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1.
BMC Med Res Methodol ; 23(1): 138, 2023 06 13.
Artigo em Inglês | MEDLINE | ID: mdl-37312061

RESUMO

BACKGROUND: The Behavioral Risk Factor Surveillance System (BRFSS) is an annual survey designed to identify trends in the public's health. In its 2019 field survey, the U.S. state of GA tested a new 3 - item module to measure the numbers of bereaved, resident adults aged 18 years and older. Participants were eligible if they answered 'Yes' to the item 'Have you experienced the death of a family member or close friend in the years 2018 or 2019?'. This analysis explores two research questions. Can estimates for bereavement prevalence be derived without large sampling errors, low precision, and small subsamples? Can multiple imputation techniques be applied to overcome non-response and missing data to support multivariate modeling? METHODS: BRFSS is a non-institutionalized sample of adults aged 18 years and older living in the U.S. state of Georgia. Analyses in this study were conducted under two scenarios. Scenario 1 applies the complex sample weights created by the Centers for Disease Control and imputes values for missing responses. Scenario 2 treats the data as a panel - no weighting combined with removal of persons with missing data. Scenario 1 reflects the use of BRFSS data for public health and policy, while Scenario 2 reflects data as it is commonly used in social science research studies. RESULTS: The bereavement screening item has a response rate (RR) of 69.1% (5206 of 7534 persons). Demographic subgroups and categories of health have RR of 55% or more. Under Scenario 1, the estimated prevalence of bereavement is 45.38%, meaning that 3,739,120 adults reported bereaved in 2018 or 2019. The estimated prevalence is 46.02% with Scenario 2 which removes persons with any missing data (4,289 persons). Scenario 2 overestimates the bereavement prevalence by 1.39%. An illustrative logistic model is presented to show the performance of exposure to bereavement under the two data scenarios. CONCLUSIONS: Recent bereavement can be ascertained in a surveillance survey accounting for biases in response. Estimating bereavement prevalence is needed for measuring population health. This survey is limited to one US state in a single year and excludes persons aged 17 years and younger.


Assuntos
Luto , Adulto , Humanos , Sistema de Vigilância de Fator de Risco Comportamental , Georgia/epidemiologia , Prevalência , Família
2.
Health Res Policy Syst ; 21(1): 128, 2023 Dec 04.
Artigo em Inglês | MEDLINE | ID: mdl-38049859

RESUMO

BACKGROUND: The Chinese central government launched the third phase of health system reforms in 2009. After a decade since the initiation of the reform, the health system has witnessed noteworthy gains. However, there is no concurrent improvement in public satisfaction with the health system. This study analysed various factors that influence public satisfaction with the system and examined whether perceived quality of care affects public satisfaction. METHODS: A longitudinal nationally representative survey was used for this study. We used five waves of China Family Panel Studies (CFPS) survey data. The final sample consisted of 145 843 observations. A two-way fixed-effects ordered logistic model was used for the analysis. RESULTS: The results indicate that perceived good quality of care was positively associated with public satisfaction in health system regardless of rural-urban residence. Older adults and individuals with more than 3 years of college education were less likely to be satisfied with the system in rural areas. Personal income and the density of medical professionals in the geographic area tend to improve public satisfaction in rural areas. Having medical insurance coverage and fair or good self-rated health improved the probability of reporting public satisfaction in urban areas. Married people and individuals who lived in the West region were less likely to be satisfied with the health system in urban areas. CONCLUSIONS: Knowledge and skills of healthcare providers or physical quality of facilities are not sufficient in improving public satisfaction in the health system. Policymakers need to identify options to influence the important factors that affect public perception of the system. This analysis identified several policy-amenable factors to improve public perception of the health system in rural and urban China.


