Phonon Topology and Winding of Spectral Weight in Graphite.

The topology of electronic and phonon band structures of graphene is well studied and known to exhibit a Dirac cone at the K point of the Brillouin zone. Here, we applied inelastic x-ray scattering (IXS) along with ab initio calculations to investigate phonon topology in graphite, the 3D analog of graphene. We identified a pair of modes that form a very weakly gapped linear anticrossing at the K point that can be essentially viewed as a Dirac cone approximant. The IXS intensity in the vicinity of the quasi-Dirac point reveals a harmonic modulation of the phonon spectral weight above and below the Dirac energy, which was previously proposed as an experimental fingerprint of the nontrivial topology. We illustrate how the topological winding of IXS intensity can be understood in terms of atomic displacements and highlight that the intensity winding is not in fact sensitive in telling quasi- and true Dirac points apart.

[Social representation of persons with disabilities in marketing and advertising practice].

The article discusses the issues of including the image of persons with disabilities in marketing and advertising practice. The data reflecting the statistics of disability and consumer behavior in the market of goods and services for the disabled and persons with disabilities are presented. The purpose of the study is to analyze the current practice of marketing and advertising activities using the image of disability and persons with disabilities. It is concluded that both advertising and any other forms of marketing initiatives reflect society, and therefore most advertisers at some point create communication products that somehow reflect their target audience. Good examples of images of people with disabilities and a well-thought-out advertising campaign are designed to increase brand loyalty and at the same time make the product more popular with a wide audience.

[General ideas about the stages, classifications, pathological conditions during the lower third molars eruption in humans. Literature review. Part 1]. / Obshchie predstavleniya o stadiyakh, klassifikatsiyakh, patologicheskikh sostoyaniyakh pri prorezyvanii nizhnikh tret'ikh molyarov u cheloveka. Obzor literatury. Chast' 1.

The article is a review of literature data on the stages, classifications, pathological conditions during the eruption of the lower third molars in humans. The authors analyzed the established knowledge about clinical and morphological changes at various stages of eruption of the lower third molars, studied new data describing the pathogenetic, histological and biochemical features of their development, packaging, movement to the occlusal plane. The literature review helped to identify a series of current trends that define a number of key hypotheses that summarize the accumulated material and indicate different opinions on the topic under study, which confirms the prospects and relevance of continuing research.

[General ideas about the stages, classifications, pathological conditions during the lower third molars eruption in humans. Literature review. Part 2]. / Obshchie predstavleniya o stadiyakh, klassifikatsiyakh, patologicheskikh sostoyaniyakh pri prorezyvanii nizhnikh tret'ikh molyarov u cheloveka. Obzor literatury. Chast' 2.

The article is a review of literature data on the stages, classifications, pathological conditions during the eruption of the lower third molars in humans. The authors analyzed the established knowledge about clinical and morphological changes at various stages of eruption of the lower third molars, studied new data describing the pathogenetic, histological and biochemical features of their development, packaging, movement to the occlusal plane. The literature review helped to identify a series of current trends that define a number of key hypotheses that summarize the accumulated material and indicate different opinions on the topic under study, which confirms the prospects and relevance of continuing research.

[ORGANIZATIONAL AND MANAGERIAL ASPECTS OF THE DEVELOPMENT OF PROJECTS IN THE FIELD OF MEDICAL CHARITY].

The article deals with organizational and managerial problems of projects in the field of medical charity. The development of the sector of non-profit organizations in the medical field today is due to the fact that the effective activity of the state is ensured by the stable development of the social sphere. The importance of charitable projects in the field of medicine is one of the important resources aimed at increasing the availability of medical care to needy categories of citizens around the world. Accessibility of medical care is achieved due to a complex of factors, among which a significant role is given to the capabilities of medical organizations themselves. Due to the fact that financial support has its limitations, charitable projects in the medical field become a resource that allows you to regulate the availability of medical care. The activities of charitable organizations in the medical field in modern conditions require the involvement of significant resources and the formation of an organizational and managerial mechanism for the development of projects in the field of assistance to those in need. The analysis of organizational and managerial aspects of the development of projects in the field of medical charity and the development of proposals for improving the activities of charitable organizations are the purpose of this work.

