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1.
Mar Drugs ; 22(6)2024 Jun 07.
Artigo em Inglês | MEDLINE | ID: mdl-38921574

RESUMO

The addition of marine macroalgae to animal feed has garnered interest due to the demonstrated benefits of gut health in many livestock species. Most macroalgae have a higher mineral content than terrestrial vegetables, making them an attractive, sustainable source of minerals. However, some macroalgae contain elevated concentrations of iodine and arsenic, which may be transferred to the meat of livestock fed with macroalgae. This study evaluated the mineral profile of rabbit serum, muscle, liver, and kidney of rabbits fed diets supplemented with different marine macroalgae, with the goal of improving post-weaning gut health and reducing reliance on antibiotics. We found increased deposition of iodine in muscle, liver, and kidney due to macroalgae supplementation, which is particularly promising for regions with low iodine endemicity. Higher, though relatively low arsenic concentrations, compared to those in other animal meats and food sources, were also detected in the muscle, liver, and kidney of macroalgae-fed rabbits. The absence of apparent interactions with other micronutrients, particularly selenium, suggests that the inclusion of macroalgae in rabbit diets will not affect the overall mineral content. Enhanced bioavailability of elements such as phosphorus and iron may provide additional benefits, potentially reducing the need for mineral supplementation.


Assuntos
Ração Animal , Suplementos Nutricionais , Rim , Fígado , Alga Marinha , Animais , Coelhos , Alga Marinha/química , Rim/metabolismo , Rim/efeitos dos fármacos , Fígado/metabolismo , Ração Animal/análise , Músculos/metabolismo , Minerais , Iodo/administração & dosagem , Masculino , Arsênio/sangue , Dieta/veterinária
2.
Molecules ; 27(15)2022 Aug 03.
Artigo em Inglês | MEDLINE | ID: mdl-35956892

RESUMO

The objective of this study was to determine the trace element composition and the toxic metal residues in Galician cow's milk cheese produced in different systems (artisan, industrial, and organic). Fourteen elements (As, Cd, Co, Cr, Cu, Fe, Hg, I, Mn, Mo, Ni, Pb, Se, and Zn) were determined in 58 representative samples of Galician cheeses by inductively coupled plasma mass spectrometry. The toxic elements were present at low concentrations, similar to those reported for other unpolluted geographical areas. The essential elements were also within the normal range in cheeses. There were no statistically significant differences between smoked and unsmoked cheeses for any of the elements. Chemometric analyses (principal component analysis and cluster analysis) revealed that the industrial cheeses produced in Galicia using the milk from intensive dairy farms were different, in terms of elemental content, from artisan and organic cheeses, in which the elemental contents were similar.


Assuntos
Queijo , Oligoelementos , Animais , Bovinos , Queijo/análise , Fazendas , Feminino , Leite/química , Análise Espectral , Oligoelementos/análise
3.
Mar Drugs ; 19(4)2021 Apr 04.
Artigo em Inglês | MEDLINE | ID: mdl-33916596

RESUMO

The main objective was to determine the chemical, phytochemical, fatty acid and mineral profiles of three commercially relevant brown macroalgae (Laminaria digitata, Laminaria hyperborea and Ascophyllum nodosum) collected each season for two years off the west coast of Ireland. All the chemical, phytochemical, fatty acid and minerals analysed varied significantly depending on the macroalgal species, season and year of collection. Overall, the protein contents of macroalgae were negatively correlated with carbohydrate content. Protein (2-11%) was at its highest during winter and/or spring, decreasing to a minimum during summer and/or autumn. The three macroalgal species analysed in this study had clearly differentiated fatty acid profiles. The concentration of fatty acids was higher in A. nodosum compared with both Laminaria species. The mineral profile of the three macroalgal species was rich in essential metals, particularly Ca, Mg and P, while the levels of I were approximately 9- to 10-fold higher in both Laminaria spp. compared with A. nodosum. The levels of toxic metals (Cd, Hg and Pb) in all the macroalgal species studied were low in the current study; while the levels of total As were high (49-64 mg/kg DW macroalgae) compared with previous reports.


