Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

Cardiovascular dysfunction is highly comorbid with mood disorders, such as anxiety and depression. However, the mechanisms linking cardiovascular dysfunction with the core behavioral features of mood disorder remain poorly understood. In this study, we used mice bearing a knock-in sarcomeric mutation, which is exhibited in human hypertrophic cardiomyopathy (HCM), to investigate the influence of HCM over the development of anxiety and depression. We employed behavioral, MRI, and biochemical techniques in young (3-4 mo) and aged adult (7-8 mo) female mice to examine the effects of HCM on the development of anxiety- and depression-like behaviors. We focused on females because in both humans and rodents, they experience a 2-fold increase in mood disorder prevalence vs. males. Our results showed that young and aged HCM mice displayed echocardiographic characteristics of the heart disease condition, yet only aged HCM females displayed anxiety- and depression-like behaviors. Electrocardiographic parameters of sympathetic nervous system activation were increased in aged HCM females vs. controls and correlated with mood disorder-related symptoms. In addition, when compared with controls, aged HCM females exhibited adrenal gland hypertrophy, reduced volume in mood-related brain regions, and reduced hippocampal signaling proteins, such as brain-derived neurotrophic factor and its downstream targets vs. controls. In conclusion, prolonged systemic HCM stress can lead to development of mood disorders, possibly through inducing structural and functional brain changes, and thus, mood disorders in patients with heart disease should not be considered solely a psychologic or situational condition.-Dossat, A. M., Sanchez-Gonzalez, M. A., Koutnik, A. P., Leitner, S., Ruiz, E. L., Griffin, B., Rosenberg, J. T., Grant, S. C., Fincham, F. D., Pinto, J. R. Kabbaj, M. Pathogenesis of depression- and anxiety-like behavior in an animal model of hypertrophic cardiomyopathy.

Climate change and health informatics: pilot survey of perspectives across the field.

OBJECTIVE: Establish a baseline of informatics professionals' perspectives on climate change and health. MATERIALS AND METHODS: Anonymized survey sent to 9 informatics listservs March 31, 2022 to April 15, 2022. RESULTS: N = 85 participants completed part or all of survey. Majority of participants worked at hospitals with 1000+ employees (73%) in urban areas (60%) in the United States. Respondents broadly reported general understanding of climate change and health (51%), but 71% reported unfamiliarity with technologies that could help clinicians and informaticians address the impacts of climate change. Seventy-one percent of surveyed wanted climate-driven environmental health information included in EHRs. Seventy-six percent of respondents reported that informaticians should be involved in institutional decarbonization. Seventy-eight percent of respondents felt that it was extremely, very, or moderately important to receive education on climate change. DISCUSSION: General consensus on need to engage informaticians in climate change response, but gaps identified in knowledge dissemination and tools for adaptation and mitigation. CONCLUSION: Informaticians broadly concerned about climate change and want to be engaged in efforts to combat it, but further education and tool development needed.

Depression, anxiety, and burnout among hospital workers during the COVID-19 pandemic: A cross-sectional study.

OBJECTIVES: Healthcare personnel have faced unprecedented mental health challenges during the COVID-19 pandemic. The study objective is to assess differences in depression, anxiety, and burnout among healthcare personnel with various occupational roles and whether financial and job strain were associated with these mental health outcomes. METHODS: We employed an anonymous survey between July and August 2020 at an urban county hospital in California, USA. We assessed depression, anxiety, and burnout using validated scales, and asked questions on financial strain and job strain. We performed logistic and linear regression analyses. RESULTS: Nurses (aOR 1.93, 95% CIs 1.12, 3.46), social workers (aOR 2.61, 95% CIs 1.35, 5.17), service workers (aOR 2.55, 95% CIs 1.20, 5.48), and administrative workers (aOR 2.93, 95% CIs 1.57, 5.61) were more likely than physicians to screen positive for depression. The odds of screening positive for anxiety were significantly lower for ancillary workers (aOR 0.32, 95% CIs 0.13-0.72) compared with physicians. Ancillary (aB = -1.77, 95% CIs -1.88, -0.47) and laboratory and pharmacy workers (aB -0.70, 95% CI -1.34, -0.06) reported lower levels of burnout compared with physicians. Financial strain partially accounted for differences in mental health outcomes across job categories. Lack of time to complete tasks and lack of supervisory support were associated with higher odds of screening positive for depression. Less job autonomy was associated with higher odds of screening positive for anxiety and higher burnout levels. CONCLUSIONS: We found significant disparities in mental health outcomes across occupational roles. Policies to mitigate the adverse impact of COVID-19 on health workers' mental health should include non-clinical staff and address financial support and job characteristics for all occupational roles.

Medical Student Spirituality and Substance Use.

OBJECTIVES: Although medical students report relatively high levels of substance use, little is known about the risk and protective factors associated with substance use in this population. This study sought to examine the link between spirituality and substance use among medical students. METHODS: As part of a larger study, medical students from all 9 medical schools in the state of Florida were invited to complete an anonymous survey pertaining to distress and well-being. Responses to items assessing self-reported spirituality and substance use were examined and descriptive statistics were analyzed. RESULTS: Data from 868 medical students (57% female) were included. Of these, 22.6% described themselves as "non-spiritual," 31.0% described themselves as "spiritual," 18.5% engaged in informal spiritual practices, and 27.9% reported formal spiritual/religious practices. Students who reported stronger spirituality also reported lower rates of substance use. Though 31% of respondents across all levels of spirituality reported that their alcohol consumption increased since starting medical school, rates of binge drinking after exams were inversely related to level of spirituality. CONCLUSIONS: Self-reported spirituality appears to be associated with decreased risk of substance use in medical school. Future studies should examine this relation in greater depth.