[THE DEVELOPMENT OF TELEMEDICINE TECHNOLOGIES AND THE ATTITUDE OF SENIOR CITIZENS TO THEIR USE].

The purpose of the study presented in this paper is to consider the attitude of senior citizens (aged 65 years and older) to telemedicine technologies and their readiness to use them.Telemedicine has become widespread in recent years, and its use will expand in the near future. Telemedicine technologies have proved to be an effective tool for solving a number of problems: providing access to medical consultations, prompt response of medical workers to patient requests, monitoring of health indicators, etc. However, the prevalence of the use of these technologies is differentiated in different age groups. Due to the fact that elderly citizens are not active users of digital gadgets, the introduction of telemedicine technologies into their daily practice of taking care of their own health is in many ways difficult.

[The nature of metabolic processes in human dental hard tissues depending on their morphological structure]. / Kharakter obmennykh protsessov v tverdykh tkanyakh zubov cheloveka v zavisimosti ot ikh morfologicheskogo stroeniya.

THE STUDY OBJECTIVE: Was to give a comparative assessment of the movement of enamel and dentin fluid depending on the morphological structure of different sections of human dental hard tissues. MATERIALS AND METHODS: The research involved 140 female subjects aged 21-30 years. Sizes, form, surface of enamel-dentin junction, enamel prisms and their crystals in superficial, middle and deep sections, width, tortuosity, facing of dentin tubules of tested teeth were analyzed by scanning electron microscope Jeol JCM-5700 and atomic force microscope NTEGRA Prima. The biochemical study examined the quantitative content of water in the samples of enamel, dentin, enamel-dentin junction by weighing sample weights before and after drying. The data obtained were processed by methods of variation statistics using standard packages Microsoft Excel 2008, Statistica 12.0. RESULTS: The enamel-dentine junction of large-fastened type is characterized by zones of dentin integration into enamel at the distance of more than 10 mm, with regular arrangement of enamel prisms and wide dentine tubules of 3.55 to 4.70 µm in diameter; no water content reduction was found. The small-fastened type has less pronounced spots of dentin interference with enamel from 2 to 10 µm, the dentinal tubules are slightly curved with a diameter of 2.90 to 3.60 µm, the water content in dentin is reduced. In microfastened type, a linear structure with interpenetration zones up to 2 µm, enamel prisms slightly ordered, dentin tubules narrowed and curved in diameter from 1.30 to 1.95 µm, water content in enamel and dentin is reduced. CONCLUSION: At microfastened type of enamel-dentin junction, chaotic arrangement of enamel prisms and narrow dentin tubules water movement is broken and metabolic processes are reduced that determines high probability of exposure of dental hard tissue diseases.

[Combined cerebral revascularization for moyamoya disease]. / Kombinirovannaya revaskulyarizatsiya golovnogo mozga v lechenii bolezni moiya-moiya.

INTRODUCTION: Combined cerebral revascularization with direct and indirect components is recognized as the most appropriate method for treating patients with Moyamoya disease all over the world, however, large studies on its effectiveness in Russia have not yet been conducted. THE AIM OF THE STUDY: Was to evaluate the results of combined cerebral revascularization in patients with Moyamoya disease with an analysis of the clinical state and perfusion and angiographic features of neoangiogenesis. MATERIAL AND METHODS: For the period from 2013 to 2020 in N.N. Burdenko National Medical Research Center of Neurosurgery 79 combined revascularizations were performed in 55 patients with Moyamoya disease. The average age was 13.9±10.11 years. All patients were examined according to a single protocol, including a comprehensive assessment of the clinical symptoms, the state of the brain tissue, the cerebral vascular system, and cerebral blood flow. The results of surgical treatment were evaluated in the early postoperative and long-term periods. The average follow-up period was 14.66±13.17 months. In the postoperative period, the dynamics of neurological status and cerebral blood flow were assessed and the features of neoangiogenesis from various components of revascularization were studied. RESULTS: In the early postoperative period, in 77.2% of cases, a good treatment result was observed, with no negative dynamics of the neurological status. Ischemic stroke in the operated hemisphere developed in 4 cases (5.1%). In the follow-up period, an improvement in neurological symptoms was observed in 76.6%. Improvement of cerebral blood flow was noted in 92.4% of cases, direct anastomoses functioned in 94.3%, and signs of neovascularization in the area of indirect synangiosis were observed in 80.0%. At the same time, a complementary influence of direct and indirect components of revascularization was revealed in ensuring good general angiographic and perfusion results. CONCLUSIONS: Combined revascularization is a highly effective method of surgical treatment of all patients with Moyamoya disease.