Assuntos
Ascophyllum/metabolismo , Laminaria/metabolismo , Valor Nutritivo , Compostos Fitoquímicos/análise , Estações do Ano , Antioxidantes/análise , Clima , Ácidos Graxos/análise , Minerais/análise , Especificidade da Espécie
4.
Reprod Domest Anim ; 55(1): 93-104, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31765032

RESUMO

Organic farm management combines best environmental practices, a high level of biodiversity, preservation of natural resources and high animal welfare standards. To meet these criteria, farmers must have livestock well adapted to local organic conditions and information about how different breeds and crosses perform under different conditions. The objective of this study was to compare the performance of different pure breeds and cross-breeds of cattle in organic dairy systems in Northern Spain. The data analysed were obtained from monthly records kept between 2010 and 2016 on organic farms registered in the regional milk recording system. Analysis of various traits indicated that the Holstein-Friesian breed suits the organic production system in the study region. Although the reproductive performance of Holstein-Friesian cows was poorer (in terms of number of services per conception) than that of cross-breed and Brown Swiss cows, the Holstein-Friesian produced more milk and lived longer. In addition, there was no difference in calving type or calving ease between the different breed groups. The better milk fat and protein yields produced by the crosses may be useful traits for farmers interested in milk transformation. The advantage of continuing to use Holstein-Friesian cattle is that the breed is predominant worldwide, and the genealogy is well documented. If Holstein-Friesian cattle continue to be used, the main priority will be to search for well-adapted bulls (particularly for pasture-based conditions) and to elaborate a genetic merit index for organic and pasture-based systems with the aim of predicting and minimizing genotype × environment interactions.


Assuntos
Cruzamento , Bovinos/classificação , Indústria de Laticínios , Animais , Bovinos/genética , Feminino , Fertilidade , Leite/estatística & dados numéricos , Agricultura Orgânica , Espanha
5.
Reprod Domest Anim ; 54(6): 902-911, 2019 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-31006148

RESUMO

Organic farming has traditionally given preference to indigenous breeds that are well adapted to local conditions; however, current trends towards increased yields may produce less robust animals with potentially low fertility. The Holstein-Friesian breed dominates dairy sector, although there is a general concern that these cows may not be well adapted to organic systems. This study aims to evaluate the reproductive performance of organic dairy herds in northern Spain, by comparing organically reared Holstein-Friesian with their counterparts reared on conventional farms and also with other organically reared breeds and crosses. Reproductive parameters were obtained for individual cows on organic, conventional pasture-based and conventional zero-grazing farms. The reproductive performance of Holstein-Friesian cows was slightly better in organic systems than in pasture-based conventional systems, but not than in zero-grazing conventional systems. The comparison of reproductive performance of Holstein-Friesian from organic and conventional systems and with other organically reared breeds and crosses enabled us to demonstrate that it is not the organic system that constrains the reproductive performance of Holstein-Friesian, but that the manifestation of oestrus is less marked than in other breeds. Breeding selection considering reproductive traits and appropriate management of oestrous detection would improve the reproductive performance of Holstein-Friesian cows.


Assuntos
Bovinos/fisiologia , Agricultura Orgânica/métodos , Reprodução/fisiologia , Animais , Cruzamento , Indústria de Laticínios/estatística & dados numéricos , Detecção do Estro , Feminino , Espanha
6.
J Dairy Res ; 86(1): 3-12, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30907720

RESUMO

Organic farming is believed by many to be an environmentally friendly production system that promotes the use of local forage while strongly limiting the input of chemicals, including allopathic treatments. As organic dairy farming has grown, farmers have realised that many available conventional breeds of cow are not well adapted to the new situations and that more 'robust' cows, able to function well in the constraining organic environment, are needed to yield acceptable longevity and productivity. In this review paper, the current breed diversity in organic dairy farming is analysed with the aim of identifying the types of cow that would best fulfil organic breeding goals. Unlike the conventional sector, organic dairy farming is very heterogeneous and no single type of cow can adapt well to all scenarios. There are advantages and disadvantages to the use of existing breeds (rustic Holstein-Friesian, other rustic breeds and crosses), and strong genotype × environment interactions demand different strategies for very diverse situations. Organic dairy farms producing milk for systems that recompense milk volume would benefit from using higher milk yielding cows, and rustic Holstein-Friesian cows may be the best option in such cases. Although most Holstein-Friesian cows are currently selected for use in conventional systems, this situation could be reversed by the implementation of an organic merit index that includes organic breeding goals. Farms producing milk either for systems that recompense milk solids or for transformation into dairy products would benefit from using breeds other than Holstein-Friesian or their crosses. Organic farmers who focus on rural tourism, farm schools or other businesses in which marketing strategies must be taken into account could benefit from using local breeds (when possible) or other rustic breeds that are highly valued by consumers.


