Detalhe da pesquisa
1.
Design and synthesis of bridged piperidine and piperazine isosteres.
Bioorg Med Chem Lett
; 28(15): 2627-2630, 2018 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29937060
2.
Synthesis of a 6-Aza-Isoindolinone-Based Inhibitor of Phosphoinositide 3-Kinase γ via Ruthenium-Catalyzed [2 + 2 + 2] Cyclotrimerization.
ACS Med Chem Lett
; 10(1): 117-120, 2019 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-30655957
3.
Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase γ (PI3Kγ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
J Med Chem
; 61(12): 5245-5256, 2018 06 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-29847724
4.
Discovery of Highly Isoform Selective Thiazolopiperidine Inhibitors of Phosphoinositide 3-Kinase γ.
J Med Chem
; 58(14): 5684-8, 2015 Jul 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-26121481
5.
Discovery and Characterization of a Water-Soluble Prodrug of a Dual Inhibitor of Bacterial DNA Gyrase and Topoisomerase IV.
ACS Med Chem Lett
; 6(7): 822-6, 2015 Jul 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-26191374
6.
Second-generation antibacterial benzimidazole ureas: discovery of a preclinical candidate with reduced metabolic liability.
J Med Chem
; 57(21): 8792-816, 2014 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25317480