[Ischemic complications following surgical treatment of moyamoya disease: risk factors and prevention]. / Ishemicheskie oslozhneniya khirurgicheskogo lecheniya patsientov s bolezn'yu moiya-moiya: faktory riska i metody profilaktiki.

BACKGROUND: One of the most difficult problems in surgical treatment of moyamoya disease is prevention of ischemic perioperative complications. The risk of these events is significantly higher compared to other cerebrovascular diseases (up to 30%). OBJECTIVE: To identify unfavorable prognostic factors of perioperative cerebral ischemic complications, to determine the group of high-risk patients and to develop the guidelines for perioperative management of these patients. MATERIAL AND METHODS: We analyzed clinical and diagnostic data and postoperative outcomes in 80 patients with various forms of moyamoya disease. These patients underwent 134 different interventions. Staged revascularization of both hemispheres was performed in 40 patients (80 surgeries). Most patients (n = 55) underwent combined brain revascularization (79 surgeries). RESULTS: Persistent postoperative complications (ischemic stroke) developed in 7 cases (5.3%). Transient neurological impairment was observed in 36 cases (27%). Statistical analysis revealed the following risk factors of perioperative complications: critical stenosis/occlusion of posterior cerebral artery (OR 9.704), severe perfusion deficit (OR 5.393) and previous TIA or ischemic stroke within 3 months prior to surgery (OR 6.433). If at least two of these signs are present, sensitivity of prognosis for postoperative complications is 80.7% and 88.6%, respectively. CONCLUSION: Patients with moyamoya disease are at high risk of perioperative complications due to complex rearrangement of collateral cerebral circulation and high sensitivity of brain to local and systemic hemodynamic changes. Patients with risk factors require careful perioperative management to exclude pathogenetic factors provoking ischemia. Early surgical treatment is advisable to reduce the risk of ischemic and hemorrhagic lesions following natural course of disease and severe perioperative complications.

[PUBLIC MANAGEMENT DURING THE THREAT OF THE SPREAD OF COVID-19].

The article is devoted to the research of problems and tasks of state management under the conditions of threat of spread of coronavirus infection COVID-19 and consideration of approaches to optimization of processes in the system of state management. The social and economic risks of the pandemic are identified and the directions of anti-crisis measures are considered. Public administration is a system consisting of citizens, business structures and government employees. State authorities, while implementing the directions of public policy, must take into account the interests of all participants of the system, building the channels of interaction between them in the most effective way. The pandemic is a serious challenge to the state administration system of any country, the prevention of the consequences of which requires timely and effective measures to be taken. Under the conditions of the pandemic in Russia, as well as all over the world, the role of the state has significantly increased, both in terms of prevention of pandemic spread, and in the form of measures aimed at supporting citizens and businesses, the most affected spheres of the economy. The purpose of this work is to consider new approaches to optimize the processes in the system of public administration, caused by the need to revise the directions of state policy under the threat of the spread of COVID-19.

[Objective evaluation of the caries prevention efficiency]. / Ob"ektivnaya otsenka effektivnosti kariesprofilakticheskikh sredstv.

BACKGROUND: The aim of the study was to test caries preventive gel compositions by a developed and patented objective laboratory method for evaluating the effectiveness of prophylactic agents based on the active transport of ions through tooth enamel. MATERIAL AND METHODS: The experiment used a prototype device for assessing ion transport and pork fangs filled with saline solution and immersed in various caries preventive media. An electric current was passed through the device and then the internal solution was analyzed in laboratory conditions for the concentration of ions in it. RESULTS: Minimal fluoride concentration (F≤500 ppm) with optimal concentration of calcium and phosphate ions does not impair ion transport to deep layers of enamel thus promoting active remineralization of dental hard tissues. CONCLUSION: During the experiment, the most active and promising gel-based caries preventive compositions were established, and a method for evaluating the effectiveness of prophylactic agents was proposed.