Assuntos
Cruzamento , Bovinos/genética , Bovinos/fisiologia , Indústria de Laticínios/métodos , Agricultura Orgânica , Animais , Cruzamento/métodos , Feminino , Interação Gene-Ambiente , Variação Genética/genética , Variação Genética/fisiologia , Genótipo , Lactação/genética , Lactação/fisiologia , Longevidade , Leite/química , Agricultura Orgânica/métodos , Seleção Genética
7.
J Dairy Res ; 83(4): 464-467, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27845018

RESUMO

This research communication aimed to compare somatic cell count (SCC), the main marker of udder health status, in organic farms not using antibiotics (O, n = 6), organic farms using antibiotics (OA, n = 7) and conventional farms (CA, n = 5) using antibiotic treatments, all of them at pasture. SCC was statistically significantly higher in O (173780) compared to CA (93325) and OA (107152). Milk yield had a significant diluting effect on SCC and differences between groups increased with parities. Stratified analysis of SCC depending on lactation number and % of monthly SCC test with different linear scores (LS) indicated that there is no difference in udder health in the primiparous heifers from the three groups of farms, but it deteriorates in older cows because of chronic infections in O (possibly due to lack of antibiotic use). Our results suggest that the non-use of antibiotics had an effect in udder health leading to higher occurrence of clinical and subclinical mastitis. Therefore, preventive management practices for mastitis control are essential in organic farms.


Assuntos
Antibacterianos/administração & dosagem , Indústria de Laticínios/métodos , Glândulas Mamárias Animais/fisiopatologia , Mastite Bovina/prevenção & controle , Agricultura Orgânica , Animais , Bovinos , Contagem de Células , Feminino , Nível de Saúde , Mastite Bovina/epidemiologia , Mastite Bovina/fisiopatologia , Leite/citologia
8.
Homeopathy ; 105(1): 102-8, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26828005

RESUMO

Organic farming principles promote the use of unconventional therapies as an alternative to chemical substances (which are limited by organic regulations), with homeopathy being the most extensive. Traditionally, Spain has had little faith in homeopathy but its use in organic farming is growing. Fifty-six Spanish organic dairy farmers were interviewed to obtain what we believe to be the first data on the use of homeopathy in organic dairy cattle in Spain. Only 32% of farms use some sort of alternative therapy (16.1% homeopathy, 10.7% phytotherapy and 5.3% using both therapies) and interestingly, a clear geographical pattern showing a higher use towards the East (similar to that in the human population) was observed. The main motivation to use homeopathy was the need to reduce chemical substances promoted by organic regulations, and the treatment of clinical mastitis being the principle reason. The number of total treatments was lower in farms using homeopathy compared with those applying allopathic therapies (0.13 and 0.54 treatments/cow/year respectively) and although the bulk SCC was significantly higher (p < 0.001) in these farms (161,826 and 111,218 cel/ml, respectively) it did not have any negative economical penalty for the farmer and milk quality was not affected complying with the required standards; on the contrary homeopathic therapies seems to be an alternative for reducing antibiotic treatments, allowing farmers to meet the organic farming principles.


Assuntos
Laticínios , Homeopatia/métodos , Mastite Bovina/prevenção & controle , Agricultura Orgânica/métodos , Animais , Bovinos , Feminino , Fitoterapia/métodos , Espanha
9.
Res Vet Sci ; 171: 105203, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38432158

