Detalhe da pesquisa
1.
Synergistic Interactions of Indole-2-Carboxamides and ß-Lactam Antibiotics against Mycobacterium abscessus.
Antimicrob Agents Chemother
; 64(5)2020 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32041716
2.
The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes.
Int Microbiol
; 23(2): 161-170, 2020 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-31218537
3.
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
Brain
; 141(3): 673-687, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29415205
4.
Evaluation of Protein Kinase Inhibitors with PLK4 Cross-Over Potential in a Pre-Clinical Model of Cancer.
Int J Mol Sci
; 20(9)2019 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31035676
5.
Exploration of the labeling of [11C]tubastatin A at the hydroxamic acid site with [11C]carbon monoxide.
J Labelled Comp Radiopharm
; 59(1): 9-13, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26647018
6.
Design and Synthesis of (2-(5-Chloro-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)cyclopropyl)methanamine as a Selective Serotonin 2C Agonist.
Tetrahedron Lett
; 56(23): 3420-3422, 2015 Jun 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-26120215
7.
RI-1: a chemical inhibitor of RAD51 that disrupts homologous recombination in human cells.
Nucleic Acids Res
; 40(15): 7347-57, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22573178
8.
Differential Effects of HDAC6 Inhibition Versus Knockout During Hepatic Ischemia-reperfusion Injury Highlight Importance of HDAC6 C-terminal Zinc-finger Ubiquitin-binding Domain.
Transplantation
; 2024 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-38685198
9.
Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.
Biochemistry
; 52(51): 9155-66, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24295325
10.
Structural analogs of huperzine A improve survival in guinea pigs exposed to soman.
Bioorg Med Chem Lett
; 23(5): 1544-7, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23395652
11.
Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.
Antimicrob Agents Chemother
; 56(5): 2666-82, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22354304
12.
HDAC6 is a target for protection and regeneration following injury in the nervous system.
Proc Natl Acad Sci U S A
; 106(46): 19599-604, 2009 Nov 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-19884510
13.
On the path from chemistry to neuroscience: early explorations in chemical medicine under the mentorship of Dr. Erminio Costa, a neuroscientist with a big brain and a bigger heart.
Pharmacol Res
; 64(4): 327-9, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21708253
14.
The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice.
Proc Natl Acad Sci U S A
; 105(37): 14169-74, 2008 Sep 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-18784370
15.
Mercaptoacetamide: A promising zinc-binding group for the discovery of selective histone deacetylase 6 inhibitors.
Eur J Med Chem
; 209: 112887, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33035922
16.
Tetrahydroquinoline-Capped Histone Deacetylase 6 Inhibitor SW-101 Ameliorates Pathological Phenotypes in a Charcot-Marie-Tooth Type 2A Mouse Model.
J Med Chem
; 64(8): 4810-4840, 2021 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-33830764
17.
Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A.
J Am Chem Soc
; 132(31): 10842-6, 2010 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20614936
18.
The novel triple reuptake inhibitor JZAD-IV-22 exhibits an antidepressant pharmacological profile without locomotor stimulant or sensitization properties.
J Pharmacol Exp Ther
; 335(3): 762-70, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20864506
19.
A patent review of histone deacetylase 6 inhibitors in neurodegenerative diseases (2014-2019).
Expert Opin Ther Pat
; 30(2): 121-136, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31865813
20.
Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.
J Med Chem
; 63(9): 4579-4602, 2020 05 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32282200