Assuntos
Programas Governamentais , Reforma dos Serviços de Saúde , Humanos , Idoso , Inquéritos e Questionários , Satisfação Pessoal , China , População Rural
3.
Physiol Mol Biol Plants ; 29(2): 239-251, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36875724

RESUMO

Codon usage bias (CUB) reveals the characteristics of species and can be utilized to understand their evolutionary relationship, increase the target genes' expression in the heterologous receptor plants, and further provide theoretic assistance for correlative study on molecular biology and genetic breeding. The chief aim of this work was to analyze the CUB in chloroplast (cp.) genes in nine Elaeagnus species to provide references for subsequent studies. The codons of Elaeagnus cp. genes preferred to end with A/T bases rather than with G/C bases. Most of the cp. genes were prone to mutation, while the rps7 genes were identical in sequences. Natural selection was inferred to have a powerful impact on the CUB in Elaeagnus cp. genomes, and their CUB was extremely strong. In addition, the optimal codons were identified in the nine cp. genomes based on the relative synonymous codon usage (RSCU) values, and the optimal codon numbers were between 15 and 19. The clustering analyses based on RSCU were contrasted with the maximum likelihood (ML)-based phylogenetic tree derived from coding sequences, suggesting that the t-distributed Stochastic Neighbor Embedding clustering method was more appropriate for evolutionary relationship analysis than the complete linkage method. Moreover, the ML-based phylogenetic tree based on the conservative matK genes and the whole cp. genomes had visible differences, indicating that the sequences of specific cp. genes were profoundly affected by their surroundings. Following the clustering analysis, Arabidopsis thaliana was considered the optimal heterologous expression receptor plant for the Elaeagnus cp. genes. Supplementary Information: The online version contains supplementary material available at 10.1007/s12298-023-01289-6.

4.
BMC Health Serv Res ; 22(1): 52, 2022 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-35012543

RESUMO

BACKGROUND: People with lifestyle behaviors, such as current smoking, regular drinking, and physical inactivity, may experience a lack of or delayed health care, leading to severe sickness and higher health care expenditures in the future. Hence, the current study aims to ascertain the effects of current smoking, regular drinking, and physical inactivity on health care-seeking behavior among adults who report physical discomfort in China. METHODS: The data used in this study were obtained from the China Family Panel Studies (CFPS). The final sample consisted of 44,362 individuals who participated in all five waves of data collection. Logistic regression models were used for the analysis. RESULTS: The results of fixed effects logistic regression showed that among those who reported physical discomfort, adults who currently smoked cigarettes were 0.65 times less likely to seek health care than those who formerly smoked. Compared to nondrinkers, adults who regularly drank alcohol had a decreased likelihood of seeking health care. Adults who never engaged in physical exercise had 24% lower odds of seeking health care than those who engaged in physical exercise. CONCLUSIONS: Current smoking, regular drinking, and physical inactivity decreased the probability of seeking health care among adults who reported physical discomfort. Therefore, screening and brief advice programs should be delivered by primary-level care and should pay more attention to individuals who engage in lifestyle behaviors such as current smoking, regular drinking, and physical inactivity, thus avoiding missed opportunities to treat chronic conditions and detect new diseases early.


Assuntos
Comportamento Sedentário , Fumar , Adulto , Consumo de Bebidas Alcoólicas , China , Exercício Físico , Comportamentos Relacionados com a Saúde , Humanos , Aceitação pelo Paciente de Cuidados de Saúde
5.
BMC Public Health ; 21(1): 2268, 2021 12 11.
Artigo em Inglês | MEDLINE | ID: mdl-34895186

RESUMO

BACKGROUND: Preventive risk factors such as smoking, drinking, and unhealthy weight have contributed to the accelerated rise in noncommunicable chronic diseases, which are dominant drivers of health care utilization and spending in China. However, few studies have been conducted using a large longitudinal dataset to explore the impact of such preventive risk factors on health care utilization. Therefore, this study aimed to ascertain the effects of smoking, regular drinking, and unhealthy weight on health care utilization in China. METHODS: This research was a longitudinal study using data from five waves of the China Family Panel Studies (CFPS) conducted between 2010 and 2018, and the final sample consisted of 63,260 observations (12,652 participants) across all five waves of data collection. Health care utilization was measured from two perspectives: outpatient utilization and inpatient utilization. Smoking status was categorized as never smoker, former smoker, or current smoker. Unhealthy weight was classified based on the participants' body mass index. A fixed effects logistic regression model was used for the analysis. RESULTS: The results of fixed effects logistic regression showed that current and former smokers were approximately 1.9 times and 2.0 times more likely to use outpatient care than those who never smoked, respectively (odds ratio (OR) = 1.88, p < 0.05; OR = 2.03, p < 0.05). Obese people were approximately 1.3 times more likely to use outpatient care than healthy weight people (OR = 1.26, p < 0.05). Moreover, the results show that compared to those who never smoked, for current and former smokers, the odds of being hospitalized increased by 42.2 and 198.2%, respectively (OR = 1.42; p < 0.1, OR = 2.98; p < 0.05). Compared to healthy weight people, overweight and obese people were also more likely to be hospitalized (OR = 1.11; p < 0.1, OR = 1.18; p < 0.1, respectively). CONCLUSION: Among Chinese adults, current and former smokers were more likely to use outpatient and inpatient care than those who had never smoked. Moreover, compared to healthy weight people, obese people were more likely to use outpatient and inpatient care, and overweight people were more likely to use inpatient care. These results may have important implications that support the government in making health care resource allocation decisions.