RESUMO

Although haemolysis is the most common source of preanalytical error in clinical laboratories, its influence on cattle biochemistry remains poorly understood. The effect of haemolysis and its clinical relevance were investigated in 70 samples in which haemolysis was artificially induced (by spiking with increasing amounts of haemolysate, yielding 0.0%, 0.2%, 0.5%, 1.0%, 2.5%, 5.0% and 10% haemolysis degree (HD)), focusing on key parameters for bovine metabolic health assessment, including albumin, alkaline phosphatase (ALP), aspartate aminotransferase (AST), blood urea nitrogen (BUN), calcium (Ca), cholesterol, creatinine, creatine kinase (CK), gamma-glutamyl transferase (GGT), globulins, magnesium (Mg), phosphorus (P), total bilirubin (TBIL) and total proteins (TP). Preanalytical haemolysis significantly affected most (8 of 14) of the biochemical parameters analysed, leading to significant increases in concentrations of albumin (starting at 5% HD), cholesterol (at 5% HD) and P (at 10% HD) and to significant decreases in Ca (at 2.5% HD), creatinine (at 5% HD), globulins (at 10% HD), TBIL (at 2.5% HD) and TP (at 10% HD). Comparison of the present and previous data indicated that, for each parameter, the HD required to produce significant bias and the clinical relevance of over- and underestimation are variable and appear to depend on the analytical technique used. Therefore, different laboratories should evaluate the influence of haemolysis in their analytical results and provide advice to clinicians accordingly. Affected parameters should be interpreted together with clinical signs and other analytical data to minimize misinterpretations (false or masked variations). Finally, due to the significant impact on numerous parameters and the limited potential for correction, we recommend rejection of samples with >10% HD.


Assuntos
Doenças dos Bovinos , Globulinas , Bovinos , Animais , Hemólise , Creatinina , Colesterol , Cálcio , Albuminas
10.
Meat Sci ; 216: 109584, 2024 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-38970931

RESUMO

The addition of macroalgae to livestock diets has demonstrated to enhance the quality of meat by improving the muscle stability, antioxidant capacity and fatty acid profile. However, information regarding rabbit meat is scarce. This study evaluated the effect of adding 1.025% of different macroalgae, dehydrated and as extracts (Saccharina latissima, Himanthalia elongata and Ulva spp.) to the diet of growing rabbits. Dietary supplementation with the Ulva spp. extract increased the fat content (0.96% vs 0.33% in control group) and the proportion of monounsaturated fatty acids (by 22%; P ≤ 0.022), but did not affect the moisture, protein or ash contents or the physicochemical properties of the rabbit longissiumus lumborum muscle. The antioxidant status of the meat was adequate and was not affected by the dietary supplements. The sensorial properties of the meat were also not affected, and dietary supplementation with both S. latissima and H. elongata actually enhanced the flavour and juiciness of the meat (P ≤ 0.01). Altogether, the study findings indicate that the addition of these sustainable ingredients to rabbit feed did not negatively affect meat quality, and some of them may potentially improve specific characteristics, which could make this meat more attractive to consumers.


Assuntos
Ração Animal , Dieta , Suplementos Nutricionais , Músculo Esquelético , Alga Marinha , Animais , Coelhos , Ração Animal/análise , Alga Marinha/química , Dieta/veterinária , Músculo Esquelético/química , Antioxidantes/análise , Ulva/química , Masculino , Paladar , Carne/análise , Ácidos Graxos/análise
11.
Res Vet Sci ; 174: 105309, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38781816

RESUMO

A balanced trace element status is essential for the optimal functioning of all organisms. However, their concentrations are often altered in diverse medical conditions. This study investigated the trace element profiles in plasma samples of dogs with endocrine diseases and used chemometric techniques to explore their associations with biochemical data. Thirteen elements (As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Mo, Ni, Pb, Se and Zn) were measured in 40 dogs with hyperadrenocorticism (HAC), 29 dogs with diabetes mellitus (DM), 11 dogs with hypothyroidism (HT) and 30 control dogs using inductively coupled plasma mass spectrometry (ICP-MS). Statistically significant differences were observed for As, Cu, Mo, Se and Zn. In comparison with the control group, the HT patients had higher As and lower Se levels, while the HAC group had higher concentrations of Mo. All three disease groups had higher Cu and Zn concentrations than the control group, with the DM group having higher Cu concentrations and the HAC group higher Zn concentrations than the other endocrinopathy groups. The chemometric analysis revealed distinctive association patterns for discriminating each pathology group and the control group. Moreover, the analysis revealed the following associations: Mo with glucose levels and Cu with fructosamine levels in the DM group, As with cortisol levels in the HAC group, and Se with TT4 levels and As with TSH levels in the HT group. The study findings provide valuable insights into the complex relationships between trace elements and endocrinopathies, elucidating the associations with biochemical markers in these diseases. Larger-scale studies are necessary to fully understand the observed relationships and explore the potential clinical applications.


