Detalhe da pesquisa
1.
A restricted role for TYK2 catalytic activity in human cytokine responses revealed by novel TYK2-selective inhibitors.
J Immunol
; 191(5): 2205-16, 2013 Sep 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23894201
2.
Novel triazolo-pyrrolopyridines as inhibitors of Janus kinase 1.
Bioorg Med Chem Lett
; 23(12): 3592-8, 2013 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23642482
3.
Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Bioorg Med Chem Lett
; 22(24): 7627-33, 2012 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23107482
4.
Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
J Med Chem
; 56(11): 4764-85, 2013 Jun 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-23659214
5.
Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
J Med Chem
; 55(12): 5901-21, 2012 Jun 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-22591402
6.
Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
J Med Chem
; 55(13): 6176-93, 2012 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-22698084
7.
Aminoalkyl phenyl sulfones--a novel series of 5-HT7 receptor ligands.
Bioorg Med Chem Lett
; 16(5): 1255-8, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16337790
8.
Synthesis and structure-activity relationships of 8-azabicyclo[3.2.1]octane benzylamine NK1 antagonists.
Bioorg Med Chem Lett
; 16(4): 811-4, 2006 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16307878
9.
1-Phenyl-8-azabicyclo[3.2.1]octane ethers: a novel series of neurokinin (NK1) antagonists.
Bioorg Med Chem Lett
; 16(7): 2008-12, 2006 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16413782
10.
Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands.
Bioorg Med Chem Lett
; 14(3): 677-80, 2004 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-14741267
11.
Novel N1-(benzyl)cinnamamidine derived NR2B subtype-selective NMDA receptor antagonists.
Bioorg Med Chem Lett
; 13(4): 693-6, 2003 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12639560
12.
Orally efficacious NR2B-selective NMDA receptor antagonists.
Bioorg Med Chem Lett
; 13(4): 697-700, 2003 Feb 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-12639561