Pesquisa | Biblioteca Virtual em Saúde Fiocruz

1.

Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis.

Pan, Rongqing; Ryan, Jeremy; Pan, Deng; Wucherpfennig, Kai W; Letai, Anthony.

Cell ; 185(9): 1521-1538.e18, 2022 04 28.

Artigo em Inglês | MEDLINE | ID: mdl-35447071

2.

Death in the Fas, ELANE.

Letai, Anthony.

Cell ; 184(12): 3081-3083, 2021 06 10.

Artigo em Inglês | MEDLINE | ID: mdl-34115969

3.

Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins.

Singh, Rumani; Letai, Anthony; Sarosiek, Kristopher.

Nat Rev Mol Cell Biol ; 20(3): 175-193, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30655609

4.

Drug-induced death signaling strategy rapidly predicts cancer response to chemotherapy.

Montero, Joan; Sarosiek, Kristopher A; DeAngelo, Joseph D; Maertens, Ophélia; Ryan, Jeremy; Ercan, Dalia; Piao, Huiying; Horowitz, Neil S; Berkowitz, Ross S; Matulonis, Ursula; Jänne, Pasi A; Amrein, Philip C; Cichowski, Karen; Drapkin, Ronny; Letai, Anthony.

Cell ; 160(5): 977-989, 2015 Feb 26.

Artigo em Inglês | MEDLINE | ID: mdl-25723171

5.

Relative mitochondrial priming of myeloblasts and normal HSCs determines chemotherapeutic success in AML.

Vo, Thanh-Trang; Ryan, Jeremy; Carrasco, Ruben; Neuberg, Donna; Rossi, Derrick J; Stone, Richard M; Deangelo, Daniel J; Frattini, Mark G; Letai, Anthony.

Cell ; 151(2): 344-55, 2012 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-23063124

6.

Mitochondria-Judges and Executioners of Cell Death Sentences.

Bhola, Patrick D; Letai, Anthony.

Mol Cell ; 61(5): 695-704, 2016 Mar 03.

Artigo em Inglês | MEDLINE | ID: mdl-26942674

7.

Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration.

Sánchez-Rivera, Francisco J; Ryan, Jeremy; Soto-Feliciano, Yadira M; Clare Beytagh, Mary; Xuan, Lucius; Feldser, David M; Hemann, Michael T; Zamudio, Jesse; Dimitrova, Nadya; Letai, Anthony; Jacks, Tyler.

Proc Natl Acad Sci U S A ; 118(23)2021 06 08.

Artigo em Inglês | MEDLINE | ID: mdl-34074758

8.

Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.

DiNardo, Courtney D; Jonas, Brian A; Pullarkat, Vinod; Thirman, Michael J; Garcia, Jacqueline S; Wei, Andrew H; Konopleva, Marina; Döhner, Hartmut; Letai, Anthony; Fenaux, Pierre; Koller, Elizabeth; Havelange, Violaine; Leber, Brian; Esteve, Jordi; Wang, Jianxiang; Pejsa, Vlatko; Hájek, Roman; Porkka, Kimmo; Illés, Árpád; Lavie, David; Lemoli, Roberto M; Yamamoto, Kazuhito; Yoon, Sung-Soo; Jang, Jun-Ho; Yeh, Su-Peng; Turgut, Mehmet; Hong, Wan-Jen; Zhou, Ying; Potluri, Jalaja; Pratz, Keith W.

N Engl J Med ; 383(7): 617-629, 2020 08 13.

Artigo em Inglês | MEDLINE | ID: mdl-32786187

9.

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages.

Guerriero, Jennifer L; Sotayo, Alaba; Ponichtera, Holly E; Castrillon, Jessica A; Pourzia, Alexandra L; Schad, Sara; Johnson, Shawn F; Carrasco, Ruben D; Lazo, Suzan; Bronson, Roderick T; Davis, Scott P; Lobera, Mercedes; Nolan, Michael A; Letai, Anthony.

Nature ; 543(7645): 428-432, 2017 03 16.

Artigo em Inglês | MEDLINE | ID: mdl-28273064

10.

Aneuploidy increases resistance to chemotherapeutics by antagonizing cell division.

Replogle, John Michael; Zhou, Wen; Amaro, Adrianna E; McFarland, James M; Villalobos-Ortiz, Mariana; Ryan, Jeremy; Letai, Anthony; Yilmaz, Omer; Sheltzer, Jason; Lippard, Stephen J; Ben-David, Uri; Amon, Angelika.

Proc Natl Acad Sci U S A ; 117(48): 30566-30576, 2020 12 01.

Artigo em Inglês | MEDLINE | ID: mdl-33203674

11.

Genomic evolution and chemoresistance in germ-cell tumours.

Taylor-Weiner, Amaro; Zack, Travis; O'Donnell, Elizabeth; Guerriero, Jennifer L; Bernard, Brandon; Reddy, Anita; Han, G Celine; AlDubayan, Saud; Amin-Mansour, Ali; Schumacher, Steven E; Litchfield, Kevin; Turnbull, Clare; Gabriel, Stacey; Beroukhim, Rameen; Getz, Gad; Carter, Scott L; Hirsch, Michelle S; Letai, Anthony; Sweeney, Christopher; Van Allen, Eliezer M.