Assuntos
Doenças do Cão , Doenças do Sistema Endócrino , Oligoelementos , Doenças do Cão/sangue , Doenças do Sistema Endócrino/sangue , Doenças do Sistema Endócrino/veterinária , Oligoelementos/análise , Oligoelementos/sangue , Fatores de Risco , Masculino , Feminino , Animais , Cães , Espectrofotometria Atômica/veterinária
12.
Chemosphere ; 351: 141146, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-38211792

RESUMO

Recent ecotoxicological studies have indicated mercury (Hg) contamination in aquatic ecosystems in the Amazon Basin. Although Hg contamination can be associated with small-scale gold mining, the soils of the Amazon region have naturally high Hg concentrations, and can be transported to aquatic ecosystems via deforestation and mining activities. Biomagnification of Hg can pose risks to the local human population; therefore, its concentration in fish tissues must be monitored consistently. Fast and sensitive Hg determination is required for continuously monitoring ecosystems impacted by mineral exploration. The direct mercury analyzer (DMA-80) is widely used for determining total Hg levels in tissue samples; it is fast and cost-effective, without requiring sample preparation. Here, we determined the sensitivity and specificity of Hg detection accomplished using DMA-80, and whether these results are reliable compared to those obtained using Inductively Coupled Plasma Mass Spectrometer (ICP-MS), which is the gold standard. We obtained 106 paired dried samples of muscle tissue from fish species occupying different trophic levels in the Lower Amazon region, and analyzed them using both equipment (DMA-80 and ICP-MS). The results obtained using DMA-80 had an overall Hg mean of 1.90 ± 0.18 mg/kg which was higher (p < 0.05) than the mean of those obtained using ICP-MS (1.55 ± 0.13 mg/kg). Linear regression analysis comparing the Hg levels obtained using both devices was within the 95% prediction interval, and a high coefficient of correlation showed agreement between the devices (r = 0.979; 0.069 to 0.986, 95% CI). Bland-Altman analysis showed that DMA-80 had a positive bias of 6.5% in relation to ICP-MS, which is more evident in samples with high Hg concentrations. DMA-80 was efficient in determining whether the Hg levels exceeded the maximum allowed levels required by the European Union, USA, and Brazil, showing a specificity and sensitivity of above 95%.


Assuntos
Mercúrio , Animais , Humanos , Mercúrio/análise , Ecossistema , Sensibilidade e Especificidade , Peixes , Espectrometria de Massas , Monitoramento Ambiental
13.
EFSA J ; 22(7): e8858, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-38993589

RESUMO

EFSA performs dietary exposure assessments for food-producing and non-food-producing animals to deliver risk assessment for mandates on the presence of contaminants in feed. The CONTAM and FEEDAP Panels identified the need to update the animal dietary exposure assessment model used in those assessments in CONTAM Scientific Opinions since 2011 in cases where insufficient occurrence data are available on species specific compound feeds. The Panels proposed in this statement a series of model diets based on groups of feed materials with the possibility to use different feed materials in their formulation. The Panels considered that the currently proposed model diets cover the need of the CONTAM Panel to assess the dietary exposure of animals to contaminants in feed.

14.
EFSA J ; 22(7): e8906, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-39086459

RESUMO

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of an essential oil obtained from the fruit of Carum carvi L. (caraway oil), when used as a sensory additive in feed and water for drinking for all animal species. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel concluded that the use of caraway oil is of no concern up to the following concentrations in complete feed: 9 mg/kg for chickens for fattening, 13 mg/kg for laying hens, 12 mg/kg for turkeys for fattening, 16 mg/kg for piglets, 19 mg/kg for pigs for fattening, 24 mg/kg for sows, 35 mg/kg for veal calves (milk replacer), 11 mg/kg for cattle for fattening, 10 mg/kg for dairy cows, sheep, goats, horses and rabbits, 25 mg/kg for salmonids and dogs. These conclusions were extrapolated to other physiologically related species. For cats, ornamental fish and other species, no conclusion can be drawn. The use of caraway oil in animal feed under the proposed conditions of use is safe for the consumer and the environment. The additive under assessment should be considered as an irritant to skin and eyes, and as a respiratory and skin sensitiser. When handling the essential oil, exposure of unprotected users to perillaldehyde may occur. Therefore, to reduce the risk, the exposure of the users should be minimised. Since C. carvi and its preparations were recognised to flavour food and its function in feed would be essentially the same as that in food, no further demonstration of efficacy was considered necessary.

