuli.

Lateralization of complex high-frequency sounds is conveyed by interaural level differences (ILDs) and interaural time differences (ITDs) in the envelope. In this work, the authors constructed an auditory model and simulate data from three previous behavioral studies obtained with, in total, over 1000 different amplitude-modulated stimuli. The authors combine a well-established auditory periphery model with a functional count-comparison model for binaural excitatory-inhibitory (EI) interaction. After parameter optimization of the EI-model stage, the hemispheric rate-difference between pairs of EI-model neurons relates linearly with the extent of laterality in human listeners. If a certain ILD and a certain envelope ITD each cause a similar extent of laterality, they also produce a similar rate difference in the same model neurons. After parameter optimization, the model accounts for 95.7% of the variance in the largest dataset, in which amplitude modulation depth, rate of modulation, modulation exponent, ILD, and envelope ITD were varied. The model also accounts for 83% of the variances in each of the other two datasets using the same EI model parameters.

Characterization of the decline in auditory nerve phase locking at high frequencies.

The frequency dependence of phase locking in the auditory nerve influences various auditory coding mechanisms. The decline of phase locking with increasing frequency is commonly described by a low-pass filter. This study compares fitted low-pass filter parameters with the actual rate of phase locking decline. The decline is similar across studies and only 40 dB per decade, corresponding to the asymptotic decline of a second order filter.

Simulation of ITD-Dependent Single-Neuron Responses Under Electrical Stimulation and with Amplitude-Modulated Acoustic Stimuli.

Interaural time difference (ITD) sensitivity with cochlear implant stimulation is remarkably similar to envelope ITD sensitivity using conventional acoustic stimulation. This holds true for human perception, as well as for neural response rates recorded in the inferior colliculus of several mammalian species. We hypothesize that robust excitatory-inhibitory (EI) interaction is the dominant mechanism. Therefore, we connected the same single EI-model neuron to either a model of the normal acoustic auditory periphery or to a model of the electrically stimulated auditory nerve. The model captured most features of the experimentally obtained response properties with electric stimulation, such as the shape of rate-ITD functions, the dependence on stimulation level, and the pulse rate or modulation-frequency dependence. Rate-ITD functions with high-rate, amplitude-modulated electric stimuli were very similar to their acoustic counterparts. Responses obtained with unmodulated electric pulse trains most resembled acoustic filtered clicks. The fairly rapid decline of ITD sensitivity at rates above 300 pulses or cycles per second is correctly simulated by the 3.1-ms time constant of the inhibitory post-synaptic conductance. As the model accounts for these basic properties, it is expected to help in understanding and quantifying the binaural hearing abilities with electric stimulation when integrated in bigger simulation frameworks.