Assuntos
Consumo de Bebidas Alcoólicas , Obesidade , Aceitação pelo Paciente de Cuidados de Saúde , Fumar , Adulto , Consumo de Bebidas Alcoólicas/epidemiologia , China/epidemiologia , Humanos , Estudos Longitudinais , Obesidade/epidemiologia , Aceitação pelo Paciente de Cuidados de Saúde/estatística & dados numéricos , Fumar/epidemiologia
6.
BMC Health Serv Res ; 21(1): 895, 2021 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-34461884

RESUMO

BACKGROUND: With economic development, aging of the population, improved insurance coverage, and the absence of a formal referral system, bypassing primary healthcare facilities appear to have become more common. Chinese patients tend to visit the secondary or tertiary healthcare facilities directly leading to overcrowding at the higher-level facilities. This study attempts to analyze the factors associated with bypassing primary care facilities among patients of age 45 years or older in China. METHODS: Random effects logistic models were used to examine bypassing of primary health facilities among rural-urban patients. Data from 2011 to 2015 waves of the China Health and Retirement Longitudinal Study were used. RESULTS: Two in five older patients in China bypass primary health centers (PHC) to access care from higher-tier facilities. Urban patients were nearly twice as likely as rural patients to bypass PHC. Regardless of rural-urban residence, our analysis found that a longer travel time to primary facilities compared to higher-tier facilities increases the likelihood of bypassing. Patients with higher educational attainment were more likely to bypass PHCs. In rural areas, patients who reported their health as poor or those who experienced a recent hospitalization had a higher probability of bypassing PHC. In urban areas, older adults (age 65 years or older) were more likely to bypass PHC than the younger group. Patients with chronic conditions like diabetes also had a higher probability of bypassing. CONCLUSIONS: The findings indicate the importance of strengthening the PHCs in China to improve the efficiency and effectiveness of the health system. Significantly lower out-of-pocket costs at the PHC compared to costs at the higher tiers had little or no impact on increasing the likelihood of utilizing the PHCs. Improving service quality, providing comprehensive person-centered care, focusing on family health care needs, and providing critical preventive services will help increase utilization of PHCs as well as the effectiveness and efficiency of the health system.


Assuntos
Aceitação pelo Paciente de Cuidados de Saúde , Atenção Primária à Saúde , Idoso , Instituições de Assistência Ambulatorial , China/epidemiologia , Humanos , Estudos Longitudinais , Pessoa de Meia-Idade , População Rural
7.
Sensors (Basel) ; 21(2)2021 Jan 07.
Artigo em Inglês | MEDLINE | ID: mdl-33430365

RESUMO

After each robot end tool replacement, tool center point (TCP) calibration must be performed to achieve precise control of the end tool. This process is also essential for robot-assisted puncture surgery. The purpose of this article is to solve the problems of poor accuracy stability and strong operational dependence in traditional TCP calibration methods and to propose a TCP calibration method that is more suitable for a physician. This paper designs a special binocular vision system and proposes a vision-based TCP calibration algorithm that simultaneously identifies tool center point position (TCPP) and tool center point frame (TCPF). An accuracy test experiment proves that the designed special binocular system has a positioning accuracy of ±0.05 mm. Experimental research shows that the magnitude of the robot configuration set is a key factor affecting the accuracy of TCPP. Accuracy of TCPF is not sensitive to the robot configuration set. Comparison experiments show that the proposed TCP calibration method reduces the time consumption by 82%, improves the accuracy of TCPP by 65% and improves the accuracy of TCPF by 52% compared to the traditional method. Therefore, the method proposed in this article has higher accuracy, better stability, less time consumption and less dependence on the operations than traditional methods, which has a positive effect on the clinical application of high-precision robot-assisted puncture surgery.


