Detalhe da pesquisa
1.
CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy.
Nature
; 569(7755): 270-274, 2019 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31043744
2.
Leveraging intrinsic flexibility to engineer enhanced enzyme catalytic activity.
Proc Natl Acad Sci U S A
; 119(23): e2118979119, 2022 06 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35658075
3.
Hypersensitivity to ferroptosis in chromophobe RCC is mediated by a glutathione metabolic dependency and cystine import via solute carrier family 7 member 11.
Proc Natl Acad Sci U S A
; 119(28): e2122840119, 2022 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35867762
4.
Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc Natl Acad Sci U S A
; 117(23): 13000-13011, 2020 06 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32434918
5.
Enzyme-mediated depletion of methylthioadenosine restores T cell function in MTAP-deficient tumors and reverses immunotherapy resistance.
Cancer Cell
; 41(10): 1774-1787.e9, 2023 10 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-37774699
6.
Cyst(e)inase-Rapamycin Combination Induces Ferroptosis in Both In Vitro and In Vivo Models of Hereditary Leiomyomatosis and Renal Cell Cancer.
Mol Cancer Ther
; 21(3): 419-426, 2022 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35086957
7.
Bypassing evolutionary dead ends and switching the rate-limiting step of a human immunotherapeutic enzyme.
Nat Catal
; 5(10): 952-967, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36465553
8.
Cysteine depletion induces pancreatic tumor ferroptosis in mice.
Science
; 368(6486): 85-89, 2020 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32241947
9.
Reversal of indoleamine 2,3-dioxygenase-mediated cancer immune suppression by systemic kynurenine depletion with a therapeutic enzyme.
Nat Biotechnol
; 36(8): 758-764, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-30010674
10.
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth.
Nat Med
; 23(1): 120-127, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27869804
11.
Discovery of a substrate selectivity motif in amino acid decarboxylases unveils a taurine biosynthesis pathway in prokaryotes.
ACS Chem Biol
; 8(10): 2264-71, 2013 Oct 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-23972067
12.
SCHEMA-designed variants of human Arginase I and II reveal sequence elements important to stability and catalysis.
ACS Synth Biol
; 1(6): 221-8, 2012 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22737599