15.
EFSA J ; 22(7): e8950, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-39086458

RESUMO

Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of liquid l-lysine base produced with a genetically modified strain of Corynebacterium glutamicum as a nutritional feed additive for all animal species. The l-lysine base liquid produced with C. glutamicum NRRL B-67535 and NRRL B-67439 is currently authorised as a nutritional additive for all animal species. The present application is aimed at modifying the current authorisation to include C. glutamicum NRRL B-68248 as a production strain. The new production strain qualifies for the qualified presumption of safety approach when used for production purposes. It was unambiguously identified as C. glutamicum and was shown not to harbour acquired antimicrobial resistance determinants for antibiotics of human and veterinary importance. All the introduced sequences or mutations were considered to be safe, and no viable cells or DNA of the NRRL B-68248 strain was detected in the final product. Therefore, the final product does not pose any safety concern associated with the production strain. l-Lysine base produced using C. glutamicum NRRL B-68248 does not represent a risk for the target species, the consumer or the environment. The additive was considered to be neither irritant to skin or the eyes, nor a dermal sensitiser. l-Lysine base produced with C. glutamicum NRRL B-68248 is considered to be an efficacious source of the essential amino acid l-lysine for non-ruminant animal species. For the supplemental l-lysine to be as efficacious in ruminants as in non-ruminant species, it would require protection against degradation in the rumen.

16.
EFSA J ; 22(8): e8951, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-39119057

RESUMO

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the feed additive consisting of endo-1,4-beta-xylanase (produced with Trichoderma reesei MUCL 49755) and endo-1,3(4)-beta-glucanase (produced with T. reesei MUCL 49754) (AveMix® XG 10/AveMix® XG 10 L) for the renewal of its authorisation as zootechnical feed additive for pigs for fattening, minor porcine species for fattening and turkeys for fattening. The applicant declared a change in the carrier material used in AveMix® XG 10 from soybean meal to calcium carbonate + wheat flour or calcium carbonate + sepiolite. The applicant provided evidence that the additive Avemix® XG 10 with calcium carbonate + wheat flour and Avemix® XG 10 L comply with the conditions of the authorisation. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) noted that no data were submitted to support compliance of the formulation of Avemix® XG 10 with calcium carbonate + sepiolite with the conditions of the authorisation. The FEEDAP Panel concluded that both forms of the additive remain safe for pigs for fattening, minor porcine species for fattening and turkeys for fattening, consumers and the environment. Regarding the safety for the user, Avemix® XG 10 formulated with calcium carbonate + sepiolite and Avemix® XG 10 L are not irritant to skin and eyes. No conclusions on the irritation potential of Avemix® XG 10 formulated with calcium carbonate + wheat flour could be drawn. The additive in all its formulations is considered a respiratory and skin sensitiser. There was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation.

17.
EFSA J ; 22(7): e8852, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-39010866

RESUMO

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of endo-1,4-beta-xylanase (produced with Trichoderma reesei MUCL 49755) and endo-1,3(4)-beta-glucanase (produced with T. reesei MUCL 49754) (AveMix® XG 10/AveMix® XG 10 L) as a zootechnical feed additive for weaned and suckling piglets. The additive is already authorised for use in weaned piglets. This scientific opinion concerns the request for the renewal of the authorisation of the additive for weaned piglets and the extension of use to suckling piglets. The applicant declared a change in the carrier material used in AveMix® XG 10 from soybean meal to calcium carbonate + wheat flour or calcium carbonate + sepiolite. The applicant provided evidence that the additive AveMix® XG 10 with calcium carbonate + wheat flour and AveMix® XG 10 L comply with the conditions of the authorisation. The EFSA Panel on Additives and Products or Substances used in Animal FEED (FEEDAP) noted that no data were submitted to support compliance of the formulation of AveMix® XG 10 with calcium carbonate + sepiolite with the conditions of the authorisation. The FEEDAP Panel concluded that both formulations of the additive (powder and liquid) remain safe for the target species, consumers and the environment, and that the extension of use to suckling piglets would not affect these conclusions. AveMix® XG 10 formulated with calcium carbonate + sepiolite and AveMix® XG 10 L are not irritant to skin and eyes. No conclusions on the irritation potential of AveMix® XG 10 formulated with calcium carbonate + wheat flour could be drawn. The additive in all its formulations is considered a respiratory and skin sensitiser. There was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation for weaned piglets. The Panel concluded that the additive is efficacious in suckling piglets at 4000 XU and 900 BGU/kg complete feed.