Assuntos
Médicos , Procedimentos Cirúrgicos Robóticos , Robótica , Calibragem , Humanos , Punções
8.
Sensors (Basel) ; 20(20)2020 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-33076576

RESUMO

Tripping is a common problem that everyone faces when walking. This paper mainly focuses on a lower limb exoskeleton that can help those weak in joints to avoid tripping when negotiating stairs or stepping over obstacles. This method does not need a camera or map reconstruction to recognize the obstacles and plan paths. The exoskeleton applies an impedance controller to follow and control the pilot's movements. A virtual potential field is proposed to help the robot regulate the pilot's motion and avoid kicking the obstacles appearing in front of the pilot's foot during walking. Simulation and experiments show that this method works effectively and could help the elderly and those affected by joint weakness avoid tripping when walking.


Assuntos
Exoesqueleto Energizado , Caminhada , Idoso , Fenômenos Biomecânicos , , Humanos , Extremidade Inferior , Movimento
9.
Subst Use Misuse ; 53(12): 1974-1983, 2018 10 15.
Artigo em Inglês | MEDLINE | ID: mdl-29578826

RESUMO

OBJECTIVES: To estimate how tobacco consumption affects household expenditure on other goods and services in rural China and to assess the tobacco consumption affects self-rated health among rural household members in China. METHODS: A Seemingly Unrelated Regression was used to assess the impact of tobacco consumption on rural household expenditure. To detect tobacco consumption causing heterogeneity in self-rated health among adults in rural China, this study employed a random effects generalized ordered probit model. 2010-2014 China Family Panel Studies was used for the analysis. The data set included 3,611 households and 10,610 adults in each wave. RESULTS: Tobacco consumption households assign significantly lower budget shares to food, health care, dress, and education in rural China. Moreover, self-rated health factor has a significantly positive coefficient with respect to non-smokers and ex-smokers, that is, when the individuals is a non-smoker or ex-smoker, he/ she will be more likely to report his/her health status as positive. CONCLUSIONS: The first analysis showed that tobacco consumption crowds out expenditures on food, dress, health care, and education for rural households in China, and the second analysis indicated that non-smokers and ex-smokers are more likely to report their health status as better compared with last year. The results of the present study revealed that Chinese policymakers might consider controlling tobacco consumption since tobacco control can improve not only rural household welfare but also rural household members' health status. Therefore, the tobacco tax policy and brief clinical interventions by the doctor should be implemented in rural China.


Assuntos
Educação/economia , Alimentos/economia , Gastos em Saúde/estatística & dados numéricos , Nível de Saúde , Fumar/epidemiologia , Produtos do Tabaco/economia , China/epidemiologia , Emprego , Características da Família , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Política Pública , População Rural , Fumar/economia , Impostos
10.
Nanotechnology ; 28(21): 215401, 2017 May 26.
Artigo em Inglês | MEDLINE | ID: mdl-28379157

RESUMO

T-Nb2O5 quantum dots were electrodeposited on Ti nanorod arrays to prepare Ti@T-Nb2O5 core-shell array electrodes. The particle size of T-Nb2O5 could be manipulated by adjusting the depositing current density, and quantum dots several nanometers in size could be obtained at a deposition current of 6 mA cm-2. Benefiting from the ultra-small particle size of T-Nb2O5 and the array structure, Ti@T-Nb2O5 nanorod arrays exhibited good rate capability and durability when used as self-supported Li ion battery anodes. The arrays possessed capacities of 350 and 70 mAh g-1 at rate currents of 0.06 and 30 A g-1, respectively. Furthermore, the electrodes maintained 500 cycles without obvious decay at a high rate current of 30 A g-1.

