Detalhe da pesquisa
1.
Soy Protein Containing Diet Attenuates Murine Drug Exposure and Activity via Hepatic and Intestinal Cytochrome P450 Induction.
Drug Metab Dispos
; 51(8): 1005-1015, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37142426
2.
An Overview of Machine Learning and Big Data for Drug Toxicity Evaluation.
Chem Res Toxicol
; 33(1): 20-37, 2020 01 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-31625725
3.
Transcriptomic evaluation of canine suspension-shipped and pre-plated hepatocytes: comparison to liver.
Toxicol Mech Methods
; 23(7): 479-90, 2013 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-23581556
4.
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects.
J Pharmacol Toxicol Methods
; 123: 107468, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37553032
5.
A systems approach reveals species differences in hepatic stress response capacity.
Toxicol Sci
; 196(1): 112-125, 2023 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37647630
6.
Preclinical species gene expression database: Development and meta-analysis.
Front Genet
; 13: 1078050, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36733943
7.
Role of cytochrome P450c17α in dibromoacetic acid-induced testicular toxicity in rats.
Arch Toxicol
; 85(5): 513-23, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21046364
8.
Global transcriptomic profiling using small volumes of whole blood: a cost-effective method for translational genomic biomarker identification in small animals.
Int J Mol Sci
; 12(4): 2502-17, 2011.
Artigo
em Inglês
| MEDLINE | ID: mdl-21731455
9.
Comparison of TNFα to lipopolysaccharide as an inflammagen to characterize the idiosyncratic hepatotoxicity potential of drugs: Trovafloxacin as an example.
Int J Mol Sci
; 11(11): 4697-714, 2010 Nov 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21151465
10.
Managing the challenge of drug-induced liver injury: a roadmap for the development and deployment of preclinical predictive models.
Nat Rev Drug Discov
; 19(2): 131-148, 2020 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-31748707
11.
Screening Strategies and Methods for Better Off-Target Liability Prediction and Identification of Small-Molecule Pharmaceuticals.
SLAS Discov
; 24(1): 1-24, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30196745
12.
Potential mechanisms of target-independent uptake and toxicity of antibody-drug conjugates.
Pharmacol Ther
; 200: 110-125, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-31028836
13.
Novel Computational Approach to Predict Off-Target Interactions for Small Molecules.
Front Big Data
; 2: 25, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-33693348
14.
Gene expression profiles in livers from diclofenac-treated rats reveal intestinal bacteria-dependent and -independent pathways associated with liver injury.
J Pharmacol Exp Ther
; 327(3): 634-44, 2008 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-18801949
15.
Trovafloxacin-induced gene expression changes in liver-derived in vitro systems: comparison of primary human hepatocytes to HepG2 cells.
Drug Metab Dispos
; 36(2): 223-33, 2008 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-17967932
16.
Comparison of RNA-Seq and Microarray Gene Expression Platforms for the Toxicogenomic Evaluation of Liver From Short-Term Rat Toxicity Studies.
Front Genet
; 9: 636, 2018.
Artigo
em Inglês
| MEDLINE | ID: mdl-30723492
17.
Test systems in drug discovery for hazard identification and risk assessment of human drug-induced liver injury.
Expert Opin Drug Metab Toxicol
; 13(7): 767-782, 2017 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-28604124
18.
Investigations toward enhanced understanding of hepatic idiosyncratic drug reactions.
Expert Opin Drug Metab Toxicol
; 2(6): 835-46, 2006 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-17125404
19.
Biomarker evaluation of skeletal muscle toxicity following clofibrate administration in rats.
Exp Toxicol Pathol
; 68(5): 289-99, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-27020044
20.
Anti-repulsive Guidance Molecule C (RGMc) Antibodies Increases Serum Iron in Rats and Cynomolgus Monkeys by Hepcidin Downregulation.
AAPS J
; 17(4): 930-8, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25896304