Nature ; 540(7631): 114-118, 2016 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-27905446

12.

Comparing syngeneic and autochthonous models of breast cancer to identify tumor immune components that correlate with response to immunotherapy in breast cancer.

Lal, Jessica Castrillon; Townsend, Madeline G; Mehta, Anita K; Oliwa, Madisson; Miller, Eric; Sotayo, Alaba; Cheney, Emily; Mittendorf, Elizabeth A; Letai, Anthony; Guerriero, Jennifer L.

Breast Cancer Res ; 23(1): 83, 2021 08 05.

Artigo em Inglês | MEDLINE | ID: mdl-34353349

13.

Targeted inhibition of PI3Kα/Î´ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL.

Bojarczuk, Kamil; Wienand, Kirsty; Ryan, Jeremy A; Chen, Linfeng; Villalobos-Ortiz, Mariana; Mandato, Elisa; Stachura, Joanna; Letai, Anthony; Lawton, Lee N; Chapuy, Bjoern; Shipp, Margaret A.

Blood ; 133(1): 70-80, 2019 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-30322870

14.

Venetoclax combined with decitabine or azacitidine in treatment-naive, elderly patients with acute myeloid leukemia.

DiNardo, Courtney D; Pratz, Keith; Pullarkat, Vinod; Jonas, Brian A; Arellano, Martha; Becker, Pamela S; Frankfurt, Olga; Konopleva, Marina; Wei, Andrew H; Kantarjian, Hagop M; Xu, Tu; Hong, Wan-Jen; Chyla, Brenda; Potluri, Jalaja; Pollyea, Daniel A; Letai, Anthony.

Blood ; 133(1): 7-17, 2019 01 03.

Artigo em Inglês | MEDLINE | ID: mdl-30361262

15.

Biomarker-driven strategy for MCL1 inhibition in T-cell lymphomas.

Koch, Raphael; Christie, Amanda L; Crombie, Jennifer L; Palmer, Adam C; Plana, Deborah; Shigemori, Kay; Morrow, Sara N; Van Scoyk, Alexandria; Wu, Wenchao; Brem, Elizabeth A; Secrist, J Paul; Drew, Lisa; Schuller, Alwin G; Cidado, Justin; Letai, Anthony; Weinstock, David M.

Blood ; 133(6): 566-575, 2019 02 07.

Artigo em Inglês | MEDLINE | ID: mdl-30498064

16.

Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.

Sperling, Adam S; Burgess, Michael; Keshishian, Hasmik; Gasser, Jessica A; Bhatt, Shruti; Jan, Max; Slabicki, Mikolaj; Sellar, Rob S; Fink, Emma C; Miller, Peter G; Liddicoat, Brian J; Sievers, Quinlan L; Sharma, Rohan; Adams, Dylan N; Olesinski, Elyse A; Fulciniti, Mariateresa; Udeshi, Namrata D; Kuhn, Eric; Letai, Anthony; Munshi, Nikhil C; Carr, Steven A; Ebert, Benjamin L.

Blood ; 134(2): 160-170, 2019 07 11.

Artigo em Inglês | MEDLINE | ID: mdl-31043423

17.

Venetoclax with azacitidine or decitabine in patients with newly diagnosed acute myeloid leukemia: Long term follow-up from a phase 1b study.

Pollyea, Daniel A; Pratz, Keith; Letai, Anthony; Jonas, Brian A; Wei, Andrew H; Pullarkat, Vinod; Konopleva, Marina; Thirman, Michael J; Arellano, Martha; Becker, Pamela S; Chyla, Brenda; Hong, Wan-Jen; Jiang, Qi; Potluri, Jalaja; DiNardo, Courtney D.

Am J Hematol ; 96(2): 208-217, 2021 02 01.

Artigo em Inglês | MEDLINE | ID: mdl-33119898

18.

BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response.

Sarosiek, Kristopher A; Chi, Xiaoke; Bachman, John A; Sims, Joshua J; Montero, Joan; Patel, Luv; Flanagan, Annabelle; Andrews, David W; Sorger, Peter; Letai, Anthony.

Mol Cell ; 51(6): 751-65, 2013 Sep 26.

Artigo em Inglês | MEDLINE | ID: mdl-24074954

19.

Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.

Rezaei Araghi, Raheleh; Bird, Gregory H; Ryan, Jeremy A; Jenson, Justin M; Godes, Marina; Pritz, Jonathan R; Grant, Robert A; Letai, Anthony; Walensky, Loren D; Keating, Amy E.

Proc Natl Acad Sci U S A ; 115(5): E886-E895, 2018 01 30.

Artigo em Inglês | MEDLINE | ID: mdl-29339518

20.

Navitoclax enhances the effectiveness of EGFR-targeted antibody-drug conjugates in PDX models of EGFR-expressing triple-negative breast cancer.

Zoeller, Jason J; Vagodny, Aleksandr; Daniels, Veerle W; Taneja, Krishan; Tan, Benjamin Y; DeRose, Yoko S; Fujita, Maihi; Welm, Alana L; Letai, Anthony; Leverson, Joel D; Blot, Vincent; Bronson, Roderick T; Dillon, Deborah A; Brugge, Joan S.

Breast Cancer Res ; 22(1): 132, 2020 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-33256808

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