11.
Sensors (Basel) ; 17(7)2017 Jun 27.
Artigo em Inglês | MEDLINE | ID: mdl-28654003

RESUMO

The tiger beetle can maintain its stability by controlling the interaction force between its legs and an unstructured terrain while it runs. The biomimetic hexapod robot mimics a tiger beetle, and a comprehensive force sensing system combined with certain algorithms can provide force information that can help the robot understand the unstructured terrain that it interacts with. This study introduces a complicated leg force sensing system for a hexapod robot that is the same for all six legs. First, the layout and configuration of sensing system are designed according to the structure and sizes of legs. Second, the joint toque sensors, 3-DOF foot-end force sensor and force information processing module are designed, and the force sensor performance parameters are tested by simulations and experiments. Moreover, a force sensing system is implemented within the robot control architecture. Finally, the experimental evaluation of the leg force sensor system on the hexapod robot is discussed and the performance of the leg force sensor system is verified.

12.
Sensors (Basel) ; 15(11): 28005-30, 2015 Nov 05.
Artigo em Inglês | MEDLINE | ID: mdl-26556357

RESUMO

Wireless Body Area Networks (WBANs) can provide real-time and reliable health monitoring, attributing to the human-centered and sensor interoperability properties. WBANs have become a key component of the ubiquitous eHealth (electronic health) revolution that prospers on the basis of information and communication technologies. The prime consideration in WBAN is how to maximize the network lifetime with battery-powered sensor nodes in energy constraint. Novel solutions in Medium Access Control (MAC) protocols are imperative to satisfy the particular BAN scenario and the need of excellent energy efficiency in healthcare applications. In this paper, we propose a hybrid Lifetime Extended Directional Approach (LEDA) MAC protocol based on IEEE 802.15.6 to reduce energy consumption and prolong network lifetime. The LEDA MAC protocol takes full advantages of directional superiority in energy saving that employs multi-beam directional mode in Carrier Sense Multiple Access/Collision Avoidance (CSMA/CA) and single-beam directional mode in Time Division Multiple Access (TDMA) for alternative in data reservation and transmission according to the traffic varieties. Moreover, the impacts of some inherent problems of directional antennas such as deafness and hidden terminal problem can be decreased owing to that all nodes generate individual beam according to user priorities designated. Furthermore, LEDA MAC employs a Dynamic Polled Allocation Period (DPAP) for burst data transmissions to increase the network reliability and adaptability. Extensive analysis and simulation results show that the proposed LEDA MAC protocol achieves extended network lifetime with improved performance compared with IEEE 802.15.6.


Assuntos
Redes de Comunicação de Computadores/instrumentação , Tecnologia de Sensoriamento Remoto/instrumentação , Tecnologia sem Fio/instrumentação , Desenho de Equipamento , Humanos
13.
Psychol Res Behav Manag ; 17: 201-216, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38264346

RESUMO

Objective: This study was conducted to identify the factors (especially parental involvement, academic self-efficacy, and depression) associated with academic performance among Chinese K-12 students during the COVID-19 pandemic. Methods: This cross-sectional study used data from the 2020 China Family Panel Studies (CFPS). The CFPS was conducted from July to December 2020 during the COVID-19 pandemic. A multistage probability sample proportional to size was used for the survey. The final sample consisted of 1747 K-12 students. This study used the 14-item Chinese Parental Involvement and Support Scale, the Responsibility Scale, and the 8-item Center for Epidemiologic Studies Depression Scale to measure parental involvement, academic self-efficacy, and depression, respectively. An ordered probit regression and structural equation models were employed to analyze the factors associated with academic performance. A multiple imputation technique was applied to compute missing values in selected variables. Results: We found that parental involvement and academic self-efficacy were positively associated with good academic performance. In contrast, depression was negatively associated with good academic performance. Moreover, academic stress, male, rural residency, middle school, family size, high income, online gaming daily, reading, and intelligence quotient were statistically significant predictors on academic performance. Conclusion: The empirical findings suggested that parental involvement and academic self-efficacy were positively and significantly associated with good academic performance. However, depression was negatively and significantly associated with good academic performance. These results showed that policymakers and practitioners can help improve academic success and address educational inequalities among K-12 students by implementing a series of reforms.