[Study of the human enamel prisms maturation nature in different periods of postpartum ontogenesis by atomic force microscopy]. / Izuchenie kharaktera sozrevaniya emalevykh prizm cheloveka v razlichnye periody postnatal'nogo ontogeneza metodom atomno-silovoi mikroskopii.

OBJECTIVE: It is necessary to study the human enamel prisms size at different periods of postpartum ontogenesis by atomic force microscopy. MATERIAL AND METHODS: The study involved 94 males which were divided into groups by age: 15-20, 21-30, 31-40, 41-50, 51-60 years old, each examined male had one 3.8 or 4.8 tooth removed (from the fracture line in the region angle of the mandible, according to orthodontic indications) for medical reasons. The shape, roughness, length and width of the enamel prisms were studied in the Image Analysis NT-VDT program according to the method of Omsk State Medical University. RESULTS: The enamel prisms structure at all ages has a regular, ordered shape with 6-sided and 7-sided figures. The most constant structure occurs at the age group of 41-50, 51-60 years. The fastest enamel prisms growth occurs in the direction that increases the prism length at all ages. Growth on a plane which increases the prism width is slow at 41-50 years. It is catching up with the growth rate of enamel prisms in length at 51-60 years old. Enamel prisms at 15-20, 21-30 years old stretch faster in the horizontal direction. CONCLUSION: In maturation process, due to correct and harmonious growth, enamel prisms are timely modified from pyramidal form in the early postpartum period to a prismatic form in the late postpartum period of ontogenesis.

[The research of the connective tissue dysplasia effect on dental eruption and hard tissues mineralization]. / Vliyanie displazii soedinitel'noi tkani na sroki prorezyvaniya i stepen' mineralizatsii zubov cheloveka.

OBJECTIVE: The purpose of this investigation was to explore the quality of 38, 48 teeth's hard tissues at different eruption stages and mandibular bone in different postpartum ontogenesis periods. MATERIAL AND METHODS: The research involved 102 male patients divided into groups according to their age: 15-20, 21-30 years old, they were extracted one tooth 38, 48 without inflammatory process signs and a fragment of the mandibular bone alveolar part in the projection of the teeth 38, 48 for orthodontic indications. In the comparison group (49 observations without signs of connective tissue dysplasia), in the study group (53 observations with signs of connective tissue dysplasia) we extracted teeth 38, 48 which were in the bone tissue. We analyzed condition of crown and root systems of extracted 38, 48 teeth, densitometric density of mineral component, size of enamel prisms, size of prismatic shells of organic matrix, spatial organization of collagen fibers in bone tissue, size characteristics of bone plates and mineralization centers of bone tissue. Processing of the obtained data was performed by methods of variation statistics using standard packages Microsoft Excel 2008, Statistica 12.0. RESULTS: The paper reveals one of the surgical dentistry pressing issues related to the tething mechanism of lower human wisdom teeth, considered by the authors from the position of tissue disorders in collagen type 1 observed in connective tissue dysplasia. At age of 15-20 years in connective tissue dysplasia, the enamel prisms hypomineralized areas are generalized; at age of 21-30 years the hypomineralized areas are characterized by local changes. At the age of 15-20 years in connective tissue dysplasia the bone plates splitting is observed at the level of most fibrils, collagen fibers have insufficiently oriented direction in contrast to the age group of 21-30 years where bone plates splitting is characteristic for single fibrils and collagen fibrils are clearly oriented. CONCLUSION: Morphological and histological changes in teeth 38, 48 and in bone tissue prevent correct and timely teething at 15-20 years and create more favorable conditions for teething at 21-30 years with a slower rate in connective tissue dysplasia, but in both groups teeth eruption occurs under unfavorable anatomic conditions.

