Detalhe da pesquisa
1.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-25459880
2.
Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.
ACS Med Chem Lett
; 12(9): 1396-1404, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531948
3.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551024
4.
Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction.
J Med Chem
; 62(9): 4683-4702, 2019 05 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30973731
5.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ACS Med Chem Lett
; 10(11): 1518-1523, 2019 Nov 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-31749904
6.
Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer Res
; 66(23): 11100-5, 2006 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-17145850
7.
Approaches to target tractability assessment - a practical perspective.
Medchemcomm
; 9(4): 606-613, 2018 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108951
8.
3,5-Disubstituted-indole-7-carboxamides as IKKß Inhibitors: Optimization of Oral Activity via the C3 Substituent.
ACS Med Chem Lett
; 9(12): 1164-1169, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613320
9.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30344914
10.
Evaluation of the tubulin-bound paclitaxel conformation: synthesis, biology, and SAR studies of C-4 to C-3' bridged paclitaxel analogues.
J Med Chem
; 50(4): 713-25, 2007 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-17263521
11.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26854747
12.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27109867
13.
An efficient and highly diastereoselective synthesis of GSK1265744, a potent HIV integrase inhibitor.
Org Lett
; 17(3): 564-7, 2015 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-25615910
14.
Druggability Assessment of Allosteric Proteins by Dynamics Simulations in the Presence of Probe Molecules.
J Chem Theory Comput
; 8(7): 2435-2447, 2012 Jul 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-22798729
15.
Conformational evolution: the wiggling of peptides into amyloid.
Structure
; 11(3): 242, 2003 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-12623011
16.
On the stability of a single-turn alpha-helix: the single versus multiconformation problem.
J Am Chem Soc
; 125(3): 632-3, 2003 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-12526653
17.
Structural features of paramyxovirus F protein required for fusion initiation.
Biochemistry
; 42(22): 6645-55, 2003 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-12779319
18.
Dynamics and fluidity of amyloid fibrils: a model of fibrous protein aggregates.
J Am Chem Soc
; 124(51): 15150-1, 2002 Dec 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-12487571
19.
The bioactive Taxol conformation on beta-tubulin: experimental evidence from highly active constrained analogs.
Proc Natl Acad Sci U S A
; 101(27): 10006-11, 2004 Jul 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-15226503
20.
A target site for template-based design of measles virus entry inhibitors.
Proc Natl Acad Sci U S A
; 101(15): 5628-33, 2004 Apr 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-15056763