14.
Huan Jing Ke Xue ; 45(3): 1821-1829, 2024 Mar 08.
Artigo em Zh | MEDLINE | ID: mdl-38471893

RESUMO

To clarify the impact of the structure and function of soil microbial communities in the stage of abandoned farmland, three different stages of land abandoned in desert oasis areas were selected as the research objects. We used metagenomic sequencing technology to research soil microbial community structure and functional diversity characteristics of different stages of abandoned farmland. The results showed that there were significant differences in the relative abundance of the dominant phyla Actinobacteria, Proteobacteria, and Gemmatimonadetes in the soil of the three stages of returning farmland. Compared with that in the early stage of abandoned farmland, the later stage of abandoned farmland restoration increased the gene proportion involved in Quorum sensing, porphyrin and chlorophyll metabolism, pantothenate and CoA biosynthesis, and styrene degradation, and there was a significant difference in relative abundance (P<0.05), which indicated that different stages of abandoned farmland had changed the functional potential of the nutrient cycle and energy metabolism in soil microbial communities. The RDA results showed that EC, AK, and TN had a significant impact on the functional composition of soil microbes, and soil EC had the greatest impact on microbial functional composition. The results showed that different stages of abandoned farmland had a significant impact on the soil microbial community structure and functional composition. In the ecological restoration of abandoned farmland in Minqin Oasis, the sensitivity of microbial community structure and functional composition to soil restoration at different stages should be considered using comprehensive relevant indicators.


Assuntos
Microbiota , Solo , Solo/química , Fazendas , Microbiologia do Solo , Bactérias
15.
J Robot Surg ; 18(1): 219, 2024 May 21.
Artigo em Inglês | MEDLINE | ID: mdl-38771389

RESUMO

An experimental validation of a robotic system for radioactive iodine-125 seed implantation (RISI) in tumor treatment was conducted using customized phantom models and animal models simulating liver and lung lesions. The robotic system, consisting of planning, navigation, and implantation modules, was employed to implant dummy radioactive seeds into the models. Fiducial markers were used for target localization. In phantom experiments across 40 cases, the mean errors between planned and actual seed positions were 0.98 ± 1.05 mm, 1.14 ± 0.62 mm, and 0.90 ± 1.05 mm in the x, y, and z directions, respectively. The x, y, and z directions correspond to the left-right, anterior-posterior, and superior-inferior anatomical planes. Silicone phantoms exhibiting significantly smaller x-axis errors compared to liver and lung phantoms (p < 0.05). Template assistance significantly reduced errors in all axes (p < 0.05). No significant dosimetric deviations were observed in parameters such as D90, V100, and V150 between plans and post-implant doses (p > 0.05). In animal experiments across 23 liver and lung cases, the mean implantation errors were 1.28 ± 0.77 mm, 1.66 ± 0.69 mm, and 1.86 ± 0.93 mm in the x, y, and z directions, slightly higher than in phantoms (p < 0.05), with no significant differences between liver and lung models. The dosimetric results closely matched planned values, confirming the accuracy of the robotic system for RISI, offering new possibilities in clinical tumor treatment.


Assuntos
Radioisótopos do Iodo , Neoplasias Pulmonares , Imagens de Fantasmas , Procedimentos Cirúrgicos Robóticos , Procedimentos Cirúrgicos Robóticos/métodos , Procedimentos Cirúrgicos Robóticos/instrumentação , Radioisótopos do Iodo/uso terapêutico , Animais , Neoplasias Pulmonares/radioterapia , Braquiterapia/métodos , Braquiterapia/instrumentação , Neoplasias Hepáticas/radioterapia , Humanos , Marcadores Fiduciais
16.
J Mater Chem B ; 12(29): 7135-7142, 2024 Jul 24.
Artigo em Inglês | MEDLINE | ID: mdl-38952205

RESUMO

Fluorescence-image guided surgery (FGS) can intraoperatively provide real-time visualization of a tumor incisal edge and high-resolution identification of tumor foci to improve treatment outcomes. In this contribution, we report a fluorescent probe NB-TAM based on intramolecularly folded photoinduced electron transfer (PET), which displayed a prominent turn-on response in the near-infrared (NIR) window upon specific interaction with the estrogen receptor (ER). Significantly, NB-TAM could delineate a clear tumor incisal edge (tumor-to-normal tissue ratio > 5) in a 70-min time window, and was successfully used to guide the facile and precise resection of ER+ breast tumors in mice. To our surprise, NB-TAM was found to be capable of identifying very tiny lung metastatic ER+ breast tumor foci (0.4 × 0.3 mm), and this ultrahigh resolution was essential to effectively promote tumor resection precision and early diagnosis of tiny tumors. These results clearly elucidate the promising application of NB-TAM as a diagnostic agent for intraoperative fluorescence imaging of ER+ breast cancer.


