Detalhe da pesquisa
1.
Clinical targeting of HIV capsid protein with a long-acting small molecule.
Nature
; 584(7822): 614-618, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32612233
2.
Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.
J Biol Chem
; 290(13): 8439-46, 2015 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-25631052
3.
Functional label-free assays for characterizing the in vitro mechanism of action of small molecule modulators of capsid assembly.
Biochemistry
; 54(13): 2240-8, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25774576
4.
A Probody T Cell-Engaging Bispecific Antibody Targeting EGFR and CD3 Inhibits Colon Cancer Growth with Limited Toxicity.
Cancer Res
; 82(22): 4288-4298, 2022 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-36112781
5.
Suppression of HDAC nuclear export and cardiomyocyte hypertrophy by novel irreversible inhibitors of CRM1.
Biochim Biophys Acta
; 1789(5): 422-31, 2009 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-19414071
6.
Discovery of an Atropisomeric PI3Kß Selective Inhibitor through Optimization of the Hinge Binding Motif.
ACS Med Chem Lett
; 11(6): 1236-1243, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551006
7.
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) ß Inhibitor.
J Med Chem
; 61(15): 6858-6868, 2018 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30015489
8.
Discovery of a Phosphoinositide 3-Kinase (PI3K) ß/δ Inhibitor for the Treatment of Phosphatase and Tensin Homolog (PTEN) Deficient Tumors: Building PI3Kß Potency in a PI3Kδ-Selective Template by Targeting Nonconserved Asp856.
J Med Chem
; 60(4): 1555-1567, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28106991
9.
Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability.
J Med Chem
; 59(19): 9228-9242, 2016 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27660855
10.
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors.
J Med Chem
; 59(7): 3532-48, 2016 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-26980109
11.
Optimized high-throughput screen for hepatitis C virus translation inhibitors.
J Biomol Screen
; 16(2): 211-20, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21297107
12.
Screening and identification of a novel class of TGF-ß type 1 receptor kinase inhibitor.
J Biomol Screen
; 16(7): 724-33, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21521800