18.
EFSA J ; 22(7): e8854, 2024 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-39010864

RESUMO

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of the feed additive consisting of endo-1,4-beta-xylanase (produced with Trichoderma reesei MUCL 49755), endo-1,3(4)-beta-glucanase (produced with T. reesei MUCL 49754) and polygalacturonase (produced with Aspergillus fijiensis CBS 589.94) (AveMix® 02 CS/ AveMix® 02 CS L) as a zootechnical feed additive for weaned and suckling piglets. The additive is already authorised for use with weaned piglets. This scientific opinion concerns the request for the renewal of the authorisation of the additive for weaned piglets and the extension of use to suckling piglets. The applicant provided evidence that the additive currently in the market complies with the conditions of the authorisation. There was no new evidence that would lead the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) to reconsider its previous conclusions that the additive is safe for weaned piglets, the consumer and the environment under the authorised conditions of use. This conclusion applied also to the new target species (suckling piglets) for which a request for an extension of use was made. The additive in both formulations (powder and liquid) is not irritant to skin or eyes but should be considered a dermal and respiratory sensitiser. There was no need for assessing the efficacy of the additive in the context of the renewal of the authorisation for weaned piglets. The Panel concluded that the additive is efficacious in suckling piglets at 2140 XU, 1230 BGU and 46 PGLU/kg complete feed.

19.
EFSA J ; 22(5): e8801, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38764477

RESUMO

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of a tincture from the leaves of Eucalyptus globulus Labill. (eucalyptus tincture) when used as a sensory additive for all animal species. The product is a ■■■■■ solution, with a dry matter content of ~ 1.86%, which contains on average 0.454% phenolic acids and flavonoids (of which 0.280% was gallic acid), 0.0030% 1,8-cineole and 0.00012% methyleugenol. In the absence of analytical data on the occurrence of mono- or diformylated adducts of acylphloroglucinols with terpenes in the tincture and in the absence of toxicity data, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) could not conclude on the use of eucalyptus tincture for long-living and reproductive animals. For short-living animals (species for fattening), the additive was considered of no concern at 4 mg/kg complete feed for chickens for fattening, 5 mg/kg for turkeys for fattening, 6 mg/kg for piglets and rabbits for meat production, 7 mg/kg for pigs for fattening, 16 mg/kg for veal calves (milk replacer), 14 mg/kg for cattle for fattening, sheep/goats and horses for fattening, and 15 mg/kg for salmonids. These levels were extrapolated to physiologically related minor species. No safety concern would arise for the consumer from the use of eucalyptus tincture up to the levels in feed considered of no concern. Eucalyptus tincture should be considered as irritant to skin and eyes, and as a dermal and respiratory sensitiser. The use of eucalyptus tincture as a flavour in animal feed was not expected to pose a risk for the environment. Since the leaves of E. globulus and their preparations were recognised to flavour food and their function in feed would be essentially the same, no demonstration of efficacy was considered necessary.

20.
EFSA J ; 22(5): e8798, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38764478

RESUMO

Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of tinctures obtained from the dried leaves of Ginkgo biloba L. (ginkgo tinctures) when used as sensory additives. The tinctures are water/ethanol solutions with a dry matter content of 5.7% (tincture A) and 3.0% (tincture B). The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) concluded that the additives under assessment are safe for the target species at the following concentrations in complete feed: (i) ginkgo tincture A at 240 mg/kg for horses and 750 mg/kg for dogs; (ii) ginkgo tincture B at 600 mg/kg for horses and 50 mg/kg for all other animal species. No safety concern would arise for the consumer from the use of ginkgo tinctures up to the maximum proposed use level in feed for the target species. The tinctures should be considered as irritants to skin and eyes, and as dermal and respiratory sensitisers. The use of ginkgo tinctures at the proposed use levels in feed for the target species is not considered to be a risk to the environment. While the available data indicate that Ginkgo preparations have a distinctive flavour profile, there is no evidence that ginkgo tinctures would impart flavour to a food or feed matrix. Therefore, the FEEDAP Panel cannot conclude on the efficacy of the additives.

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