Assuntos
Neoplasias da Mama , Corantes Fluorescentes , Imagem Óptica , Receptores de Estrogênio , Animais , Corantes Fluorescentes/química , Feminino , Neoplasias da Mama/patologia , Neoplasias da Mama/diagnóstico por imagem , Humanos , Camundongos , Receptores de Estrogênio/metabolismo , Receptores de Estrogênio/análise , Camundongos Endogâmicos BALB C , Camundongos Nus
17.
Patient Prefer Adherence ; 17: 3067-3080, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38027085

RESUMO

Purpose: Medical care delay or avoidance increases morbidity and mortality risk and is costly for the national healthcare system. The objective of this study was to identify factors associated with medical care delay or avoidance among Chinese adults during the COVID-19 pandemic. Materials and Methods: A cross-sectional analysis was conducted using data from the 2020 China Family Panel Study (CFPS). The CFPS was conducted from July to December 2020 during the COVID-19 pandemic. The final sample included 4369 adults. A logistic regression model was employed to identify the factors associated with medical care delay or avoidance. Results: The empirical results indicate that regardless of rural-urban residence, older adults and adults with chronic conditions were less likely to delay or avoid medical care during the pandemic. However, individuals who had completed more than three years of college showed a higher likelihood of delaying or avoiding medical care. In urban areas, larger family sizes, greater general trust in physicians, and higher provider structural quality were associated with a decreased probability of delaying or avoiding medical care during the pandemic. In contrast, employed adults were more likely to delay or avoid medical care. In rural areas, current smokers were more likely to delay or avoid medical care during the pandemic. Conclusion: This study has identified several factors affecting medical care delay or avoidance, some of which are amenable to policy changes. Policymakers can help improve the utilization of health facilities and patient health outcomes by implementing a series of reforms.

18.
Soc Sci Med ; 320: 115704, 2023 03.
Artigo em Inglês | MEDLINE | ID: mdl-36696796

RESUMO

RATIONALE: Public trust in physicians had declined in China for decades before the COVID-19 pandemic. During the COVID-19 pandemic, frontline physicians have experienced high work volume despite a high risk of COVID-19 infection. The willingness of physicians to treat COVID patients with a high risk of exposure to the infection may have improved public trust in physicians. OBJECTIVE: This study analyzes how public trust in physicians has changed since the pandemic started using a nationally representative survey. METHODS: We used the China Family Panel Studies (CFPS), with 179,123 respondents 10 years or older who were eligible to answer the question on public trust in physicians from 2012 to 2020. Public trust has been measured by an 11-point Likert scale. A quasi pre-post study design using a segmented regression impact model was used to evaluate the impact of the COVID-19 pandemic on public trust in physicians. RESULTS: At the start of the observation period, the average public trust score was 6.86 out of 10.00. The immediate unadjusted change of mean score for public trust during COVID-19 was significantly higher (Coef. = 0.361; 95% CI = 0.359, 0.364). Moreover, a significant increase in the unadjusted trend during the COVID-19 pandemic was observed in the mean score for public trust (Coef. = 0.005; 95% CI = 0.004, 0.006). The results were similar to the estimates obtained when we adjusted for demographic characteristics and health status. CONCLUSIONS: The mean score for public trust increased during the COVID-19 pandemic. This study provides a new perspective on restoring public trust in physicians, a significant concern of the Chinese healthcare system. During the COVID-19 pandemic, social and mainstream media helped to establish the "good doctor" image, which may have improved patients' trust in physicians. Improving health literacy through effective communication and education may help increase public trust in physicians.