Diffuse glioneuronal tumour with oligodendroglioma-like features and nuclear clusters (DGONC) - a molecularly defined glioneuronal CNS tumour class displaying recurrent monosomy 14.

AIMS: DNA methylation-based central nervous system (CNS) tumour classification has identified numerous molecularly distinct tumour types, and clinically relevant subgroups among known CNS tumour entities that were previously thought to represent homogeneous diseases. Our study aimed at characterizing a novel, molecularly defined variant of glioneuronal CNS tumour. PATIENTS AND METHODS: DNA methylation profiling was performed using the Infinium MethylationEPIC or 450 k BeadChip arrays (Illumina) and analysed using the 'conumee' package in R computing environment. Additional gene panel sequencing was also performed. Tumour samples were collected at the German Cancer Research Centre (DKFZ) and provided by multinational collaborators. Histological sections were also collected and independently reviewed. RESULTS: Genome-wide DNA methylation data from >25 000 CNS tumours were screened for clusters separated from established DNA methylation classes, revealing a novel group comprising 31 tumours, mainly found in paediatric patients. This DNA methylation-defined variant of low-grade CNS tumours with glioneuronal differentiation displays recurrent monosomy 14, nuclear clusters within a morphology that is otherwise reminiscent of oligodendroglioma and other established entities with clear cell histology, and a lack of genetic alterations commonly observed in other (paediatric) glioneuronal entities. CONCLUSIONS: DNA methylation-based tumour classification is an objective method of assessing tumour origins, which may aid in diagnosis, especially for atypical cases. With increasing sample size, methylation analysis allows for the identification of rare, putative new tumour entities, which are currently not recognized by the WHO classification. Our study revealed the existence of a DNA methylation-defined class of low-grade glioneuronal tumours with recurrent monosomy 14, oligodendroglioma-like features and nuclear clusters.

[Discussion of the manuscript Combined double-barrel direct and indirect bilateral cerebral revascularization in the treatment of moyamoya disease. Discussion and literature review]. / K obsuzhdeniyu stat'i «Sochetanie kombinirovannoi dvustvol'noi pryamoi i nepryamoi revaskulyarizatsii golovnogo mozga s dvukh storon v lechenii bolezni moyamoya¼. Diskussiya i obzor literatury.

First of all, I would like to thank my colleagues for their interest in this article [1] and note the relevance of the problem of surgical treatment of moyamoya disease, which provoked this discussion. Moyamoya disease is a rare, atypical pathology for our country, the diagnosis and treatment of which is controversial among specialists, and the lack of agreed protocols is the cause of differences in the interpretation of the results of surgical treatment of such patients.

[Combination of double and indirect two-sided revascularization of the brain in the treatment of moyamoya disease]. / Sochetanie kombinirovannoi dvustvol'noi pryamoi i nepryamoi revaskulyarizatsii golovnogo mozga s dvukh storon v lechenii bolezni moyamoya.

An adult patient with progressive chronic cerebral ischemia associated with moyamoya disease who underwent combined revascularization of both cerebral hemispheres in step-by-step fashion is reported in the article. The feature of this case is a large volume of revascularization procedures with double-barrel extra-intracranial anastomoses combined with indirect synangioses. This surgical approach ensured early postoperative development of extensive collateral network and complete compensation of impaired cerebral circulation. Particular attention is paid to description and discussion of preoperative diagnosis, the choice of surgical treatment, as well as the features of surgical technique. The advantages and disadvantages of this approach are discussed in comparison with literature data.

[Modern trends in diagnosis and surgical treatment of moyamoya disease]. / Sovremennye tendentsii diagnostiki i khirurgicheskogo lecheniya bolezni moiyamoiya.

This review is devoted to moyamoya disease. It is a rare chronic steno-occlusive cerebrovascular disease. However, moyamoya disease is increasingly diagnosed by neurosurgeons in our country. Unlike atherosclerotic lesions of cerebral arteries, pathogenesis and course of this disease are much more complex and variable. Therefore, specialists often have certain difficulties in diagnosis, management and treatment of these patients. To date, a large number of surgical interventions have been proposed for the treatment of moyamoya disease. Revascularization approaches include direct procedures (extra-intracranial microanastomoses), indirect methods (synangioses) and combined revascularization. The purpose of the review is to systematize current literature data on the pathogenesis, diagnosis, clinical patterns and surgical treatment of patients with moyamoya disease. results Outcomes of surgical revascularization and the role of its various components in combined approach are under particular attention.