Assuntos
COVID-19 , Médicos , Humanos , Pandemias , Confiança , China
19.
BMC Psychol ; 11(1): 398, 2023 Nov 17.
Artigo em Inglês | MEDLINE | ID: mdl-37978396

RESUMO

BACKGROUND: Although the tobacco epidemic is one of the greatest public health threats, the smoking cessation rate among Chinese adults is considerably lower. Personality information may indicate which treatments or interventions are more likely to be effective. China is the largest producer and consumer of tobacco worldwide. However, little is known about the association between smoking cessation and personality traits in China. AIM: This study aimed to examine the association between successful smoking cessation and personality traits among Chinese adults. METHODS: This cross-sectional study used data from the 2018 China Family Panel Studies. Probit regression models were employed to analyze the association between successful smoking cessation and personality traits stratified by sex. RESULTS: Lower scores for neuroticism (Coef.=-0.055, p < 0.1), lower scores for extraversion (Coef.=-0.077, p < 0.05), and higher scores for openness to experience (Coef.=0.045, p < 0.1) predicted being a successful male quitter after adjusting for demographics. Moreover, lower scores for conscientiousness (Coef.=-0.150, p < 0.1) predicted being a successful female quitter after adjusting for demographics. CONCLUSION: The empirical findings suggested that among Chinese men, lower levels of neuroticism, lower levels of extraversion, and higher levels of openness to experience were associated with a higher likelihood of smoking cessation. Moreover, lower levels of conscientiousness were associated with successful smoking cessation among Chinese women. These results showed that personality information should be included in smoking cessation interventions.


Assuntos
Abandono do Hábito de Fumar , Humanos , Masculino , Adulto , Feminino , Estudos Transversais , População do Leste Asiático , Personalidade , Neuroticismo , Inventário de Personalidade
20.
Artigo em Inglês | MEDLINE | ID: mdl-37239563

RESUMO

BACKGROUND: Binge drinking is a pattern of alcohol abuse. Its prevalence and associated risk factors are not well documented. Heavy drinking, on the other hand, has a well-documented association with bereavement. This report uses a cross-sectional, population-based survey to estimate prevalence of bingeing and its association with new bereavement. Bingeing is defined as 4 or more drinks (women) or 5 or more drinks (men) in a 2-4-h setting. For the first time in 2019, the Georgia Behavioral Risk Factor Surveillance Survey (BRFSS) included a bereavement item: 'Have you experienced the death of a family member or close friend in the years 2018 or 2019?' METHODS: Georgia BRFSS is a complex sampling survey administered annually. It is designed to represent the 8.1 million people aged 18 years and older in the U.S. state of Georgia. Alcohol consumption patterns are routinely measured in the common core. In 2019, the state added a new item probing for bereavement in the prior 24 months predating the COVID-19 pandemic. Imputation and weighting techniques were applied to yield the population prevalence rates of new bereavement, bingeing, and their co-occurrence with other high-risk health behaviors and outcomes. Multivariate models, adjusted for age, gender, and race, were used to estimate the risk for other unhealthy behaviors posed by the co-occurrence of bereavement and bingeing. RESULTS: In Georgia, bereavement (45.8%), and alcohol consumption (48.8%) are common. Bereavement and alcohol use co-occurred among 1,796,817 people (45% of all drinkers) with a subset of 608,282 persons reporting bereavement combined with bingeing. The most common types of bereavement were death of a friend/neighbor (30.7%) or three plus deaths (31.8%). CONCLUSIONS: While bingeing is a known risk to public health, its co-occurrence with recent bereavement is a new observation. Public health surveillance systems need to monitor this co-occurrence to protect both individual and societal health. In a time of global bereavement, documenting its influence on binge drinking can support the work towards Sustainable Development Goal #3-Good health and Well-Being.


Assuntos
Luto , Consumo Excessivo de Bebidas Alcoólicas , COVID-19 , Masculino , Humanos , Feminino , Estados Unidos , Georgia/epidemiologia , Prevalência , Estudos Transversais , Consumo Excessivo de Bebidas Alcoólicas/epidemiologia , Pandemias , COVID-19/epidemiologia , Etanol , Consumo de Bebidas Alcoólicas/epidemiologia , Fatores de Risco , Sistema de Vigilância de Fator de Risco Comportamental
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