[Russian media about medical innovations and technologies].

The current state of demand for medical information in the media has a high practical significance for the mass audience. Medicine is a science-intensive, rapidly developing field. In this regard, it is necessary to systematically inform the public about the achievements of medicine - in science, technology and industry, explaining the essence and possible consequences of a scientific discovery, popularizing methods of treatment of a particular disease, introducing society to innovative technological processes in the medical field, achievements and developments of the medical and pharmaceutical industry. The paper reviews the experience of media coverage of medical issues in the aspect of familiarity with innovations and technologies in the context of historical development both in our country and abroad. It also describes the presentation of medical topics in modern media - in periodicals, on radio, on television - in popular science programs or TV movies, in electronic sources. In addition, the article analyzes the genre diversity of the presentation of medical topics. The paper provides information about the media coverage of the main directions of the national project "Health" and its innovative directions.

[Issues of popularization of medical knowledge for health promotion and healthy lifestyle through mass media].

An important area of medical media is the preservation of health and a healthy lifestyle, the preservation and maintenance of adaptive properties of the body - the basis of content strategies of a large number of modern Russian media. To a greater or lesser extent and by virtue of their professional duties, it is the publications of doctors or interviews with them, as well as official research published in public and non-professional media, that popularize medical knowledge. The article focuses on the fact that the functions of popularizing health and a healthy lifestyle are inherent in the media, both special and for a wide range of the population. In addition to mass media that publish articles on preventive medicine and medicine of innovations and introduction of medical technologies, there are a number of mass media that cover medical knowledge for the population, in order to familiarize society with the achievements of medicine in the direction of maintaining health, maintaining a healthy lifestyle. This paper also concludes that all publications, all materials of Internet portals and messages, both in non-specialized and specialized media, most of the medical topics have a message of interpretation of the popularization of medical topics related to the preservation, maintenance of health and maintaining a healthy lifestyle. Popularization of medical knowledge in the media is an important direction for medical professionals and the public.

[Research of the structure of the mineral component of tooth enamel in connective tissue dysplasia by densitometry and atomic force microscopy in the early postpartum ontogenesis period]. / Issledovanie struktury mineral'nogo komponenta emali zubov pri displazii soedinitel'noi tkani metodami densitometrii i atomno-silovoi mikroskopii v rannem postnatal'nom periode ontogeneza.

OBJECTIVE: To give a quantitative and qualitative characteristic of the structure of the enamel's mineral component structure of impacted teeth with or without connective tissue dysplasia in different periods of early postnatal human ontogenesis using densitometry and atomic force microscopy. MATERIALS AND METHODS: The study involved 120 males with and without connective tissue dysplasia (CTD), which were divided into 3 equal subgroups (60 people with CTD and 60 people without CTD), 20 people in each, according to age: 15-20, 21-30, 31-40 years old. Each of the examined was removed either 3.8 or 4.8 tooth. To study the inorganic component of tooth enamel, a densitometric assessment of enamel's optical density was carried out using computed tomography in the Kodak Dental Systems software (Trophy 2000) and preparation of thin sections of tooth samples 3.8 or 4.8 for atomic force microscopy (AFM) according to the methods of Omsk State Medical University. RESULTS: The structure of tooth enamel in connective tissue dysplasia in the early postpartum period of ontogenesis is characterized by pronounced polymorphisms and an insufficient level of maturity. The ordering and orientation of the enamel prisms are disturbed due to insufficient packing density and a large distance between the enamel prisms at the age of 15-20, 21-30. The established changes indicate the incomplete nature of amelogenesis with connective tissue dysplasia at the indicated ages. CONCLUSIONS: In case of connective tissue dysplasia in the early postnatal period of ontogenesis, an incomplete amelogenesis is observed. This process is manifested by lower values of the mineral component's optical density, low packing of enamel prisms, a large distance between enamel prisms and their irregular shape.